Navigation Links
NIH collaborates with EPA to improve the safety testing of chemicals
Date:2/14/2008

oals, including: identification of toxicity pathways; selection of chemicals for testing; analysis and interpretation of data; and outreach to scientific and regulatory communities. The collective budget is yet to be determined.

The MOU and the plans articulated in the Science article provide a framework to implement the long-range vision outlined in the 2007 National Research Council (NRC) report, Toxicity Testing in the 21st Century: A Vision and a Strategy, which calls for a collaborative effort across the toxicology community to rely less on animal studies and more on in vitro tests using human cells and cellular components to identify chemicals with toxic effects. Importantly, the strategy calls for improvements in dose-response research, which will help predict toxicity at exposures that humans may encounter.

The collaborative research program is outlined in the jointly authored Science paper.

The co-authors Francis S. Collins, M.D., Ph.D., NHGRI director; George M. Gray, Ph.D., assistant administrator for EPAs Office of Research and Development which houses the NCCT; and John R. Bucher, Ph.D., NTP associate director describe the possibility of shifting from reliance on animal testing to biochemical- and cell-based assays, as well as those using lower organisms, such as zebrafish and roundworms.

Data collection to determine chemical toxicity currently relies heavily on whole-animal tests. The growing number of new chemicals, high testing costs and public unease with animal testing led to the search for alternate toxicology testing methods. Quantitative high-throughput screening (qHTS), developed at NCGC, increases the rate at which chemicals are tested, and profiles compounds over a wide range of concentrations. These qualities make the new qHTS technology ideal for toxicology testing, with the potential for advancing the goal of more accurate and timely public health decisions.

A central component of feder
'/>"/>

Contact: Raymond MacDougall
macdougallr@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. GeneGo Collaborates With The Netherlands Toxicogenomics Center on $100 Million Grant
2. NYU Medical Center Collaborates With Rosetta Genomics to Develop a microRNA-Based Diagnostic Test for Melanoma
3. New polymer could improve semiconductor manufacturing, packaging
4. China Biologic Products Gains Financial Support from Shandong Provincial Government on the Improvement of Production Facilities
5. Physicians Practice, Loma Linda Partner to Improve Patient Care in Southern California
6. Synthetech Earns National Recognition for Performance Improvement Program
7. Taxotere(R)-Based Chemotherapy Significantly Improved Overall Survival Compared With Standard Anthracycline-Based Chemotherapy in Early Stage Breast Cancer
8. Caliper Life Sciences Introduces Zephyr SPE Workstation to Improve Efficiency of Solid Phase Extraction
9. eHealth Initiative Foundation Launches Collaborative Research Effort to Improve Drug Safety
10. Diagnostic Turnaround Improved by 600% Through Interoperability
11. Improved wettability of carbon nanotubes opens the door to new possibilities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... to disease risks, the biological characteristics people care most ... for heightthe textbook example of a complex traitattributes like ... multiple genetic and environmental influences, making it challenging to ... geneticists typically mate two individuals that differ in key ... then study their descendents, looking for genes that tend ...
(Date:9/19/2014)... YORK, September 18, 2014 Scientists at NYU Langone ... dramatically the efficiency of the process for turning adult ... well-known compounds, including vitamin C. Using the new technique ... cells obtained from adult skin cells by more than ... technique is efficient and reliable, and thus should generally ...
(Date:9/19/2014)... that use light, rather than electricity, to move ... energy efficiency is a growing concern as chips, ... components of optical circuits light emitters, modulators, ... build. One promising light source for optical chips ... properties when deposited as a single, atom-thick layer. ...
(Date:9/19/2014)... San Jose, California (PRWEB) September 19, 2014 ... – Nanotechnology and its potential to revolutionize the ... government agencies, multinational corporations and small start-ups. The ... government funded research projects largely due to the ... capital investments. Government budgets earmarked for this evolving ...
Breaking Biology Technology:Want to link genes to complex traits? Start with more diversity 2NYU Langone scientists report reliable and highly efficient method for making stem cells 2NYU Langone scientists report reliable and highly efficient method for making stem cells 3Toward optical chips 2Toward optical chips 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4
... Fla. -- Engineers at Florida State Universitys National High Magnetic ... that could literally shed new light on nanoscience and semiconductor ... Helix -- is operational in 2010, researchers will have the ... not only down the bore, or center, of the magnet, ...
... N.J., Oct. 31 Amicus Therapeutics,(Nasdaq: ... molecule,orally-active pharmacological chaperones for the treatment of ... the third quarter of 2007.,On a reported ... Accepted,Accounting Principles (GAAP), Amicus announced a net ...
... Calif., Oct. 31 Align,Technology, Inc. (Nasdaq: ... of straightening teeth without wires or brackets, has ... for Silicon Valley, a,ranking of the fastest growing ... region by Deloitte & Touche USA LLP, one ...
Cached Biology Technology:Let there be light: new magnet design continues magnet lab's tradition of innovation 2Amicus Therapeutics Announces Third Quarter 2007 Financial Results 2Amicus Therapeutics Announces Third Quarter 2007 Financial Results 3Amicus Therapeutics Announces Third Quarter 2007 Financial Results 4Amicus Therapeutics Announces Third Quarter 2007 Financial Results 5Amicus Therapeutics Announces Third Quarter 2007 Financial Results 6Amicus Therapeutics Announces Third Quarter 2007 Financial Results 7Amicus Therapeutics Announces Third Quarter 2007 Financial Results 8Align Technology, Inc. Ranked 23rd in Deloitte's Technology Fast 50 Program for Silicon Valley Scientific & Medical Equipment, and Bio-Technology Companies 2Align Technology, Inc. Ranked 23rd in Deloitte's Technology Fast 50 Program for Silicon Valley Scientific & Medical Equipment, and Bio-Technology Companies 3
(Date:9/19/2014)... a newly discovered hadrosaur with a truly ... Rhinorex condrupus by paleontologists from North Carolina ... what is now Utah approximately 75 million years ... which translates roughly into "King Nose," was a ... hadrosaurs like Parasaurolophus and Edmontosaurus. Hadrosaurs are usually ...
(Date:9/19/2014)... A new resource unveiled today by researchers from ... College Dublin provides both experienced and aspiring researchers ... build, and operate robots made from soft, flexible ... printing, laser cutters, and other advances in manufacturing ... important field. Using principles drawn from conventional rigid ...
(Date:9/19/2014)... of Oklahoma biology professor will study the unique bioelectric ... could eventually benefit people,s health. The OU researcher ... energy required to produce the signals used to map ... signals at a rate of 500-600 discharges a second ... the electric fish are extreme, but necessary for survival. ...
Breaking Biology News(10 mins):New hadrosaur noses into spotlight 2Soft robotics 'toolkit' features everything a robot-maker needs 2
... Microbial fuel cells, chemical sensors for your iPhone, and ... batteries, safer nuclear power, and new crime scene investigation ... the science of materials, interfaces, and processing. Detailed press ... 60th International Symposium & Exhibition will take place Oct. ...
... The harmful effects of increasingly popular designer cannabis products ... but now a group of researchers is reporting progress ... published in the ACS journal Analytical Chemistry , ... physicians diagnose and treat the thousands of young adults ...
... This news release is available in French . ... Montreal and the Institut universitaire de gratrie de Montral examined ... without mild cognitive impairment (MCI) at the early stages of ... more cortical thinning and subcortical atrophy over time compared with ...
Cached Biology News:AVS science symposium in Long Beach Oct. 27 -- Nov. 2 2
... 8-iso PGE2 is one of several isoprostanes ... is a potent renal vasoconstrictor in the rat. ... with IC50 values of 0.5 and 5 µM, ... the rat at a concentration of 4 mg/kg/min, ...
... The Centra-CL5R multi-purpose centrifuge offers ... a large assortment of rotor options, ... of laboratory applications., Maximum Versatility , ... 21,000 xg) angle rotors or high-volume (4 ...
...
... The Turn & Cast submarine gel systems used gasketed ... the gel in the tank. Turn it back and ... For added convenience, each Turn & Cast tray is ... near the edge of the tray and one in ...
Biology Products: