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Nature article focuses on tinnitus treatment
Date:1/12/2011

S study, the research team used a "gap detection model" to document tinnitus in rats that were exposed to loud noise for one hour while under anesthesia. Each of the noise-exposed rats used in this study exhibited a significant impairment in the ability to detect a quiet gap in a tone near their tinnitus frequency, but exhibited no impairment when the gap was placed in a higher or lower tone.

"Previous research showed that a frequency-specific impairment in gap detection is a likely sign that noise-exposed rats experience a mid-frequency tinnitus 'ringing' that fills the silent gaps," Kilgard said. "Though it isn't possible to evaluate the subjective experience of rats, this gap impairment has been taken as an indicator of tinnitus."

When the rats were exposed to VNS paired with sounds, the gap impairment was eliminated indicating that the tinnitus was gone.

Today's therapies for tinnitus have limited success and frequently must be modified over time because they become ineffective. "The VNS treatment would be an improvement over current therapies involving medications or counseling because it offers a possible permanent end to the condition and doesn't appear to cause any significant side effects," Kilgard said.


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Contact: Emily Martinez
emily.martinez@utdallas.edu
972-883-4335
University of Texas at Dallas
Source:Eurekalert

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