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Naglazyme Approved by Brazil's National Health Surveillance Agency
Date:2/3/2009

; and those factors detailed in BioMarin's filings with the Securities and Exchange Commission, including, without limitation, the factors contained under the caption "Risk Factors" in BioMarin's 2007 Annual Report on Form 10-K, as amended, and the factors contained in BioMarin's reports on Form 10-Q and Form 8-K. Stockholders are urged not to place undue reliance on forward-looking statements, which speak only as of the date hereof. BioMarin is under no obligation, and expressly disclaims any obligation to update or alter any forward-looking statement, whether as a result of new information, future events or otherwise.

BioMarin(R), Naglazyme(R) and Kuvan(R) are registered trademarks of BioMarin Pharmaceutical Inc.

Aldurazyme(R) is a registered trademark of BioMarin/Genzyme LLC.

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    Investors                                    Media
    Eugenia Shen                                 Susan Berg
    BioMarin Pharmaceutical Inc.                 BioMarin Pharmaceutical Inc.
    (415) 506-6570                               (415) 506-6594


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