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National Cancer Institute Study to Determine the Optimal Time for CLL Patients to Begin Treatment
Date:12/4/2007

ically a slowly progressing cancer but up to 30 percent of patients with CLL progress rapidly," said Mara Aspinall, president of Genzyme Genetics. "By proactively testing for the IgVH mutation soon after initial diagnosis, doctors can identify high-risk patients and consider starting treatment earlier, possibly resulting in patients living longer."

Richard L. Schilsky, M.D., professor of medicine at the University of Chicago and chairman of the CALGB commented, "CALGB is pleased to partner with Genzyme in this important and novel study that will help to individualize the treatment of CLL."

Genzyme's participation in this study reinforces the company's commitment to furthering the role of diagnostics in the area of personalized medicine. Genzyme has been addressing the need for personalized treatment by developing tests to help physicians select appropriate therapies for their patients. Today Genzyme offers 18 innovative tests to help physicians guide treatment and save critical time for their patients with cancer.

The CALGB study will be open to its affiliate centers in the United States as well as Eastern Cooperative Oncology Group and Southwest Oncology Group sites.

About Chronic Lymphocytic Leukemia

CLL is the most prevalent form of adult leukemia, affecting approximately 120,000 people in Europe and the United States. The disease is most commonly diagnosed among people age 50 or older. CLL is characterized by the accumulation of functionally immature white blood cells (lymphocytes) in the bone marrow, blood, lymph tissue, and other organs. Two types of lymphocytes are present in the blood, B cells and T cells. About 95 percent of CLL cases involve cancerous B cells. Because these B cells have a longer than normal life span, they begin to build up and "crowd out" the normal, healthy blood cells. The accumulation of functionally immature cells in the bone marrow excludes the generation of healthy cells and can become fatal. Sympt
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SOURCE Genzyme Corporation
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