Navigation Links
NIH scientists show how anthrax bacteria impair immune response
Date:11/17/2010

WHAT: Researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have determined a key mechanism by which Bacillus anthracis bacteria initiate anthrax infection despite being greatly outnumbered by immune system scavenger cells. The finding, made by studying genetically modified mice, adds new detail to the picture of early-stage anthrax infection and supports efforts to develop vaccines and drugs that would block this part of the cycle.

To start an infection, anthrax bacteria release a toxin that binds to immune cells through two receptors, TEM8 and CMG2, found on the cell surface. The binding allows two additional bacterial toxins to enter the cells, setting off a chain of events that impairs their ability to ingest and kill the bacteria.

In the new research, NIAID investigators Stephen Leppla, Ph.D., Shihui Liu, M.D., Ph.D., and colleagues bred mice that lacked CMG2 receptors on two kinds of immune cells, neutrophils and macrophages. These usually are the first cells to arrive at the site of an anthrax infection, where they engulf the invading bacteria and try to prevent the spread of infection.

Mice without CMG2 receptors on these immune cells were completely resistant to infection by B. anthracis bacteria, experiencing only a temporary swelling at the site of infection, and fully clearing the infection within two weeks. In contrast, in normal mice, the level of anthrax bacteria increased rapidly in the 48 hours following infection, and all the mice died within six days.

The researchers concluded that B. anthracis uses CMG2 receptors to impair the scavenging action of neutrophils and macrophages during early infection, giving the bacteria time to multiply to levels sufficient to overwhelm the body's defenses. Developing drugs and vaccines that block B. anthracis from establishing early infection via binding to the CMG2 receptor, say the study a
'/>"/>

Contact: Anne A. Oplinger
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Clemson scientists put a (nano) spring in their step
2. City of Hope Helps KGI Launch New Management Training Program for Scientists
3. University of Pennsylvania scientists move optical computing closer to reality
4. Scientists grow nanonets able to snare added energy transfer
5. The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters
6. Scientists peel away the mystery behind golds catalytic prowess
7. SACHEM Launches 2-D HPLC e-Learning Program : New e-Learning Program Teaches Scientists How to Better Analyze and Prove Product Purity Through Greater Sensitivity and Precision in Identification of Trace Components
8. Vermillion and Stanford Scientists Receive Best Research Award From the PAD Coalition
9. Brewing better beer: Scientists determine the genomic origins of lager yeasts
10. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
11. CU scientists create worlds thinnest balloon -- just one atom thick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... news release is available in German . ... crystal around several quantum dots in a semiconductor layer. Quantum ... consequence of atomic processes. If a short laser pulse is ... and the quantum dot experiences a change in the electromagnetic ... down the emission of light by the dot. As soon ...
(Date:9/30/2014)... of one of nature,s most efficient light-harvesting structures, ... by Alejandro Briseno of the University of Massachusetts ... long-sought polymer architecture to boost power-conversion efficiency of ... , Briseno, with colleagues and graduate students ... and Dresden University of Technology, Germany, report in ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Shimadzu ... extensometer, an easy-to-use and highly precise tool for ... with considerable elongation. With 1000-mm maximum movement distance, ... percent for a gauge length of 10 mm. ... measurement accuracy above 50-mm stroke and within +/- ...
(Date:9/30/2014)... Proove Biosciences , the commercial and research ... new genetic test built upon research from their published ... will provide physicians with an objective way to understand ... stratified between individuals. With this new test, physicians will ... genetic predisposition that will affect their pain tolerance. , ...
Breaking Biology Technology:Ultrafast remote switching of light emission 2Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3Shimadzu’s New Long-Travel Extensometer Increases Precision for Soft Material Testing 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 2Proove Biosciences is Now Offering the Proove Pain Perception Genetic Test to Help Physicians Assess Patient Pain Tolerance Levels 3
... , Feb. 3 ERT (Nasdaq: ERES ), announced ... full year 2009 on Thursday, February 25, 2010 , after the ... at 5:00 PM EST that day. , For the ... United States or 1-412-858-4600 when calling internationally. There will be a ...
... GENEVA , February 3 Viroblock ... anti-viral products, today,announced that Dr. Jamie Paterson will join ... Jamie Paterson , a British national, can look back at 20 ... was,Chief Commercial Officer at Neurim Pharmaceuticals. During his 18 years at,Procter ...
... Molecular Imaging Summit wrapped up today in Albuquerque, ... energy looking ahead. Nanotechnology is a quickly ... for applying technology in highly targeted ways. For ... target diseaseand treat many common and devastating diseases ...
Cached Biology Technology:ERT to Announce Fourth Quarter and Full Year 2009 Results on February 25, 2010 2Viroblock SA Hires Dr. Jamie Paterson as CEO and Closes Financing Round 2SNM's nanomedicine summit advances molecular imaging 2SNM's nanomedicine summit advances molecular imaging 3
(Date:10/1/2014)... take a healthy salad up a level by growing ... in leafy greens. , "In the long run, one ... the salad or making a pill from the plant ... at Case Western Reserve School of Medicine and leader ... cancer organization is funding the research with a three-year, ...
(Date:9/30/2014)... Mediterranean each year, but its deep-blue waters host ... 1,000 alien species, including fish, crustaceans, and algae ... activities. In the open-access journal Frontiers in ... analyzed data from a new information system developed ... introduction of alien species has changed the native ...
(Date:9/30/2014)... most comprehensive assessment conducted by the Ocean Health ... of 100 in overall health. In addition, for ... and the 15 ocean regions beyond national jurisdiction ... a healthy climate, safeguarding biodiversity and providing sustainable ... of the index, a partnership led by scientists ...
Breaking Biology News(10 mins):Scientists wield plant viruses against deadly human disease 2Scientists wield plant viruses against deadly human disease 3Biodiversity in the Mediterranean is threatened by alien species 2Rating the planet's oceans 2Rating the planet's oceans 3
... release is available in Spanish . , Barcelona, ... been discovered that neutrophils exist in the spleen without there ... group on the Biology of B Cells of IMIM (Hospital ... Sinai in New York, has also made it possible to ...
... imaging technologies and their contrast agents chemicals used during ... exposure to radiation or heavy metals, which present potential health ... applied. In an effort to mitigate these drawbacks, new research ... an iron-based contrast agent so that it only interacts with ...
... Calif., December 23, 2011 John C. Reed, M.D., Ph.D., ... Institute (Sanford-Burnham), have been named as Fellows of the American ... AAAS Fellow is an honor bestowed upon AAAS members by ... announced today in the AAAS News & Notes section of ...
Cached Biology News:Discovered the existence of neutrophils in the spleen 2Penn engineers develop more effective MRI contrast agent for cancer detection 2Penn engineers develop more effective MRI contrast agent for cancer detection 3AAAS and Sanford-Burnham announce 2011 fellows 2
... is a derivative of Taq DNA polymerase. ... aquaticus DNA polymerase. Expressed from a gene ... Met236, bypassing the 5'-3' exonuclease domain of ... a highly active and even more heat-stable ...
... Neogens enzyme-linked immunosorbent assay (ELISA) test ... screening devices for the detection of drugs ... kits are intended for forensic use only. ... be confirmed by a quantitative method such ...
... protein ribonuclease inhibitor that noncovalently binds and inactivates ... seen with RNase 1, T1, T2, H, U1, ... placental ribonuclease inhibitor in that it has a ... release active RNase in the absence of DTT ...
...
Biology Products: