Navigation Links
Muscular protein bond -- strongest yet found in nature
Date:7/20/2009

A research collaboration between Munich-based biophysicists and a structural biologist in Hamburg is helping to explain why our muscles, and those of other animals, don't simply fall apart under stress. Their findings may have implications for fields as diverse as medical research and nanotechnology.

The real strength of any skeletal muscle doesn't start with exercise; it comes ultimately from nanoscale biological building blocks. One key element is a bond involving titin, a giant among proteins. Titin is considered a molecular "ruler" along which the whole muscle structure is aligned, and it acts as an elastic spring when a muscle is stretched.

Titin plays a role in a wide variety of muscle functions, and these in turn hinge on the stability with which it is anchored in a structure called the sarcomeric Z-disk. Research published in 2006 showed this anchor to be a rare palindromic arrangement of proteins that is, it "reads" the same way forward and backward in which two titin molecules are connected by another muscle protein, telethonin. Simulations have pointed toward a network of tight hydrogen bonds linking titin and telethonin as a source of stability. But direct measurements that would further advance this investigation have been lacking, until today's publication of experimental results in the Proceedings of the National Academy of Sciences (PNAS). The authors are Prof. Matthias Rief and Morten Bertz, M.Sc., of the Technische Universitt Mnchen (TUM) who also are members of a Munich-based "excellence cluster" called the Center for Integrated Protein Science and Prof. Matthias Wilmanns of the European Molecular Biology Laboratory in Hamburg.

These first-ever measurements of mechanical stability in the titin-telethonin protein complex show it to be a highly "directed" bond, extremely strong but only along the lines of natural physiological stress. Thus even at the nanoscale, this complex is oriented to resist forces tha
'/>"/>

Contact: Patrick Regan
regan@tum.de
49-892-892-2743
Technische Universitaet Muenchen
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Insmed Announces Results of IPLEX(TM) Phase II Trial in Myotonic Muscular Dystrophy
2. PTC Therapeutics and Spinal Muscular Atrophy Foundation Announce $8.5 Million Small Molecule Development Collaboration
3. Assay Designs(TM), Inc. and the Spinal Muscular Atrophy Foundation Announce Collaboration To Accelerate the Discovery of New Therapeutics for Spinal Muscular Atrophy (SMA)
4. Palladian Muscular Skeletal Health (formerly Prism Health Networks) to Promote Collaborative, Expanded Practice Model at Major Insurance Conference in June
5. AMT Accesses Technology for Treatment of Duchenne Muscular Dystrophy
6. Families of Spinal Muscular Atrophy; University of California, Irvine Stem Cell Scientist; and California Stem Cell Announce Collaboration for Safety Studies for Stem Cell Therapy in Spinal Muscular Atrophy
7. Insmed Awarded $2.1 Million by Muscular Dystrophy Association
8. Caliper Life Sciences Introduces Staccato Protein Workstation for Automated Protein Sample Preparation & Analysis
9. CEM Wins Presidential Green Chemistry Challenge Award for the Sprint Rapid Protein Analyzer
10. First ASMS Hites Award for Outstanding Research Publication Presented to Prof. Alison Ashcroft for Her Use of Waters Synapt HDMS System to Explore Protein Complexes
11. Assay Designs(TM), Inc. Announces Release of First Available Product for Multiplex Analysis of Heat Shock Proteins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/5/2015)... Bi-Biomics today announced a discovery ... additive. The improvement in histological quality provided the ... in all daughter cells. , After processing with ... analyzed at 1000-1600x using light microscopy. Phylogenetic ... all daughter cells displayed predominant binary features --- ...
(Date:3/5/2015)... and TORONTO , March 5, ... a clinical-stage company developing new therapeutics and molecular diagnostics ... that William G. Rice , Ph.D., Chairman, President ... 27th Annual ROTH Conference on Tuesday, March 10 th ... Carlton, Laguna Niguel, CA. Dr. ...
(Date:3/5/2015)... DUBLIN , Mar. 05, 2015 Research and ... addition of the "Mature Biotech Outlook 2015: New ... to their offering. All biotech companies ... Celgene (CELG), in past year, have given a positive ... These companies have been able to select therapy/niche indication ...
(Date:3/5/2015)... e2b teknologies , a premier Sage ... Ohio, today announced a leading independent multi-specialty physician group ... to the latest version of Sage 100 ERP ... its kind in the region, the organization has an ... efficiency and data accessibility are paramount to their ongoing ...
Breaking Biology Technology:Aptose Biosciences to Present at the 27th Annual ROTH Conference 2Aptose Biosciences to Present at the 27th Annual ROTH Conference 3Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 2Mature Biotech Outlook 2015: New Therapy Ventures Pave the Way for Success 3Physician Group Practice Chooses e2b teknologies to Support Its Upgrade to Sage 100 ERP 2014 2
... Md., Feb. 15, 2011 United Therapeutics Corporation (Nasdaq: ... for the fourth quarter and year ended December 31, 2010. ... by the growth in our revenues," remarked Martine Rothblatt, ... addition, we are pleased to announce that we expect ...
... Reportlinker.com announces that a new market research report ... Pipeline Insight: Cancer Overview- Breast and Gynecological Cancers ... http://www.reportlinker.com/p0386436/Pipeline-Insight-Cancer-Overview--Breast-and-Gynecological-Cancers---Promising-agents-emerge-for-BRCA-positive-patients.html ... types covered in this report are set to ...
... is available in French . Scientists have ... two paintings by Vincent van Gogh and other artists of ... to understanding how to stop the bright yellow colours of ... brown shade, and fading over time. In the meantime, the ...
Cached Biology Technology:United Therapeutics Corporation Reports 2010 Fourth Quarter and Annual Financial Results 2United Therapeutics Corporation Reports 2010 Fourth Quarter and Annual Financial Results 3United Therapeutics Corporation Reports 2010 Fourth Quarter and Annual Financial Results 4United Therapeutics Corporation Reports 2010 Fourth Quarter and Annual Financial Results 5United Therapeutics Corporation Reports 2010 Fourth Quarter and Annual Financial Results 6United Therapeutics Corporation Reports 2010 Fourth Quarter and Annual Financial Results 7United Therapeutics Corporation Reports 2010 Fourth Quarter and Annual Financial Results 8United Therapeutics Corporation Reports 2010 Fourth Quarter and Annual Financial Results 9Reportlinker Adds Pipeline Insight: Cancer Overview- Breast and Gynecological Cancers - Promising agents emerge for BRCA positive patients 2X-rays show why van Gogh paintings lose their shine 2X-rays show why van Gogh paintings lose their shine 3X-rays show why van Gogh paintings lose their shine 4
(Date:3/3/2015)... LAKE FOREST, Calif. , March 3, ... ("Company"), the leading provider of advanced cryogenic ... serving markets including immunotherapies, stem cells, cell ... health, and reproductive medicine, today announced the ... Hutchinson Cancer Research Centers, ("Fred Hutch") ...
(Date:2/25/2015)... LITTLE ROCK, Ark. , Feb. 25, 2015 ... of software and billing in the Health and ... software as well as to MYiCLUBonline.  The latest ... MYiCLUBonline and the inclusion of cardless check-in via ... demonstrated for the first time through interactive displays ...
(Date:2/23/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ... authentication company focused on the growing mobile commerce market, ... for DISTRIBUTED VOICE DIRECTED PAYMENT METHOD AND ... new groundbreaking payment method. Payment accounts may be selected ... be accessed if both the speech (the word associated ...
Breaking Biology News(10 mins):Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 2Cryoport, Inc. Expands Support of Fred Hutchinson Cancer Research Center's Clinical Research Division 3ABC Financial Unveils New Software Enhancements 2ABC Financial Unveils New Software Enhancements 3NXT-ID Patents Voice Directed Payments 2NXT-ID Patents Voice Directed Payments 3
... are essential in the fight against breast cancer. ... system for investigation of physiological and pathological processes ... that occurs during puberty and the alveogenesis processes ... in many tissues during embryogenesis and are also ...
... in a wide variety of cells and tissues, including ... can enter the cytoplasm from the extracellular environment or ... enzymes, other signaling molecules, transcription factors, and cytoskeletal components. ... "Calcium Signaling" explores the channels and pumps that transport ...
... For one species of seabird in the Galpagos, the child abuse ... The new study of Nazca boobies by Wake Forest University ... who are abused when they are young often grow up to ... the ornithology journal, The Auk . "We were ...
Cached Biology News:Child abuse in birds: Study documents 'cycle of violence' in nature 2
The Lambda Control Kit contains lambda DNA and two 25mer primers, which can be used to amplify a 500bp fragment. The lambda DNA is purified by CsCl gradient centrifugation and organic extraction foll...
... Klein Taq is a derivative of Taq ... truncated Thermus aquaticus DNA polymerase. Expressed from ... initiates at Met236, bypassing the 5'-3' exonuclease ... enzyme reveals a highly active and even ...
Homo sapiens similar to Cytosolic acyl coenzyme A thioester hydrolase Antigen: Peptide...
96 Well Base Plate...
Biology Products: