Navigation Links
Nanomedical Diagnostics to Present Field Effect Biosensing for Fragment-Based Drug Discovery at SLAS 2017
Date:1/24/2017

Nanomedical Diagnostics, a biotech company pioneering the development of label-free graphene biosensor assays for fragment-based screening, will showcase its proprietary Field Effect Biosensing (FEB) technology in booth 1317 at the 2017 Society for Laboratory Automation and Screening (SLAS) conference in Washington, D.C. from Feb. 6 to Feb. 8.

Fragment-based drug discovery (FBDD) is increasingly used in the pharmaceutical industry as a complementary approach to traditional high-throughput screening (HTS). As opposed to HTS libraries of one-million small molecule compounds, FBDD screens can contain just 2000 low molecular weight fragments. In FBDD, researchers employ label-free biophysical techniques such as surface plasmon resonance (SPR), nuclear magnetic resonance (NMR) spectroscopy, and X-ray crystallography as primary screening methodologies, but the low molecular weight of fragments and the solvents used to dissolve them can hinder accurate hit identification.

Nanomedical Diagnostics will introduce a real-time, label-free detection method that is based on electronics, providing a strong orthogonal approach for screening and hit validation. FEB excels in detecting molecules with large charge-to-mass ratios which enables sensing of compounds with no lower size limit, a considerable benefit in fragment-based screening. The non-optical technique measures the current across a field effect surface to which the target is immobilized. Any interaction or binding that occurs on the biosensor surface causes a change in conductance that is monitored in real time, providing accurate kinetic and affinity data.

“Because Field Effect Biosensing measures electrical changes instead of mass, the technology can sense in solutions such as DMSO which cause a high level of background noise on optical sensors. We have detected in 10% DMSO with no effect,” says Nanomedical Diagnostics CEO, Ross Bundy. “This provides an excellent alternate methodology for researchers who struggle to measure in complex solvents that are necessary for their candidate compounds.”

The small size of FEB technology lends to high-throughput when coupled with automatic liquid handling systems. “We estimate that a 3000-compound fragment library can be screened in one eight-hour shift on a single 96-well system,” continues Mr. Bundy. “Combined with the wide dynamic range of the platform, FEB technology can be used not only for hit identification, but also for assay development and lead optimization. The ability to use the same methodology across the drug discovery process vastly reduces assay optimization time, enabling a shorter timeline to preclinical trials.”

At SLAS2017, Nanomedical Diagnostics will showcase FEB technology with its first product, AGILE R100. For more information, visit http://www.nanomedicaldiagnostics.com.

About Nanomedical Diagnostics

Nanomedical Diagnostics (“Nanomed”) is a biotech company based in San Diego, CA. Nanomed has developed a breakthrough electronic assay based on Field Effect Biosensing (FEB) technology that provides real-time, label-free kinetic binding and affinity data. Biosensors at the heart of the assay leverage the highly sensitive nanomaterial graphene to unite biology with electronics, delivering the unique ability to sense molecules with no lower size limit in complex media such as DMSO, and use unprecedentedly small amounts of sample.

Read the full story at http://www.prweb.com/releases/Nanomedical_Diagnostics/SLAS2017/prweb14007568.htm.


'/>"/>
Source: PRWeb
Copyright©2017 Vocus, Inc.
All rights reserved


Related biology technology :

1. Nanomedical Diagnostics Announces Scientific Advisory Board of Top Scientists and Medical Researchers
2. Nanomedical Diagnostics launches a new graphene biosensor with unprecedented functionality for small molecule and protein analysis
3. Nanomedical Diagnostics CEO and CTO to Introduce Electronic Label-Free Assay Based on Field Effect Biosensing Technology at IDTechEx Show
4. DMG is Proud to Announce that CD Diagnostics will be Featured in an Upcoming Episode of Health Heroes
5. Boston Heart Diagnostics Awarded $450,000 in Tax Incentives from the Massachusetts Life Sciences Center
6. PrimeraDx to Co-Develop Companion Diagnostics with Quest Diagnostics
7. Dominion Diagnostics to Sponsor 2013 Addiction Professional Panel Series as Thought Leadership Partner
8. MGC Diagnostics Corporation Announces Special Cash Dividend and Extension of Stock Repurchase Program
9. Slone Partners CEO & President Speak about Hiring Challenges in Molecular Diagnostics at Executive War College 2013
10. Advanced Animal Diagnostics Raises $6 Million for On-farm Diagnostics
11. Isothermal Nucleic Acid Amplification Technologies Market 2012-2017: Molecular Diagnostics, Infectious Disease Testing, Blood Screening, Cancer Research, Rapid Testing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... May 24, 2017 , ... Today, the South Davis ... Advanced Biological Nutrient Recovery (ABNR™) technology at its 4,000,000 gallon per day South ... to sustainably meet current and future nutrient discharge regulations. The ABNR platform, which ...
(Date:5/24/2017)... Ebola resurfaces in the Democratic Republic of Congo ... reported, a new analysis of the Ebola gene polymerase Replikin ... 2014 and 2017 outbreaks of the disease.  ... the 2014 outbreak. An analysis of the latest data showed ... which again precedes the current outbreak in the DRC. Sequence ...
(Date:5/23/2017)... ... 2017 , ... Genedata, a leading provider of advanced software ... a strong presence at Bio-IT World Conference & Expo 2017 in Boston, MA. ... all attendees to view posters on the entire range of Genedata software ...
(Date:5/23/2017)... ... May 23, 2017 , ... Energetiq Technology, ... announced a facility expansion to accommodate its rapid growth. , The renovations at ... and renovation of the existing areas. The expansion includes, a state-of-the-art engineering facility, ...
Breaking Biology Technology:
(Date:3/28/2017)... , March 28, 2017 ... Biometrics), Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video ... and Region - Global Forecast to 2022", published by ... in 2016 and is projected to reach USD 75.64 ... 2017 and 2022. The base year considered for the ...
(Date:3/23/2017)... 2017 The report "Gesture Recognition and Touchless Sensing Market ... - Global Forecast to 2022", published by MarketsandMarkets, the market is expected to ... between 2017 and 2022. Continue Reading ... ... ...
(Date:3/22/2017)... LIVERMORE, Calif. , March 21, 2017 ... recognition analytics company serving law enforcement agencies, announced today ... Sheridan as director of public safety business development. ... of diversified law enforcement experience, including a focus on ... Vigilant. In his most recent position, Mr. Sheridan served ...
Breaking Biology News(10 mins):