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Nature Reviews Publishes Article About Jennerex's Multi-Mechanistic Cancer Therapeutic
Date:2/10/2009

ucts from this breakthrough therapeutic class can systemically target cancers in a highly selective and potent fashion using a multi-pronged mechanism of action. Jennerex products replicate in cancer cells, leading to cancer cell destruction, while normal cells are left unharmed. The Phase 1 study results were recently published in prestigious journals Lancet Oncology and Molecular Therapy.

The poxvirus strain backbone of Jennerex's cancer therapeutics have been used safely in millions of people as part of a worldwide vaccination program against smallpox. This strain naturally targets cancer cells due to common genetic defects in cancer cells. The products are activated by genetic pathways that are critical to the vast majority of human cancers, such as the EGFR-ras pathway, and they employ a novel primary mechanism-of-action that is effective even against cancers that are resistant to standard therapies such as chemotherapy and radiation. Simultaneously, a therapeutic cascade is initiated by product replication resulting in tumor vasculature shutdown and anti-tumoral immune attack. In addition, these products are "armed" with immune-stimulatory GM-CSF that destroys cancers by complementary and synergistic mechanisms.

"This extensive scientific review examines the huge strides made in the field of viral therapy over the past 15 years," said Dr. Stephen Thorne, Assistant Professor at the University of Pittsburgh Cancer Institute and Coauthor.

About Jennerex

Jennerex is a clinical-stage biopharmaceutical company focused on the development and commercialization of first-in-class, breakthrough targeted oncolytic products for cancer. The company's lead product JX-594, currently in an international Phase 2 trial for primary liver cancer and colorectal cancer, demonstrated promising Phase 1 efficacy and safety results in patients with a diverse array of common cancers. Jenner
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SOURCE Jennerex, Inc.
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