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NOVAVAX Announces Positive Preclinical Results for its Respiratory Syncytial Virus (RSV) Vaccine Candidate
Date:1/12/2010

d disease.  However, RSV-induced pathology in the lungs was observed in animals immunized with a formalin-inactivated RSV control.  

"We are excited to report steady progress towards the development of a vaccine against RSV, an important virus that is the leading cause of viral death in infants," said Dr. Rahul Singhvi, President and CEO of Novavax.  "A safe and effective vaccine against RSV is especially needed in very young children since RSV infection does not provoke lasting immunity.  An effective vaccine would also be important in adults, especially the elderly, where RSV illness is common.  There is currently no approved vaccine for the prevention of RSV and the market potential for such a vaccine could exceed $1 billion annually."(1)

In addition to completing this important preclinical study in cotton rats, Novavax today announced the successful scale up of the manufacturing process for the RSV-F vaccine candidate.   Material produced with this process under current Good Manufacturing Practices (cGMP) is currently being used in a formal toxicology study in rabbits.  

About Respiratory Syncytial Virus

RSV is the most commonly identified cause of lower respiratory tract illnesses in infants and young children.  Repeated infections occur throughout life causing moderate to severe cold-like symptoms.  More severe lower respiratory tract disease is also seen in elderly adults over age 65 years, similar to the severe illness witnessed in children. It is estimated that RSV infects more than 8.5 million adults annually, including the elderly over age 65 years. This virus is responsible for approximately 900,000 hospitalizations annually in the United States and major European countries. In the United States alone, RSV leads to 177,500 hosp
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SOURCE Novavax, Inc.
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