Navigation Links
NIH grant ratchets up ASU research in molecular motors
Date:5/31/2011

Empowered by a $1.2 million grant from the National Institutes of Health (NIH), Arizona State University scientist Wayne Frasch is deciphering how one of the world's smallest molecular motors works in living cells. In the process, he is also casting light on a physics puzzle that has perplexed scientists for more than 40 years.

Frasch, a professor in the School of Life Sciences, examines the Fo molecular motor, its mechanism of action and how it partners with the F1 motor as part of the FoF1 ATP synthase. At about 10 nanometers in diameter, each motor is 10,000 times smaller than the width of a piece of paper. In living things, Fo and F1 are attached by a common rotary axel that allows the two motors to work together and supply energy to cells in the form of adenosine triphosphate (ATP).

Research of nanoscale motors is not just complicated by size. Molecular motors operate via extremely small motions that occur on time scales that have been extraordinarily difficult to measure. The Fo molecular motor is also embedded in a living cell's lipid membrane, which is only two molecules thick. Adding to the experimental challenge is the fact that the molecular motors' rotational energy arises from the flow of protons, positively-charged atomic particles, across that membrane.

The Frasch lab is among only a few laboratories equipped to visualize how a single molecule of the Fo motor rotates. Frasch and his ASU College of Liberal Arts and Sciences colleagues have developed an experimental system that embeds the Fo motor in an artificial phospholipid bilayer laid down in nanodiscs, which help to stabilize the molecular complexes. Frasch's group then devised an imaging strategy, using gold nanorods attached to Fo to monitor the rotation of the single FoF1 molecules.

"Knowing more about these tiny, but extraordinarily efficient nearly 100 percent molecular motors offers an avenue to development new technologies, such as power sour
'/>"/>

Contact: Margaret Coulombe
margaret.coulombe@asu.edu
480-727-8934
Arizona State University
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. BioDrain Medical, Inc. Granted Canadian Patent for its Streamway® Surgical Fluid Management System
2. Cephalon Granted Temporary Restraining Order in AMRIX® Patent Litigation
3. FDA Grants Fast Track Designation to Bayers Investigational Compound Regorafenib for the Treatment of Gastrointestinal Stromal Tumors
4. LSU-AgCenter and Aquatic Energy Recommended for Clean Technology Grant
5. Larta Institute Receives Award for National Institutes of Health Commercialization Assistance Program at 2011 Acquisition, Grants, and Small Business Symposium
6. Adeonas Multiple Sclerosis Clinical Trial Receives $1,594,553 Grant
7. Eigen Receives Two Grant Awards from U.S. Department of Health & Human Services
8. Morphotek Receives Grant to Support Development of Therapeutic Antibodies against Biowarfare Agents
9. Beijing Chaoyang District Court Grants Investigation Letters Against Inverness Medical Beijing, A Subsidiary of Alere Inc.
10. Cord Blood America: Court Grants Motion to Dismiss at Lawsuit Aimed at Blocking Acquisition
11. Optimer Pharmaceuticals Reports Inducement Grants Under NASDAQ Listing Rule 5635(c)(4)
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
NIH grant ratchets up ASU research in molecular motors
(Date:4/24/2015)... N.J. , April 24, 2015  Navitas Life Sciences ... as Head of Clinical and Regulatory Services. Shalabh is ... been a co-founder and CEO of Kinapse, as well as ... Logo - http://photos.prnewswire.com/prnh/20150423/201261LOGO ... Jim Tizzard commented "I am delighted to welcome Shalabh ...
(Date:4/23/2015)... 23, 2015 The Thomas Brain ... conduct a groundbreaking pilot study to see if ... in as little as three to six months. ... and nutritional medicine—will aggressively target and simultaneously treat ... our aging brain. These include oxidative stress, neuroinflammation, ...
(Date:4/23/2015)... WuXi PharmaTech (Cayman) Inc. (NYSE: WX ... company serving the pharmaceutical, biotechnology and medical device industries, ... the United States , today announced ... quarter of 2015 after the New York Stock Exchange ... Thursday morning, May 14, 2015 Shanghai time). The earnings ...
(Date:4/23/2015)... April 23, 2015 Glemser ... the first EMC® Enterprise Content Division (ECD) Certified ... EMC Documentum® for Life Sciences Solution Suite ... knowledge and capabilities to provide life sciences companies ... , The EMC Documentum Solution Suite offers ...
Breaking Biology Technology:Shalabh Kumar Joins Navitas Life Sciences to Lead their Clinical and Regulatory Services Teams 2New Study Looks to Reverse Alzheimer’s Disease 2New Study Looks to Reverse Alzheimer’s Disease 3WuXi PharmaTech Schedules First-Quarter 2015 Earnings Release 2WuXi PharmaTech Schedules First-Quarter 2015 Earnings Release 3Glemser Earns Accreditation for Life Sciences Solution Suite 2
... Omeros Corporation (NASDAQ: OMER ), ... and commercializing products targeting inflammation, coagulopathies and disorders ... Gregory A. Demopulos, M.D., chairman and chief executive ... and Renshaw 13th Annual Healthcare Conference taking place ...
... , Gains US Patent Protection for Proprietary AAV Intellectual ... leader in the field of human gene therapy, today ... agreement with the US National Institutes of Health (NIH) ... therapy vectors for liver and brain indications. This agreement ...
... This September, during Prostate Cancer Awareness Month , ... method that may change the face of prostate ... and one Boston hospital, analyzed by the National Cancer Institute, ... Dr. David Samadi, Vice Chairman, Department of Urology, and ...
Cached Biology Technology:Amsterdam Molecular Therapeutics Licenses Additional Novel Gene Therapy Vectors from National Institutes of Health 2Amsterdam Molecular Therapeutics Licenses Additional Novel Gene Therapy Vectors from National Institutes of Health 3More Precise Prostate Cancer Screening on Horizon 2More Precise Prostate Cancer Screening on Horizon 3
(Date:4/13/2015)... , April 13, 2015 ... TechSci Research, "Global Biometrics Market Forecast & Opportunities, 2020", ... a CAGR of around 14% till 2020. The ... for large scale implementation and review of biometric ... launch of new products with greater efficiency, are ...
(Date:4/9/2015)... April 9, 2015 Synaptics Inc. (NASDAQ: SYNA ... today that it will report financial results for the ... 2015, after the close of market. The company will ... at 2:00 p.m. PT (5:00 p.m. ET), during which ... participate on the live call, analysts and investors should ...
(Date:4/2/2015)... 2, 2015 In the ... far outperforms the strongest competitors, showing outstanding performance ... the system is capable of a throughput of ... up to be ten times faster than most ... performance.      (Photo: http://photos.prnewswire.com/prnh/20150402/738673-a ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2Synaptics to Report Third Quarter Results on April 23 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... New research from The University of Western Ontario leads ... the Arctic Circle during the Pleistocene Epoch (approx. 150,000 ... three years later than modern day African elephants due ... nursing pattern could have contributed to the prehistoric elephant,s ...
... 21, 2010 Reportlinker.com announces that a new market ... Indian Biometric Market http://www.reportlinker.com/p0351944/Indian-Biometric-Market.html ... fastest emerging technology in the Indian Securities & Identification ... many conventional methods of Identity & Security checks like, ...
... Miscanthus x giganteus is the forerunner in the ... researchers believe "putting all their eggs in one basket" could ... recently reported the first natural occurrence in several decades of ... M. x giganteus is the only variety available, ...
Cached Biology News:Being good moms couldn't save the woolly mammoth 2New Miscanthus hybrid discovery in Japan could open doors for biofuel industry 2New Miscanthus hybrid discovery in Japan could open doors for biofuel industry 3
G-protein coupled purinergic receptor P2Y8...
This application changes sensitive keywords in an FCS file to remove patient information. It was contributed by Dr. David Miller....
Recognizes rat Taste Receptor 2 (TR2). The immunogen shows no significant sequence homology with TR1, gustducin or other pheromone receptors....
Rat monoclonal [HK5.3] to B7 RP1 (Biotin) ( Abpromise for all tested applications). entrezGeneID: 23308 SwissProtID: O75144...
Biology Products: