Navigation Links
Nanosized technology has supersized effect on tumors
Date:4/4/2008

Anyone facing chemotherapy would welcome an advance promising to dramatically reduce their dose of these often harsh drugs. Using nanotechnology, researchers at Washington University School of Medicine in St. Louis have taken a step closer to that goal.

The researchers focused a powerful drug directly on tumors in rabbits using drug-coated nanoparticles. They found that a drug dose 1,000 times lower than used previously for this purpose markedly slowed tumor growth.

"Many chemotherapeutic drugs have unwanted side effects, and we've shown that our nanoparticle technology has the potential to increase drug effectiveness and decrease drug dose to alleviate harmful side effects," says lead author Patrick M. Winter, Ph.D., research assistant professor of medicine and biomedical engineering.

The nanoparticles are extremely tiny beads of an inert, oily compound that can be coated with a wide variety of active substances. In an article published online in The FASEB Journal, the researchers describe a significant reduction of tumor growth in rabbits that were treated with nanoparticles coated with a fungal toxin called fumagillin. Human clinical trials have shown that fumagillin can be an effective cancer treatment in combination with other anticancer drugs.

In addition to fumagillin, the nanoparticles' surfaces held molecules designed to stick to proteins found primarily on the cells of growing blood vessels. So the nanoparticles latched on to sites of blood vessel proliferation and released their fumagillin load into blood vessel cells. Fumagillin blocks multiplication of blood vessel cells, so it inhibited tumors from expanding their blood supply and slowed their growth.

