Navigation Links
NIH funds support UAB joint replacement research

BIRMINGHAM, Ala. Newly announced National Institutes of Health (NIH) funding will expand the reach of ongoing University of Alabama at Birmingham (UAB) research into a unique nanostructured coating to improve the performance and longevity of total joint replacement components. The broadened UAB research opportunity is funded by a four-year, $790,931 National Institutes of Health (NIH) grant through the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).

UAB's research, titled Bioengineering Research Partnership (BRP) in Total Joint Replacements, will explore next-generation technology to improve the service life of total joint replacements, which UAB researchers believe could dramatically cut the number of recurrent surgical procedures performed each year, said Yogesh Vohra, Ph.D., the BRP's principal investigator and director of the Center for Nanoscale Materials and Biointegration (CNMB) in the UAB School of Natural Sciences and Mathematics.

Vohra said the BRP opportunity will unite his UAB interdisciplinary research team with professionals at Smith and Nephew Inc., an international leader in the development of advanced medical devices. The company is known globally for its OXINIUMTM oxidized zirconium material for joint replacements.

"We have been researching our nanostructured multilayer diamond coating for a number of years inside our UAB facilities but there have been limitations to just how rigorous the testing could be," Vohra said. "The funding to partner with Smith and Nephew expands our research options because it offers us access to the company's resources and talent."

Among the benefits, Vohra said, the BRP allows access to Smith and Nephew's hip and knee simulators, which offer UAB researchers the most realistic testing conditions to date for their coating technology. Working with the multi-million dollar simulators should strongly indicate how well the team's nanostructured multilayer diamond coatings reduce the friction and wear on the metal components of orthopaedic devices, Vohra said. The team also will be able to examine the cellular and tissue responses to the technology and confirm that there is no toxicity effect from any wear debris that is generated.

"This partnership is central to advancing our research toward more reliable and efficient joint replacements," Vohra said. "We are gaining access to state-of-the-art testing equipment while benefitting from Smith and Nephew's experience as the industry leader in advanced bearing-surfaces for joint replacement implants."

The BRP also helps put the UAB coating technology on the fast track for commercialization, as it will foster the private industry relationship necessary to secure investment and production capacity, Vohra said.

The overall clinical impact of the BRP research is to drive down the number of recurrent surgical procedures for joint replacement recipients, who are living longer and pushing the longevity limits of their devices, Vohra said. The American Academy of Orthopaedic Surgeons reports that 15 to 20 percent of annual total joint replacement procedures are recurrent, or revision, surgeries. Vohra said the nanostructured diamond-coated devices should reduce the metal ion release to the surrounding tissues and perform better during long-term implantation in the human body, which could significantly cut the follow-up surgery rate.


Contact: Andrew Hayenga
University of Alabama at Birmingham

Related biology technology :

1. NeoStem Raises Additional Funds from Principals of Suzhou Erye Pharmaceuticals Company Ltd. and U.S. Institutional and Private Investors, Bringing the Total Recent Financings to Over $15 Million; Funds Will Support Expansion Activities in the United State
2. Printing New Organs: Foundation Funds Medical Technology That Replicates Human Tissue
3. Obama Budget Level Funds Career Technical Education
4. Immune Targeting Systems Completes Second Tranche of Series-A Funding Bringing Total Funds Raised to More Than GBP5m
5. LI-COR Biosciences Offers $1.75 Million in Matching Funds for Undergraduate Genomics Education
6. Hoana Medical and Hawaii Union Health and Welfare Trust Funds Partner to Fix Healthcare
7. NIH Funds $1M Research at Quest Product Development and University of Colorado for New Digitally-Controlled Endoscopes
8. Notice of Initial Distribution of Net Settlement Funds
9. NSF Funds New Entrepreneurship Program
10. NIH Funds Vaccine Research for Needle-free and Self-Administered Protection Against Pandemic Influenza
11. University of Florida Shands Cancer Center Selects OnCore(r) to Support its Collaborative Research Goals
Post Your Comments:
Related Image:
NIH funds support UAB joint replacement research
(Date:11/24/2015)... , ... November 24, 2015 , ... The United States ... of the 2016 USGA Green Section Award. Presented annually since 1961, the USGA Green ... or her work with turfgrass. , Clarke, of Iselin, N.J., is an ...
(Date:11/24/2015)... , Nov. 24, 2015 /CNW/ - iCo Therapeutics ... today reported financial results for the quarter ended ... expressed in Canadian dollars and presented under International ... United States ," said Andrew Rae ... advancements regarding iCo-008 are not only value enriching ...
(Date:11/24/2015)... 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ:  AEZS) (TSX: AEZ) ... of the Toronto Stock Exchange, confirms that as of ... corporate developments that would cause the recent movements in ... --> About Aeterna Zentaris Inc. ... Aeterna Zentaris is a specialty biopharmaceutical company engaged ...
(Date:11/24/2015)... ... ... This fall, global software solutions leader SAP and AdVenture Capital brought together dozens ... BIG ideas to improve health and wellness in their schools. , Now, the top ... of SAP's Teen Innovator, an all-expenses paid trip to Super Bowl 50, and an ...
Breaking Biology Technology:
(Date:11/16/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... announced expansion of its TDDI product portfolio with ... and display driver integration (TDDI) solutions designed to ... TDDI products add to the previously-announced TD4300 ... resolution), and TD4322 (FHD resolution) solutions. All four ...
(Date:11/11/2015)... Minn. , Nov. 11, 2015   MedNet Solutions ... entire spectrum of clinical research, is pleased to announce that ... in Clinical Trials (PCT) event, to be held November ... be able to view live demonstrations of iMedNet ... and learn how iMedNet has been able to ...
(Date:11/9/2015)... Nov. 9, 2015  Synaptics Inc. (NASDAQ: SYNA ... announced broader entry into the automotive market with a ... the pace of consumer electronics human interface innovation. Synaptics, ... ideal for the automotive industry and will be implemented ... Europe , Japan , ...
Breaking Biology News(10 mins):