Navigation Links
Nanotechnology innovation may revolutionize gene detection in a single cell
Date:1/10/2008

g, single-stranded viral DNA scaffold can be folded and stapled by a large number of short synthetic helper strands into nanostructures that display complex patterns.

But the potential of structural DNA nanotechnology in biological applications has been underestimated, and if we look at the process of DNA self-assembly, you will be amazed that trillions of DNA nanostructures can form simultaneously in a solution of few microliters, and very importantly, they are biocompatible and water soluble, said Yan.

DNA chip and microarray technology have become a multi-billion dollar industry as scientists use it to examine thousands of genes at the same time for mutations or uncovering clues to disease. However, because DNA probes are pinned to the solid surface of the microarray chips, it is relatively slow process for the targets to search and find the probes. Also, it is hard to control the distances between the probes with nanometer accuracy.

In this work, we developed a water soluble nanoarray that can take advantage of the DNA self-assembling process and also have benefits that the macroscopic DNA microchip arrays do not have, said Yan. The arrays themselves are reagents, instead of solid surface chips.

To make the DNA origami RNA probes, Yan has taken advantage of the basic DNA pairing rules in the DNA chemical alphabet (A can only form a zipper-like chemical bond with T and G only pair with C). By controlling the exact position and location of the chemical bases within a synthetic replica of DNA, Yan programmed a single stranded genomic DNA, M13, into nanotiles to contain the probes for specific gene expression targets.

Yan refers to the self-assembled DNA nanoarrays as nucleic acid probe tiles, which look like a nanosized postage stamp. In a single step, the M13 scaffold system can churn out as many as 100 trillion of the tiles with close to100 percent yield.

Yans team designed three different DNA probe til
'/>"/>

Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Stevens to host Nanoscience/Nanotechnology & Corrosion symposium, Nov. 13
2. NASA technology forms the basis for a new nanotechnology company
3. Superbugs, shapes and nanotechnology
4. Siemens and Xintek Form Joint Venture to Develop Nanotechnology-Enabled Multi-Pixel X-ray Tubes
5. Commercialization of nanotechnology
6. National Nanotechnology Initiative releases new strategic plan
7. Elekta Demonstrates Commitment to Stereotactic Innovation at EANS
8. Elekta To Showcase Innovations in Radiotherapy and Unveil New Product That Expands Cancer Treatment Availability
9. Aware Celebrates Fifteen Years of Innovation and Leadership in the Biometrics Industry
10. Alliance for Medical Devices, Instrumentation and Diagnostics formed between Fraunhofer Center for Manufacturing Innovation and Boston University
11. Atrium Innovations Announces Management Changes
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanotechnology innovation may revolutionize gene detection in a single cell
(Date:8/20/2014)... August 20, 2014 WriteResult®, a leading ... that it has expanded its myPROpad™ ePRO tablet with ... one of the most widely used and well-respected ... health status. The EQ-5D is used during clinical trials ... measure that can be used to demonstrate Health-Related Quality ...
(Date:8/19/2014)... NJ (PRWEB) August 20, 2014 ... and regenerative medicine is an inadequate vascular supply. ... constructs and decellularized tissues is critical for successful ... have attempted to mitigate deficiencies in vascularization and ... adding scaffold bioactivity, optimizing scaffold design and architecture, ...
(Date:8/19/2014)... Aug. 19, 2014 Research and Markets  has announced ... Global Strategic Business Report" report to their offering. ... Culture Supplies in US$ Thousands by the following Product Segments: Media, ... for the US, Canada , Japan ... , and Latin America . Annual estimates and ...
(Date:8/19/2014)... Cellgen Diagnostics today launched ... a corporate lab for its genetic-based medical testing ... a critical component in the move from today’s ... of personalized medicine – a more predictive, preventive, ... contributions will support Cellgen’s intent to develop the ...
Breaking Biology Technology:EQ-5D™ Assessment Now Available for iPad 2Vascularization in Tissue Engineering Highlighted at 12th New Jersey Symposium on Biomaterials Science 2Global Cell and Tissue Culture Supplies - Strategic Business Report 2014 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 2Cellgen Diagnostics Launches Indiegogo Crowdfunding Campaign for DNA Medical Testing Device 3
... has developed an imaging system that quickly maps the ... for exampleat scales on the order of billionths of ... way to design and characterize mixed nanoscale materials such ... mapper uses custom software and electronics to process data ...
... Mumbai, WILMINGTON, N.C., Dec. 12 PPD, ... Mathew, M.D., as director,of strategic development, to lead ... Dr. Mathew will provide strategic leadership for ... clinical project management,and patient recruitment for key therapeutic ...
... maintain successful partnerships, patient, recruitment expertise and its ... CINCINNATI, Dec. 12 Kendle (Nasdaq: KNDL ... today,announced it was named "Best CRO" at the ... selected from among leading global CROs by a,distinguished ...
Cached Biology Technology:NIST imaging system maps nanomechanical properties 2Mathew to Lead PPD Drug Development Operations and Expansion in India 2Mathew to Lead PPD Drug Development Operations and Expansion in India 3Kendle Named Best CRO for Second Consecutive Year by Leading Global Pharmaceutical Publication Scrip 2
(Date:8/19/2014)... to decrease China,s increasing caesarean section rate, suggests a ... An International Journal of Obstetrics and Gynaecology (BJOG) . ... rates in the world. Of 16 million babies born ... exact rate is not known, the current Chinese language ... rates ranging from 36% to 58%. However, before the ...
(Date:8/19/2014)... a monkey. It,s not a lemur. It,s not an African ... tarsier: a tiny, adorable and downright "cool" primate from Southeast ... are familiar with," said Rafe Brown, curator-in-charge at the University ... ears; an extremely cute, furry body; a long tail with ... and toe tips that look a bit like the disks ...
(Date:8/19/2014)... abstinence syndrome (NAS) secondary to in-utero opioid exposure ... than others, but the underlying reasons are not ... are turned on or off) changes have recently ... University School of Medicine (BUSM) and Boston Medical ... study to identify some of these epigenetic changes ...
Breaking Biology News(10 mins):Is China's 50 percent cesarean section delivery rate too high? 2Is China's 50 percent cesarean section delivery rate too high? 3Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 2Philippine tarsier gets boost from Kansas research, and genetic proof of a new variety 3In-utero methadone, Subutex exposure could alter gene expression, cause severe Neonatal Abstience Syndrome 2
... focussing on innovative technologies and business tie-ups to promote ... the water industry. Some 200 representatives from ... latest in water technologies and to explore new opportunities ... Gracing the inaugural UK-Singapore Water Futures Forum ...
... Professor Jens Reich of the Max Delbrck Center for ... Carl Friedrich von Weizscker Award of the National Academy ... Wissenschaft. The physician, bioinformatician, molecular biologist and GDR civil ... achievements and his personal and political courage. The award ...
... mapped the sex chromosomes of several species of cichlid ... mechanism by which new sex chromosomes may evolve. ... journal Science , biologists Thomas Kocher, Reade Roberts ... the genetic basis for two co-existing systems of sexual ...
Cached Biology News:Nanyang Technological University and UK partners heightens cooperation in water industry 2Nanyang Technological University and UK partners heightens cooperation in water industry 3Professor Jens Reich first recipient of the Carl Friedrich von Weizsacker award 2Professor Jens Reich first recipient of the Carl Friedrich von Weizsacker award 3East African cichlid fish offer new understanding of genetic basis of sex determination 2
... compatible with hood installations. ... system for 384-well plates, ... prepares large quantities of ... Wellpro also performs plate ...
MBS 384 well satellite block unit with height adjusting heated lid, 384 well block holds 1 x 0.04 ml 384 well plate...
... structure has been determined, the challenge is ... diverse audience of scientists, educators and students. ... dissemination over the Internet, either via online ... Printed literature has the advantage of wide ...
... 45° Fixed Angle rotor for ... CL2, Centra CL3/CL3R, HN-SII or ... style rotor accepts 15 mL ... disposable conical tubes as well ...
Biology Products: