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NIH collaborates with EPA to improve the safety testing of chemicals
Date:2/14/2008

al effort will explore the use of high-throughput screening assays in toxicology, NHGRIs Dr. Collins said. Such assays allow for the testing of thousands to hundreds of thousands of chemicals a day to determine their possible toxic effect. NCGC is part of a larger Molecular Libraries Imaging Program within the NIH Roadmap for Medical Research. It was designed to advance research on molecules from which most medicines marketed today are derived.

We now are seeing tools newly available to us for chemical genomics research deployed for greater refinement, speed and capacity in chemical toxicity screening, Dr. Collins said.

The experimental and computational expertise required to transform toxicology is an enormous undertaking and too great for any of our existing organizations to accomplish alone, said NTPs Dr. Bucher. This collaborative approach allows us to draw on our individual strengths and establishes a long-term, multiple U.S. federal agency commitment. NTP will contribute thousands of compounds for testing. NTPs animal toxicology expertise will be utilized, along with a large database of the chemicals effects on animals, with which the new cell-based data will be compared.

As our detailed research strategy continues to develop, we will welcome the participation of other federal partners, as well as interested public and private sector organizations, to make this vision of 21st century toxicology a reality said EPAs Dr. Gray. The EPAs engagement in this collaboration is part of its ToxCast programan initiative launched in 2007 to revolutionize the agency's chemical toxicity evaluation procedures. ToxCast will use advances in computers, genomics and cellular biology to speed up toxicity testing and enhance capacity to screen new compounds.


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Contact: Raymond MacDougall
macdougallr@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

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