Navigation Links
Nature study shows how molecules escape from the nucleus
Date:9/16/2010

and the observation that 10 percent of messenger RNA molecules sit for seconds at nuclear pores without gaining entry, suggest that messenger RNA could be screened for quality at this point.

"Researchers have speculated that messenger RNA molecules that are defective in some way, perhaps because the genes they're derived from are mutated, may be inspected and destroyed before getting into the cytoplasm or a short time later, and the question has been, 'Where might that surveillance be happening?'," said Dr. Singer. "So we're wondering if those messenger RNA molecules that couldn't get through the nuclear pores were subjected to a quality control mechanism that didn't give them a clean bill of health for entry."

In previous research, Dr. Singer studied myotonic dystrophy, a severe inherited disorder marked by wasting of the muscles and caused by a mutation involving repeated DNA sequences of three nucleotides. Dr. Singer found that in the cells of people with myotonic dystrophy, messenger RNA gets stuck in the nucleus and can't enter the cytoplasm. "By understanding how messenger RNA exits the nucleus, we may be able to develop treatments for myotonic dystrophy and other disorders in which messenger RNA transport is blocked," he said.


'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Quantum computer a stage closer with silicon breakthrough, reports Nature journal
2. Study sheds light into the nature of embryonic stem cells
3. Muscular protein bond -- strongest yet found in nature
4. Nature parks can save species as climate changes
5. Sangamo BioSciences Announces Publication in Nature of the Use of Zinc Finger Nucleases to Accelerate Precision Trait Stacking in Commercial Crop Species
6. Cell Biosciences Announces Publication in Nature Medicine
7. Nature Medicine study shows Peregrines bavituximab can cure lethal virus infections
8. Nature Reviews Publishes Article About Jennerexs Multi-Mechanistic Cancer Therapeutic
9. Light-speed nanotech: Controlling the nature of graphene
10. Data Published in Nature Cell Biology Reveal Novel Function of Drug Target EpCAM in Cancer Cell Signalling
11. Research Published in Nature Medicine Shows Disruption of Chemokine Interactions Inhibits Atherosclerosis in Mice
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nature study shows how molecules escape from the nucleus
(Date:7/29/2014)... separated from its properties? On July 29, the prestigious ... the first Cheshire Cat experiment, separating a neutron from ... CA, and Vienna University of Technology. , Chesire Cat"Well! ... Alice in Wonderland, "but a grin without a cat! ... my life!" Alice,s surprise stems from her experience that ...
(Date:7/29/2014)... 29, 2014 Second generation biofuels are a ... fossil fuels. However, as natural gas is very cheap, this ... are not as valuable as they could be in comparison ... financing projects, has made it difficult for renewable energy developers ... off the ground. For these reasons, certain companies have shifted ...
(Date:7/29/2014)... 2014  Cannabis Science, Inc. (OTC: CBIS), a ... and related consulting, applauds the Editorial Board of ... position in opposition to current federal law on ... The New York Times also announces a series ... the issue called "High Time:  An Editorial Series ...
(Date:7/29/2014)... July 29, 2014 Genera ... feedstock supply innovation and supply chain advancements, has ... management systems, Energy Grange™ and Supply ASSURE™. ... and in-the-field testing aimed at consolidating and simplifying ... to landowners, farmers and feedstock end users. , ...
Breaking Biology Technology:The quantum Cheshire cat: Scientists separate a particle from its properties 2The quantum Cheshire cat: Scientists separate a particle from its properties 3The quantum Cheshire cat: Scientists separate a particle from its properties 4Renewable Waste Intelligence: Could Renewable Chemicals Be the Future for the Renewable Energy Industry? 2Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 2Cannabis Science, Inc. (CBIS) Applauds New York Times Editorial Board Stance on 'Repealing Prohibition, Again'; NYT Editorial Is Bell Weather of Change 3Genera Energy Introduces Proprietary Feedstock Management Systems 2Genera Energy Introduces Proprietary Feedstock Management Systems 3Genera Energy Introduces Proprietary Feedstock Management Systems 4
... completed phase of the new Children,s,Hospital campus, PITTSBURGH, ... opened its new 10-story, state-of-the-art John G. Rangos,Sr. Research ... new,premier pediatric campus., With more than 300,000 square ... hub of pediatric health research for the region. The ...
... October 29, Rosetta Genomics Ltd. (Nasdaq: ROSG ), ... today its,management will present at Oppenheimer 19th Annual ... Waldorf-Astoria Hotel in New York,City., About MicroRNA, ... small,RNAs that act as master regulators and have ...
... at ImClone Brings Substantial,Oncology Drug Development Expertise, ... ("Senesco" or the "Company") (NYSE Alternext US: SNT),announced ... 55 to its board,of directors. Senesco,s board of ... are independent., (Photo: http://www.newscom.com/cgi-bin/prnh/20081029/NY42202 ), ...
Cached Biology Technology:Opening Dedication of the New John G. Rangos Sr. Research Center at the New Children's Hospital of Pittsburgh of UPMC Campus in Lawrenceville 2Opening Dedication of the New John G. Rangos Sr. Research Center at the New Children's Hospital of Pittsburgh of UPMC Campus in Lawrenceville 3Rosetta Genomics to Present at Oppenheimer's 19th Annual Healthcare Conference 2Rosetta Genomics to Present at Oppenheimer's 19th Annual Healthcare Conference 3Senesco Appoints Harlan W. Waksal, M.D., to Board of Directors 2Senesco Appoints Harlan W. Waksal, M.D., to Board of Directors 3
(Date:7/28/2014)... An international team of researchers led by the University ... rice. , The genetic information will enhance scientists, and ... as well as enable the development of new rice ... environmental stressors to help solve global hunger challenges. , ... Oryza glaberrima ) and evidence for independent domestication," was ...
(Date:7/28/2014)... Reactions among minerals and organic compounds in hydrothermal environments ... they provide energy for the deep biosphere, and may ... little is known about how minerals influence organic reactions. ... have demonstrated how a common mineral acts as a ... need for toxic solvents or expensive reagents. , At ...
(Date:7/28/2014)... mechanism in part of the brain that is key to ... type 1 and type 2 diabetes. The findings are published ... National Academies of Sciences . , "We,ve discovered that ... the hypothalamus known as the ventromedial nucleus sets a ... the blood," said lead author Sabrina Diano, professor in the ...
Breaking Biology News(10 mins):Generating a genome to feed the world: UA-led team sequences African rice 2Generating a genome to feed the world: UA-led team sequences African rice 3Generating a genome to feed the world: UA-led team sequences African rice 4Mineral magic? Common mineral capable of making and breaking bonds 2Mineral magic? Common mineral capable of making and breaking bonds 3Glucose 'control switch' in the brain key to both types of diabetes 2
... are primary producers of ammonia in Houston,s atmosphere, and cars ... according to a new study by researchers at Rice University ... air quality draws minimal oversight from the Environmental Protection Agency ... it means to life in and around the metropolis. ...
... N.Y. DNA and protein sequencing have forever ... of these complex biomolecules has revolutionized drug development, ... evolution and development. But, one major molecule in ... biopolymers. Today, for the first time ...
... A tiny piece of a critical receptor that fuels the ... discovered by University at Buffalo scientists as a promising new ... on the NMDA (N-methyl-D-aspartate) receptor is being published online Oct. ... time that this site has been shown to be useful ...
Cached Biology News:Ammonia gets overdue overview 2Ammonia gets overdue overview 3Uncharted territory: Scientists sequence the first carbohydrate biopolymer 2Uncharted territory: Scientists sequence the first carbohydrate biopolymer 3New drug target for Alzheimer's, stroke is discovered by University at Buffalo scientists 2
EoProbe Eosinophil Staining Kit, 1 Kit...
... A.P. Johnstone and M.W. ... book describes step-by-step methods ... immunologically relevant molecules, the ... highly specific analytical probes ...
B.D. Hames and D.M. Glover (1996) • This issue covers T-Cell antigen receptor genes; T-Lymphocyte signal transduction; B-Cell activation antibody engineering and the complement system and other ...
Request Info...
Biology Products: