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National MS Society Reports Sweeping Advances Made in MS Research in 2012
Date:12/27/2012

rkers” to aid better diagnosis and treatment decisions;
  •     Collaboration in a cross-disease drug screening initiative aimed at discovering the potential of compounds to stop nerve degeneration and protect the brain from harm;
  •     In partnership with Merck Serono, Fast Forward provided funding for lab research to discover small molecules that can deliver therapies to areas of nervous system damage and protect against that damage in MS.
  • Other important 2012 results toward stopping MS include:

    TREATMENT PIPELINE
    FDA Approves Oral Aubagio® (Teriflunomide, Genzyme, a Sanofi company)– The once-daily pill was approved as a disease-modifying therapy for relapsing forms of MS. Aubagio is the second oral disease-modifying therapy approved for the treatment of MS, and it became available for prescription in October 2012 in the U.S. http://www.nationalmssociety.org/news/news-detail/index.aspx?nid=6864

    Two potential therapies are before FDA –

    •     Biogen Idec applied to the FDA for approval of BG-12 to treat relapsing MS. This oral therapy showed benefits against relapses and other MS activity in recent trials. The FDA review is underway.
    •     Genzyme applied for approval of alemtuzumab to treat relapsing MS, based on positive results from several clinical trials. It is given by a cycle of IV infusions once per year. The FDA asked the company to resubmit its application.

    Tysabri® label updated to include lab test to enhance treatment decisions – The test detects antibodies to the JC virus and can help determine a person’s risk of developing PML, a severe brain infection that has emerged in some people who have taken Tysabri (natalizumab, Biogen Idec
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