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National Brain Tumor Society Responds to Results of Avastin Clinical Trials
Date:6/3/2013

Boston, MA (PRWEB) June 03, 2013

National Brain Tumor Society, the largest nonprofit in the United States dedicated to the brain tumor community, issues the following statement regarding clinical trial results involving the cancer drug Avastin reported at the American Society of Clinical Oncology’s 2013 Annual Meeting:

"Beginning in May of 2009, drug maker Genentech received accelerated approval from the U.S. Food and Drug Administration (FDA) to market Avastin (bevacizumab) for the treatment of recurrent glioblastoma multiforme (GBM). National Brain Tumor Society has since followed the progress of Genentech’s required post-market study of Avastin called AVAglio, and has also sought input from the brain tumor community about the role Avastin has played as one of only four approved brain cancer drugs.

National Brain Tumor Society is deeply disappointed in the recently announced results of the AVAglio clinical trial. This trial revealed that Avastin (in combination with standard of care treatments) did not significantly prolong the lives of newly diagnosed GBM patients.

We are equally concerned with additional findings from a large, National Cancer Institute (NCI)-supported clinical trial conducted by the Radiation Therapy Oncology Group (RTOG). Similar to the AVAglio trial, the RTOG study did not show statistically significant increases in overall survival for newly diagnosed GBM patients taking Avastin in combination with standard of care treatments. Data from the AVAglio and RTOG studies collectively have provided mixed results on issues such as progression-free survival (i.e. a measure of tumor growth in response to a therapy) and quality of life, which will require careful and further analysis to better understand their full meaning in terms of patient care.

Avastin is an important part of the current limited treatment landscape for many brain cancer patients. National Brain Tumor Society
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