Navigation Links
NIH grant ratchets up ASU research in molecular motors
Date:5/31/2011

Empowered by a $1.2 million grant from the National Institutes of Health (NIH), Arizona State University scientist Wayne Frasch is deciphering how one of the world's smallest molecular motors works in living cells. In the process, he is also casting light on a physics puzzle that has perplexed scientists for more than 40 years.

Frasch, a professor in the School of Life Sciences, examines the Fo molecular motor, its mechanism of action and how it partners with the F1 motor as part of the FoF1 ATP synthase. At about 10 nanometers in diameter, each motor is 10,000 times smaller than the width of a piece of paper. In living things, Fo and F1 are attached by a common rotary axel that allows the two motors to work together and supply energy to cells in the form of adenosine triphosphate (ATP).

Research of nanoscale motors is not just complicated by size. Molecular motors operate via extremely small motions that occur on time scales that have been extraordinarily difficult to measure. The Fo molecular motor is also embedded in a living cell's lipid membrane, which is only two molecules thick. Adding to the experimental challenge is the fact that the molecular motors' rotational energy arises from the flow of protons, positively-charged atomic particles, across that membrane.

The Frasch lab is among only a few laboratories equipped to visualize how a single molecule of the Fo motor rotates. Frasch and his ASU College of Liberal Arts and Sciences colleagues have developed an experimental system that embeds the Fo motor in an artificial phospholipid bilayer laid down in nanodiscs, which help to stabilize the molecular complexes. Frasch's group then devised an imaging strategy, using gold nanorods attached to Fo to monitor the rotation of the single FoF1 molecules.

"Knowing more about these tiny, but extraordinarily efficient nearly 100 percent molecular motors offers an avenue to development new technologies, such as power sour
'/>"/>

Contact: Margaret Coulombe
margaret.coulombe@asu.edu
480-727-8934
Arizona State University
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. BioDrain Medical, Inc. Granted Canadian Patent for its Streamway® Surgical Fluid Management System
2. Cephalon Granted Temporary Restraining Order in AMRIX® Patent Litigation
3. FDA Grants Fast Track Designation to Bayers Investigational Compound Regorafenib for the Treatment of Gastrointestinal Stromal Tumors
4. LSU-AgCenter and Aquatic Energy Recommended for Clean Technology Grant
5. Larta Institute Receives Award for National Institutes of Health Commercialization Assistance Program at 2011 Acquisition, Grants, and Small Business Symposium
6. Adeonas Multiple Sclerosis Clinical Trial Receives $1,594,553 Grant
7. Eigen Receives Two Grant Awards from U.S. Department of Health & Human Services
8. Morphotek Receives Grant to Support Development of Therapeutic Antibodies against Biowarfare Agents
9. Beijing Chaoyang District Court Grants Investigation Letters Against Inverness Medical Beijing, A Subsidiary of Alere Inc.
10. Cord Blood America: Court Grants Motion to Dismiss at Lawsuit Aimed at Blocking Acquisition
11. Optimer Pharmaceuticals Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4)
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIH grant ratchets up ASU research in molecular motors
(Date:9/15/2014)... JOSE, Calif. , Sept. 15, 2014 /PRNewswire/ ... Proposals (RFP) for flexible, printed product demonstrators (demos) ... a two-stage RFP process with pre-proposals due on ... January 2015.  Funds for proposals ultimately selected are ... and have a significant cost share by the ...
(Date:9/15/2014)... downhill fast when a patient has sepsis, a life-threatening ... patient,s blood -- often too fast for antibiotics to ... and developed by a team at Harvard,s Wyss Institute ... doctors treat sepsis. , "Even with the best ... units at least 30 percent of the time," said ...
(Date:9/15/2014)... An interdisciplinary team of researchers led by Northeastern ... constructing precise inter-nanotube junctions and a variety of ... is facile and easily scalable, which will allow ... nanotube networks for use in applications ranging from ... everything from cars to sports equipment. , Their ...
(Date:9/15/2014)... , Sept. 15, 2014 Zymo ... viral transport solution for safe ambient temperature storage ... molecular testing. Importantly, the infectivity of agents in such ... maintaining the integrity of the viral nucleic acids ... the recent Ebola epidemic in West ...
Breaking Biology Technology:FlexTech Alliance Issues 2015 Request for Proposals in Flexible, Printed Electronics 2Blood-cleansing biospleen device developed for sepsis therapy 2Blood-cleansing biospleen device developed for sepsis therapy 3Blood-cleansing biospleen device developed for sepsis therapy 4Northeastern University Researchers Develop Novel Method for Working with Nanotubes 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 3
... Oncolytics Biotech Inc.,("Oncolytics") (TSX:ONC, NASDAQ:ONCY) announced that ... is scheduled to deliver a presentation on,Wednesday, ... Process for,the Oncolytic Agent REOLYSIN(R) (Human Reovirus)" ... Production Conference in Cologne, Germany. The,conference runs ...
... for controlling the magnetic properties of a commonly used ... research published recently in Advanced Materials. , Scientists have ... dye known as Metal Phthalocyanine, or MPc, with the ... still in its infancy, researchers claim that the ability ...
... ), a leader in the discovery and development of safe ... is scheduled to,present at the Bank of Montreal,s 2007 Focus ... and CFO of Bionovo, Inc., will,take place on Wednesday, December ... Hotel in New York City., To access a live ...
Cached Biology Technology:Oncolytics Biotech Inc. to Present at Annual Vaccine Production Conference 2Blue dye could hold the key to super processing power 2Blue dye could hold the key to super processing power 3
(Date:9/15/2014)... PULLMAN, Wash.Washington State University researchers have found "the most ... that can be used to transfer valuable genes ... the way for breeders to develop wheat varieties with ... a legion of genetic tools that can reduce crop ... hurdles and controversy of Genetically Modified Organisms, or GMOs., ...
(Date:9/15/2014)... years after it formed may have been surprisingly similar ... active crustal plates. , This alternate view of Earth,s ... new support from the first detailed comparison of zircon ... with those formed contemporaneously in Iceland, which has been ... , The study was conducted by a team of ...
(Date:9/15/2014)... published account where hippopotamuses are demonstrably shown swimming or ... But if they can,t swim, how did they reach ... models for the methods, patterns, and timing of the ... and Madagascar) may need to be reconsidered. , "Although ... mainland are not currently supported by positive geological evidence, ...
Breaking Biology News(10 mins):WSU researchers find 'most famous wheat gene' 2Early Earth less hellish than previously thought 2Early Earth less hellish than previously thought 3
... just hidden from view, a mystery atom in the ... hindered scientists, ability to study the enzyme fully. ... Serena DeBeer, Cornell assistant professor of chemistry and chemical ... spectroscopy and computational modeling to reveal carbon as the ...
... Nov. 17, 2011 Minntech Corporation has been named ... Sciences - Established Companies Category. Presented by the Minnesota ... and individuals who have played a significant role in ... futures of people living around the world. ...
... hand-weeding and/or herbicide application, controlling weeds is one of ... have made hand-weeding prohibitive as the sole method of ... less expensive, non-target herbicide loss can be as high ... the economic and environmental impact of weed problems, nursery ...
Cached Biology News:In an enzyme critical for life, X-ray emission cracks mystery atom 2Minntech Corporation Receives 2011 Tekne Award 2Minntech Corporation Receives 2011 Tekne Award 3Biodegradable mulches successfully control weeds in container-grown arborvitae 2
Human plasmacytoid dendritic cells, BDCA-4+, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Umbilical cord blood basophils, For immunohistochemistry (IHC)...
Human peripheral blood CD8+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Umbilical cord blood CD4+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood MNCs and T Cells...
Biology Products: