Navigation Links
Nano detector for deadly anthrax
Date:8/14/2011

An automatic and portable detector that takes just fifteen minutes to analyze a sample suspected of contamination with anthrax is being developed by US researchers. The technology amplifies any anthrax DNA present in the sample and can reveal the presence of just 40 microscopic cells of the deadly bacteria Bacillus anthracis.

B. anthracis, commonly known as anthrax, is a potentially lethal microbe that might be used intentionally to infect victims through contamination of food and water supplies, aerosolized particles, or even dried powders, such as those used in bioterrorist attacks in the USA. Detection is crucial to preventing widespread fatalities in the event of an anthrax attack. However, the complexity of the microbe's biology have so far made it difficult to build a portable system that can be employed quickly in the field. That said, there are several systems available that use PCR to amplify a particular component of the genetic material present in anthrax and then to flag this amplified signal. These systems are fast and sensitive but do not integrate sample preparation and so are not as convenient as a single detector unit would be.

Writing in the International Journal of Biomedical Nanoscience and Nanotechnology this month, Nathaniel Cady of the College of Nanoscale Science and Engineering (CNSE) of the University at Albany and colleagues there and at Cornell University, New York, explain how they have constructed nanofabricated fluidic cartridges that can be used to carry out detection of anthrax. The device is a so-called "lab-on-a-chips" device, or more properly a 3D microfluidic network that contains nanofabricated pillar structures.

The device has fluidic inputs for adding sample and reagents, removing waste, for carrying out DNA purification, and critically an integrated chamber for amplifying only the target DNA in the sample using the polymerase chain reaction (PCR) system. The chip also contains a wave guide for the fluorescence-based identification of the amplified DNA and thus the target microbe. Importantly, the system works without manual intervention other than loading a droplet of sample into the detector.

"The average time required for DNA purification during these experiments was approximately 15 min, and when combined with real-time PCR analysis, this resulted in an average time to detection of 60 min," the team says. The system can detect as few as 40 B. anthracis cells. "Due to its small size and low power requirements, this system can be further developed as a truly portable, hand-held device," the researchers conclude.


'/>"/>

Contact: Nathaniel C. Cady
ncady@uamail.albany.edu
Inderscience Publishers
Source:Eurekalert

Related biology technology :

1. Livermore researchers develop battery-less chemical detector
2. Ultra fast photodetectors out of carbon nanotubes
3. Rice physicists discover ultrasensitive microwave detector
4. Extreme darkness: Carbon nanotube forest covers NISTs ultra-dark detector
5. Looking to leap forward on laser and photodetector technologies
6. Nikon Instruments Introduces Exclusive VAAS Detector Imaging Method for Confocal Microscopy
7. Making blood-sucking deadly for mosquitoes
8. Computational Microbiologist Uses His Expertise with Deadly Viruses to Devise a Superior System for Delivery of Safe, Free Software Downloads
9. Detection of potentially deadly atrial fibrillation dramatically improved by new algorithm
10. Germgards Ultra-Fast Hand Hygiene Solution Protects Against Deadly MRSA, C difficile, and Influenza Virus
11. PharmAthene Achieves Anthrax Vaccine Program Milestone and Successfully Completes Technology Transfer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/11/2016)... ... February 11, 2016 , ... ... new stem cell treatment clinic in Quito, Ecuador. The new facility will provide ... applications to patients from around the world. , The new GSCG clinic ...
(Date:2/10/2016)... Ky. , Feb. 10, 2016 NX ... utilizing its proprietary NeXosome® technology for early warning ... of its most recent study by Dr. ... at the Society for Maternal Fetal Medicine,s (SMFM) annual ... GA, February 1-6 th , 2016.  The presentation reported ...
(Date:2/10/2016)... plc (NYSE: AGN ) a leading global pharmaceutical ... CEO and President, will be featured as the keynote ... Capital Markets Healthcare Conference on Tuesday, February 23, 2016 ... Hotel in New York, NY . ... accessed on Allergan,s Investor Relations web site at ...
(Date:2/10/2016)... ... ... LATHAM, NEW YORK... Marktech Optoelectronics will feature their new high-speed InGaAs ... Moscone Center from February 16-18, 2016, and at the healthcare-focused BiOS Expo on February ... standard packages feature a TO-46 metal can with active areas of 1.0mm and 1.5mm ...
Breaking Biology Technology:
(Date:1/27/2016)... CHESTER, Ohio , Jan. 27, 2016  Rite ... supplier based in West Chester, Ohio ... their award winning service staff, based in ... technical capacity and ability to provide modifications, installations and ... John Dovalina , CEO of PLUS, commented, "PLUS has ...
(Date:1/22/2016)... DUBLIN , January 22, 2016 ... has announced the addition of the  ... to their offering. --> ... of the  "Global Behavioral Biometric Market ... --> Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ...
(Date:1/20/2016)... Jan. 20, 2016 A market that just ... benefit from the explosion in genomics knowledge. Learn all ... Research. A range of dynamic trends are pushing market ... personalized medicine - pharmacogenomics - pathogen evolution - next ... markets - greater understanding of the role of genetic ...
Breaking Biology News(10 mins):