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NPS Pharmaceuticals Announces Approval of Cinacalcet HCl in Japan
Date:10/25/2007

BEDMINSTER, N.J., Oct. 25 /PRNewswire-FirstCall/ -- NPS Pharmaceuticals, Inc. (Nasdaq: NPSP) announced today the approval of cinacalcet hydrochloride by the Japanese Pharmaceuticals and Medical Devices Agency for the treatment of secondary hyperparathyroidism. As a result, NPS will receive a milestone payment plus royalties from Kirin Pharma, a wholly owned subsidiary of Kirin Holdings, which will market the drug in Japan. Kirin licensed cinacalcet from NPS in 1995 for development and commercial sale in Japan, China, North and South Korea, and Taiwan.

Cinacalcet is an oral medication for the treatment of secondary hyperparathyroidism in patients with chronic kidney disease on dialysis. It regulates the over-secretion of parathyroid hormone (PTH) in patients with chronic kidney insufficiency by acting directly on the parathyroid gland calcium-sensing receptor. Elevated levels of PTH, the hallmark of secondary hyperparathyroidism, are associated with altered metabolism of calcium and phosphorus, bone pain, fractures, and an increased risk for cardiovascular death. The drug is currently marketed in the United States and Europe by Amgen as a treatment for this condition and for the treatment of elevated levels of calcium in patients with parathyroid carcinoma.

NPS president and CEO Dr. Tony Coles stated: "We congratulate our partner Kirin Pharma for obtaining approval to market cinacalcet in Japan as a treatment for secondary hyperparathyroidism. This first-in-class compound treats a serious complication of chronic kidney disease for which patients in Japan with this condition have had no therapeutic alternative."

Kirin Pharma general manager of strategic product planning, T. Oishi, stated: "Approximatel
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SOURCE NPS Pharmaceuticals, Inc.
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