Human trials have also shown that fumagillin can have neurotoxic side effects at the high doses required when given by standard methods. But the fumagillin nanoparticles were effective in very low doses because they concentrate where tumors create ne
'/>"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Spherix Shareholders Support Companys Focus on Naturlose, Biotechnology
2. Novel Technology Breaks Through Cancer Pain
3. Amyris Biotechnologies Co-Founder Neil Renninger Named to Technology Reviews Prestigious TR35 List of Top Young Innovators
4. Advanced Cell Technology Announces Proposed Financing
5. Advanced Cell Technologys Dr. Robert Lanza Makes List of 100 Most Inspiring People in the Life-Sciences Industry
6. Operon Biotechnologies and DNA2.0 Announce Co-Marketing and Technology Development Partnership
7. BioMarin Licenses Technology From Leading Cystic Fibrosis Research Laboratory at the University of California, San Francisco
8. Microchip Biotechnologies, Inc. Secures Exclusive License to Use New University of Alberta Technology for Developing Microfluidic Devices
9. MedImmune Licenses Reverse Genetics Technology to Novartis for Use in Influenza Vaccine Development and Production
10. China Technology Announces New Chief Financial Officer
11. Medinet Licenses MaxCyte Cell Loading Technology for Cancer Immunotherapy in Japan
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Nanosized technology has supersized effect on tumors
(Date:7/25/2014)... Pa. , July 25, 2014 /PRNewswire-iReach/ -- ... and consulting for global corporations operating in highly ... host its first annual Global User Group Conference, ... historic Philadelphia, Pennsylvania at ... - http://photos.prnewswire.com/prnh/20140724/130263 This ...
(Date:7/24/2014)... RIDGE, Tenn., July 24, 2014 -- A novel combination ... the Department of Energy,s Oak Ridge National Laboratory an ... for its unusual physical and electrochemical properties. , ... how oxygen affects the surface of a perovskite manganite, ... behavior. The new avenue to understand surface behavior could ...
(Date:7/24/2014)... 24, 2014  ECC West Africa, LLC (ECC) signed ... with University College Hospital (UCH) Ibadan Board of Management ... finance, design, construct, and operate and maintain a new, ... . Under the first of the 4-phase project, ECC ... funding applications. UCH Ibadan intends to finance and develop ...
(Date:7/24/2014)... Engineering at the University of Delaware, is known ... energy engineering, environmental sustainability and electronics. , His ... with a well-defined, crystalline structure. At the atomic ... that zeolites can separate molecules with size differences ... of a nanometer), making them useful to the ...
Breaking Biology Technology:Xybion Announces It Will Host International User Conference in Philadelphia 2Xybion Announces It Will Host International User Conference in Philadelphia 3ORNL study reveals new characteristics of complex oxide surfaces 2ECC Signs a Contract for the Finance, Design, and Construction of a Premier Cancer Institute in Ibadan, Nigeria 2University of Delaware researcher describes new approach for creating organic zeolites 2
... Sept. 30 DOR BioPharma, Inc. (OTC Bulletin Board: SNGX), ... a corporate name change from DOR BioPharma, Inc. to Soligenix, ... name change, the Company,s shares of common stock will immediately ... today. , "We are pleased to announce the ...
... 30 /PRNewswire-FirstCall/ - Quest PharmaTech Inc. (TSX-V: QPT) ... and commercializing products for the treatment of cancer, ... of late-stage immunotherapy product candidates from Paladin Labs ... candidates consists of five monoclonal antibodies targeting certain ...
... , ... application enables system access and security for federal employees, regardless of location , ... Miami, FL (PRWEB) September ... landmark partnership with the Ministry of Health in Spain, providing the agency with software-based ...
Cached Biology Technology:DOR BioPharma Announces Corporate Name Change to Soligenix and Begins Trading Under New Ticker Symbol 'SNGX' 2DOR BioPharma Announces Corporate Name Change to Soligenix and Begins Trading Under New Ticker Symbol 'SNGX' 3DOR BioPharma Announces Corporate Name Change to Soligenix and Begins Trading Under New Ticker Symbol 'SNGX' 4Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline 2Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline 3Quest PharmaTech Acquires Late-Stage Immunotherapeutic Antibody Pipeline 4Spain's Health Ministry Contracts Authenware to Fortify System Security Prior to Flu Season 2Spain's Health Ministry Contracts Authenware to Fortify System Security Prior to Flu Season 3
(Date:7/27/2014)... data," a single computer cannot always find the solution ... across a cluster of computers that analyze a massive ... your web history to present you with targeted ads, ... book or movie. But big data is about more ... brain activity are generating unprecedented quantities of information. That ...
(Date:7/25/2014)... raging this summer and some of the smoke from those ... image collected by the Moderate Resolution Imaging Spectroradiometer (MODIS) aboard ... smoke has descended over the Great Lakes region of the ... image from July 23, 2014 (first image feature highlighted below) ... off southeastward. In the image, it is over Manitoba ...
(Date:7/25/2014)... consume the healthcare community and remain priority ... To address the worldwide crisis of obesity ... global leaders in diabetes, epidemiology and public ... and development of diverse intervention programs in ... This book on "Global Health Perspectives in ...
Breaking Biology News(10 mins):New tools help neuroscientists analyze 'big data' 2New tools help neuroscientists analyze 'big data' 3New tools help neuroscientists analyze 'big data' 4New tools help neuroscientists analyze 'big data' 5What constitutes an effective response to the global 'diabesity' tsunami? 2
... first used clinically, scientists can finally get a detailed, ... This receptor hails from a family of proteins called ... several of our senses, and the action of about ... known structure of a human GPCR, the work promises ...
... Researchers at Purdue and Duke universities have developed ... selectively separate tiny magnetic particles, representing a highly ... samples from patients. Because different pathogens could ... new technique can selectively separate particles by size, ...
... concludes that increasing levels of ozone due to the ... resulting in serious costs to the world,s economy. ... Energy Policy, focused on how three environmental changes (increases ... activity will affect crops, pastures, and forests. ...
Cached Biology News:Scientists unveil structure of molecular target of many drugs 2New system would use rotating magnetic field to detect pathogens 2New system would use rotating magnetic field to detect pathogens 3New system would use rotating magnetic field to detect pathogens 4MIT: Human-generated ozone will damage crops 2MIT: Human-generated ozone will damage crops 3
... Persistent Analysis Environment 2) Dot plot, ... 3) Software Compensation 4) Cell Cycle ... Platform 7) Intelligent batch generation of graphs ... 9) Single drag-and-drop operations to perform complex ...
Eagle's Ham's amino acids; EHAA...
... The proteomic service includes protein separation ... using the PDQuest software package from ... mass spectrometry. In order to meet ... preparation, data analysis and format of ...
... Leptin is a proteohormone with a molecular weight ... by the ob gene and produced by adipocytes [1,2]. ... in the regulation of body weight [1-3]. In ... in both men and women [4]. A relationship ...
Biology Products: