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Nasal Vaccine for Smallpox Confers High Levels of Immunity Without Safety Risks
Date:2/26/2008

cosal adjuvant for multivalent HIV vaccines."

Both the HIV and vaccinia vaccine studies demonstrate that vaccinated animals developed mucosal and systemic immunity as well as cellular immunity, whereby specific immune cells (CD8 and CD4 T cells) were successfully primed to recognize and destroy infected cells in the body.

Cellular immunity kills infected cells in the body and essentially removes the infection machinery of the virus. Previous HIV vaccines have focused on inducing cellular immunity but not mucosal immunity, said Baker. The more types of immunity generated by a vaccine, the higher the level of protection and infection-fighting capability the vaccine can provide.

NanoBio is in various stages of testing its pipeline of nasally delivered vaccines. Human testing of the influenza and hepatitis B vaccines are being planned, and data from ferret studies on the influenza vaccine are expected this quarter.

About NanoBio

NanoBio(R) Corporation is a privately held biopharmaceutical company focused on developing and commercializing anti-infective products and mucosal vaccines derived from its patented NanoStat(TM) technology platform. The company's lead product candidates are topical treatments for herpes labialis (cold sores), onychomycosis (nail fungus), MRSA and mucosal vaccines for influenza and hepatitis B. The company's headquarters and laboratory facilities are located in Ann Arbor, Mich.


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