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Nasal Vaccine for Smallpox Confers High Levels of Immunity Without Safety Risks
Date:2/26/2008

Data published in February issue of Clinical and Vaccine Immunology

ANN ARBOR, Mich., Feb. 26 /PRNewswire/ -- Scientists at NanoBio Corporation and the University of Michigan have demonstrated their nasally delivered vaccinia vaccine can protect animals against 77 times the potentially lethal dose of smallpox, and without the safety risks of current vaccines for smallpox. Vaccinia virus is related to smallpox virus and builds immunity against it.

The new vaccine confers a high level of safety because it contains inactivated vaccinia virus, not the live virus contained in current smallpox vaccines, according to the scientists. Live viruses can elicit adverse reactions; yet previous attempts to use inactivated virus have failed to rouse an adequate immune response against smallpox, the scientists said.

The current study in mice demonstrates that NanoBio's killed-virus vaccine elicits a robust immune response because it delivers immune-alerting antigens directly to the lining of the nasal mucosa, where the virus first enters the body. Immune cells inside the nose immediately recognize the foreign invader and quickly build an immune response against it, a process known as "mucosal" immunity.

Mucosal immunity provides a critical first response against respiratory viruses, yet injected vaccines do not induce mucosal immunity, said James R. Baker Jr., M.D. founder and chairman of NanoBio Corporation. NanoBio is a spin-off from the University of Michigan.

"The key finding is that we have validated in animals a new means of immunization that produces a unique and highly effective immune response without the potential risks of smallpox vaccination that are no longer considered acceptable in the population at large," said Baker.

"The safety and speed of our nasally delivered vaccine would provide the necessary protection to the public in the event of a bioterrorist attack or a natural outbreak of a related orthopoxvirus infectio
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SOURCE NanoBio Corporation
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