Navigation Links
NIH scientists show how anthrax bacteria impair immune response
Date:11/17/2010

WHAT: Researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have determined a key mechanism by which Bacillus anthracis bacteria initiate anthrax infection despite being greatly outnumbered by immune system scavenger cells. The finding, made by studying genetically modified mice, adds new detail to the picture of early-stage anthrax infection and supports efforts to develop vaccines and drugs that would block this part of the cycle.

To start an infection, anthrax bacteria release a toxin that binds to immune cells through two receptors, TEM8 and CMG2, found on the cell surface. The binding allows two additional bacterial toxins to enter the cells, setting off a chain of events that impairs their ability to ingest and kill the bacteria.

In the new research, NIAID investigators Stephen Leppla, Ph.D., Shihui Liu, M.D., Ph.D., and colleagues bred mice that lacked CMG2 receptors on two kinds of immune cells, neutrophils and macrophages. These usually are the first cells to arrive at the site of an anthrax infection, where they engulf the invading bacteria and try to prevent the spread of infection.

Mice without CMG2 receptors on these immune cells were completely resistant to infection by B. anthracis bacteria, experiencing only a temporary swelling at the site of infection, and fully clearing the infection within two weeks. In contrast, in normal mice, the level of anthrax bacteria increased rapidly in the 48 hours following infection, and all the mice died within six days.

The researchers concluded that B. anthracis uses CMG2 receptors to impair the scavenging action of neutrophils and macrophages during early infection, giving the bacteria time to multiply to levels sufficient to overwhelm the body's defenses. Developing drugs and vaccines that block B. anthracis from establishing early infection via binding to the CMG2 receptor, say the study a
'/>"/>

Contact: Anne A. Oplinger
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Clemson scientists put a (nano) spring in their step
2. City of Hope Helps KGI Launch New Management Training Program for Scientists
3. University of Pennsylvania scientists move optical computing closer to reality
4. Scientists grow nanonets able to snare added energy transfer
5. The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters
6. Scientists peel away the mystery behind golds catalytic prowess
7. SACHEM Launches 2-D HPLC e-Learning Program : New e-Learning Program Teaches Scientists How to Better Analyze and Prove Product Purity Through Greater Sensitivity and Precision in Identification of Trace Components
8. Vermillion and Stanford Scientists Receive Best Research Award From the PAD Coalition
9. Brewing better beer: Scientists determine the genomic origins of lager yeasts
10. Tengion Scientists Publish Positive Preclinical Findings With Neo-Organ Demonstrating Long-term Durability and Growth With Skeletal Maturation
11. CU scientists create worlds thinnest balloon -- just one atom thick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2015)... 2015 Australian prostate cancer technology company Minomic ... prize recognising ,outstanding, science that uses its patented antibody. ... a novel prostate cancer diagnostic test known as MiCheck® ... taking out the peer-reviewed Australian Museum Eureka Science Prize ... This prize is awarded for ground breaking research ...
(Date:9/2/2015)... Biovista Inc. freut sich, ... 2015 bekanntgeben zu können. Hierbei handelt es sich ... Biovista unterstützt mit seiner Möglichkeit der Analyse ... Krankheiten als denen, für die ein Medikament ursprünglich ... Team bei der Wylder Nation Foundation bei der ...
(Date:9/2/2015)... , ... September 02, 2015 , ... ... and life science research, today unveiled Genedata Screener ® version 13.0 at ... in-vitro screening brings to market a rich set of new capabilities. Screener now ...
(Date:9/1/2015)... YORK , Sept. 1, 2015 /PRNewswire-USNewswire/ ... of cancer death in American men. One ... cancer and 233,000 new cases are diagnosed annually. ... experts are using a powerful new technique, ... small and large cancer lesions, treating only the ...
Breaking Biology Technology:Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3Biovista sponsert die Forschung von Wylder Nation Foundation zum Thema Mangel an saurer Sphingomyelinase 2New Genedata Screener 13.0 with Support for High Throughput Flow Cytometry and DMPK Unveiled at ELRIG 2New Genedata Screener 13.0 with Support for High Throughput Flow Cytometry and DMPK Unveiled at ELRIG 3New Genedata Screener 13.0 with Support for High Throughput Flow Cytometry and DMPK Unveiled at ELRIG 4September Is Prostate Cancer Awareness Month 2September Is Prostate Cancer Awareness Month 3September Is Prostate Cancer Awareness Month 4
... of Longer-term Phase 2 Switching Study, ... a,biopharmaceutical company developing small-molecule, orally administered,pharmacological chaperones ... today that the Company will present positive ... Plicera(TM) (isofagomine tartrate) for Gaucher disease,at the ...
... In yet another twist on the strangeness of the ... Technology (NIST) and the University of Maryland-College Park have ... brittle in bulk form behave as ductile as gold ... of future nanomachines. , NIST scientists Pradeep Namboodiri and ...
... FRANCISCO, Calif., March 12 ,Exelixis, Inc. (Nasdaq: EXEL ... chief executive officer of Exelixis, will present at the,Cowen ... ET / 1:00 p.m.,PT on Monday, March 17, 2008. ... and corporate strategy., The presentation will be webcast ...
Cached Biology Technology:Amicus Therapeutics Presents Positive Data from Phase 2 Clinical Trial of Plicera(TM) for Gaucher Disease 2Amicus Therapeutics Presents Positive Data from Phase 2 Clinical Trial of Plicera(TM) for Gaucher Disease 3Amicus Therapeutics Presents Positive Data from Phase 2 Clinical Trial of Plicera(TM) for Gaucher Disease 4Nanomaterials show unexpected strength under stress 2
(Date:8/11/2015)... Today, ZUK announced its Android smartphone Z1, featuring FPC,s ... in 2015 that relate to sales of FPC1155 for this smartphone ... MSEK for 2015. Jörgen Lantto, CEO of FPC, comments: ... smartphone manufacturer in China and we are ... for Z1 , its ...
(Date:8/10/2015)... 10, 2015 The latest 364 page ... analysis of the global border security market . ... $16.4bn in 2015. Now: Border security is hard ... of the business critical issue you need to know about ... ,s objective analysis of how this will impact your company ...
(Date:8/6/2015)... Germany , August 6, 2015 ... (SMI) shows the world,s first Eye Tracking ... Epson,s Moverio BT-200 see-through head mounted display and on ... unprecedented quality and efficiency is brought to personalized visualization ... the first time, professionals and researchers can integrate gaze, ...
Breaking Biology News(10 mins):FPC's Touch Fingerprint Sensor FPC1155 in ZUK's Smartphone Z1 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 2Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 3Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 4Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 5Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 6Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 7Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 8Border Security Market Report 2015-2025 - Growth in Biometrics, ICT, Manned and Unmanned Vehicles, and Perimeter Surveillance 9SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3
... is the most lifeless spot on the face of the Earth, ... of NASA scientists there earlier this month. , The University of ... they'd built could detect life in that crusty, arid land, then ... on the planet Mars. , In a place that hadn't seen ...
... southern hemispheres are linked by a phenomenon by which the ... A research team from the Universitat Autònoma de Barcelona and ... ocean circulation in the southern hemisphere has, in the past, ... today in Science will enable more accurate forecasts to be ...
... compounds that act on specific cellular targets has just ... the precise effects a given compound will have on ... tool, drug developers can design compounds that will act ... responses free of unwanted side effects. , The research, ...
Cached Biology News:Life detection instrument passes key test on road to Mars 2Life detection instrument passes key test on road to Mars 3Climatologists discover deep-sea secret 2Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines 2
... System is ideal for developing single ... reagents. The Luminex 100 Instrument System ... version 1.7, the XY platform and ... $2000 in free Beadlyte products if ...
Peptide-affinity Purified Polyclonal Antibody to ICEBERG Peptide with sequence EEDPQLASKMGLH, from C Terminus of the protein sequence according to NP_067546...
A431 cells Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Madin-Darby bovine kidney (MDBK) cells Source: Cell Lysate Form: Ready to Use Application: Western Blotting Control...
Biology Products: