Participating researchers and investigator teams for key projects within Defeat GBM will initially stem from institutions such as: MD Anderson and Ludwig Institute for Cancer Research. The Initiative will also actively collaborate with the National Foundation for Cancer Research (NFCR) on a parallel bioinformatics and GBM genomics project, which capitalizes on NFCR's longstanding relationship with the Tissue Bank Consortium in Tianjin, China.
Additional and unique aspects of this program are the simultaneous research efforts in basic discovery science, translational science, pre-clinical drug development, and clinical trial design, all intended to identify the right biological targets and attack them with the right therapies in the right patients. To illustrate, one research project performs an exhaustive search to identify specific mechanisms of resistance (and acquired resistance) to existing therapies. As this project produces potential targets, another group of investigators (who have been screening drug candidates – both existing, and new compounds developed “in-house” by Defeat GBM researchers) will be prepared to test candidates (individually and in combination) on the new (and already known) targets both in vitro and in vivo (mouse models). Then, a third project, which had concurrently been investigating predictive biomarkers of response and resistance, will be ready to stratify patients into clinical groupings for its Smart Clinical Trials based on the targeted therapies developed through the work of the first groups.
The cumulative efforts of the collaborative framework, the combined scientific expertise, and the common scientific goal among all participants, should allow Defeat GBM to advance a therapy to the clinic that will make a meaningful difference for those suffering from this terrible disease and their families.
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