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Nature article focuses on tinnitus treatment
Date:1/12/2011

eloping parameters for a clinical trial in humans. Vagus nerve stimulation (VNS) is currently used in humans for treatment of epilepsy and depression. "The translation from basic science to the clinic has been quite rapid," Engineer said. "It's exciting that the National Institutes for Health has been so supportive of our efforts to move this work along faster, in hopes of providing effective treatments to tinnitus patients."

The National Institutes of Health (NIH) early in 2010 granted Kilgard and MicroTransponder $1.7 million to further investigate whether nerve stimulation offers a long-term cure for tinnitus.

The first patient could be treated in Europe by early 2011, Engineer said. The initial set of human participants will have the electrodes attached to the left vagus nerve in their neck during a short outpatient procedure. They will come to the clinic Monday through Friday for a few weeks of treatment. At each daily session, they will experience VNS paired with sounds.

MicroTransponder, a neuroscience based medical device company, was founded by UT Dallas PhD candidate Will Rosellini and sponsored by the school's Institute for Innovation and Entrepreneurship. MicroTransponder is developing a less invasive wireless medical device to stimulate the vagus nerve. The UT Dallas/MicroTransponder team also is studying how best to optimize the paired therapy for tinnitus patients.

Past research has shown that the severity of chronic pain and tinnitus is tied to the degree of plasticity in the brain's cortex. A previous study showed that repeatedly pairing sensory stimuli with electrical stimulation of a brain structure called nucleus basalis generates powerful and long-lasting changes in cortical organization. Since the vagus nerve is easier to access for clinical use, and is known to trigger the release of molecules in the brain that promote neural changes, follow-up studies were performed on the vagus nerve.

For the VN
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Contact: Emily Martinez
emily.martinez@utdallas.edu
972-883-4335
University of Texas at Dallas
Source:Eurekalert

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