Navigation Links
NOVAVAX Announces Preclinical Study Results for a Respiratory Syncytial Virus ('RSV') Vaccine Candidate Directed Against the Fusion (F) Protein
Date:2/27/2009

Preclinical Study Shows the Investigational RSV-F Virus-like Particle Vaccine Induced Neutralizing Antibodies and Protected Mice upon Challenge

ROCKVILLE, Md., Feb. 27 /PRNewswire-FirstCall/ -- Novavax, Inc. (Nasdaq: NVAX) announced results from a preclinical study of a Respiratory Syncytial Virus ("RSV") vaccine candidate directed against the viral fusion (F) protein. The virus utilizes the F protein to fuse with cells in the respiratory tract and cause illness. Novavax's RSV-F VLPs were made using a proprietary matrix (i.e., "core") protein decorated with the human RSV F protein. The VLPs mimic the three-dimensional structure of RSV but cannot replicate and cause disease because they contain no genetic material.

In this study, mice were vaccinated with two injections of RSV-F VLPs (10 microgram dose; no adjuvant), RSV-F VLPs with different adjuvants, inactivated RSV, live RSV, or a placebo. Neutralizing antibody responses against RSV, which are important for preventing infection and lower respiratory illness, were highest in the "VLP plus adjuvant" group; responses with VLPs alone were higher than responses observed with either live or inactivated RSV immunization. The VLPs induced strong cell mediated immune responses with activation of CD8+ cytotoxic T-lymphocytes against the F protein, which are important for protection because they kill cells infected with RSV. The RSV-F VLP vaccine candidate also protected against RSV infection, reducing the quantity of RSV virus found in the lungs of immunized mice after a challenge with live virus.

A monoclonal antibody against F protein with annual sales of $500 million is available that protects against RSV-related hospitalizations in infants and young children at high risk of severe disease. However, several injections are required and the lifespan of th
'/>"/>

SOURCE Novavax, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Novavax CEO to Present at BIO CEO & Investor Conference
2. Novavax Enters Into Estrasorb(R) Asset Sale and Supply Agreements with Graceway Pharmaceuticals, LLC
3. Graceway Pharmaceuticals, LLC(TM) Announces Completed Acquisition of All Assets Related to Estrasorb(R) Product Line in North America From Allergan, Inc. (NYSE: AGN) and Novavax, Inc. (Nasdaq: NVAX)
4. Novavax CEO to Present at the World Vaccine Congress 2008
5. Novavax Opens Its First U.S. Vaccine Plant
6. Novavax Announces Release Date of 2008 First Quarter Financial Results and Investor Conference Call
7. Novavax Reports First Quarter 2008 Financial Results
8. Novavax CEO to Present at ACUMENBioFins 5th Annual Global Healthcare Conference
9. Novavax CEO to Present at FBR Capital Markets 12th Annual Spring Investor Conference
10. Novavax CEO to Present at Piper Jaffray Europe Conference, London, UK
11. Novavax to Join Russell 3000 Index
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... , Dec. 24, 2014  Vermillion, Inc. ... on gynecologic disease, announced today that the Company ... including Oracle Investment Management, Jack W. Schuler ... Total proceeds were $10.5 million, before offering expenses.  ... and general corporate purposes. Under the ...
(Date:12/24/2014)... 2014 Earlier this year in a ... director of the Adult Stem Cell Technology Center, LLC ... and under appreciated unique property of adult tissue stem ... Cells: Misunderstood in the Past, Important for the Future,” ... He gave the address at the 4th World ...
(Date:12/24/2014)... The report provides basic ... definition, classification, application and industry overview. This ... and product cost structure. Production is separated ... also covers upstream raw materials, equipment, downstream ... and proposals. In the end, the export ...
(Date:12/24/2014)... , Dec. 23, 2014 China Biologic ... "Company"), a leading fully integrated plasma-based biopharmaceutical company ... that its majority-owned subsidiary, Shandong Taibang Biological Products ... certification from the China Food and Drug Administration ... facility. As previously disclosed in the Company,s public ...
Breaking Biology Technology:Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3
... Avantium Technologies announces the,launch of a new system to ... be marketed under the name,Crystalline. , ... need in the pharma,industry to learn as much as ... , "Avantium is proud to ...
... Cell Biosciences, Inc., a,provider of nanoproteomic analysis ... of its first kits for the analysis of ... The new kits are,optimized for characterization of proteins ... roles in cancer cell survival and proliferation. Drug ...
... for DNA-Guided Decision Support in Diabetes Drug TherapyHARTFORD, ... shown statistically significant associations of certain genes in ... (BMI) and edema (fluid retention) in patients taking ... study, co-authored with investigators from Joslin Diabetes Center ...
Cached Biology Technology:Avantium Launches the Crystalline, a New Parallel System for Crystallization Research 2Cell Biosciences Introduces Kits for Oncoprotein Analysis 2Cardiovascular Side Effects of Pioglitazone and Rosiglitazone Linked to Vascular and Energy Pathways by Genomas Clinical Study 2
(Date:12/10/2014)... 8, 2014 You,ve been here before: you desperately ... remember your password, site key or the answer to your ... grade teacher? Today, Hoyos Labs , ... that will finally put an end to the frustration that ... . 1U leverages a user,s smartphone to acquire his ...
(Date:12/10/2014)... , December 9, 2014 ... ITN,s BCARD Platform   ... enterprise meeting scheduling solutions for business-to-business (B2B) events, ... world leader in mobile near-field communication (NFC), Bluetooth ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow ...
(Date:12/3/2014)... As part of our commitment to offering ... to announce the release of a new reader that ... workforce data that they need. The Atlas ... existing readers. Many such devices have serious shortcomings when ... Older models force users to navigate numerous complicated steps ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Inception Technologies to Release New Biometric Reader 2
... from around the globe issued joint statements today to ... and innovation can play in the pursuit of sustainable ... threat of drug resistance in infectious agents including tuberculosis. ... leaders attending next month,s G8 Summit and other international ...
... exams might want to wait before pulling an all-night ... neurons are concerned. Carnegie Mellon University neuroscientists have discovered ... repeated exposure to a stimulus shrinks synapses. The findings ... Journal of Neuroscience . It,s well known ...
... by an international team of psychologists has shown that ... in brain activity guilt detection tests. Such tests, ... used by law enforcement agencies in several countries, including ... criminals will have specific memories of their crime stored ...
Cached Biology News:Science academies issue 'G-Science' statements to call world leaders' attention to global challenges 2Carnegie Mellon neuroscientists discover new phase of synaptic development 2People can 'beat' guilt detection tests by suppressing incriminating memories 2
Homo sapiens CDC23 (cell division cycle 23, yeast, homolog),...
Homo sapiens postsynaptic protein CRIPT Antigen: Recombinant Protein...
Immunogen: Synthetic Peptide: V(22) N G H E F E I E G E G E G R(36) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Human Cystatin F MAb (Clone 292103)...
Biology Products: