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Multiple Vimpat(R) (lacosamide) Studies Presented at American Epilepsy Society Annual Meeting
Date:12/8/2008

t(R) appeared to provide a similar magnitude of seizure reduction versus placebo regardless of which AED was included as part of the patients' baseline treatment regimen, which included one to three concomitant AEDs:

    -- Carbamazepine (36.5 percent seizure frequency reduction with Vimpat(R)
       400 mg/day vs. 21.7 percent with placebo)
    -- Lamotrigine (33.3 percent vs. 18.3 percent)
    -- Levetiracetam (37.6 percent vs. 17.6 percent)
    -- Valproate (45.3 percent vs. 21.3 percent)
    -- Topiramate (41.4 percent vs. 28.5 percent)
    -- Oxcarbazepine (27.2 percent vs. 12.5 percent)

Similar results were seen for responder rates (patients with 50 percent or greater reduction in seizure frequency):

    -- Carbamazepine (37.4 percent responder rate with Vimpat(R) 400 mg/day
       vs. 26.4 percent placebo)
    -- Lamotrigine (34.2 percent vs. 19.0 percent)
    -- Levetiracetam (43.4 percent vs. 19.4 percent)
    -- Valproate (47.5 percent vs. 26.9 percent)
    -- Topiramate (41.9 percent vs. 25.6 percent)
    -- Oxcarbazepine (29.7 percent vs. 17.6 percent)

Poster Session 3, December 8, 2008, 8:00 - 9:00 am (Poster 3.246)

William Rosenfeld, MD, David Rudd, PharmD, David Hebert, PhD, Pamela Doty, PhD

The Comprehensive Epilepsy Care Center for Children and Adults, St. Louis, Missouri

Schwarz Biosciences Inc. (a member of the UCB Group), Raleigh, NC, USA

Safety and Tolerability of Lacosamide: A Summary of Adverse Events in Epilepsy Clinical Trials

This pooled analysis clinical trial safety data showed Vimpat(R) to be generally well-tolerated, although 85 percent of trial participants were already taking two to three concomitant AEDs upon trial entry:

-- The most frequently reported individual treatment emergent adverse events (TEAE) occurring in greater than or equal to 10 percent of the Vimpat(
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SOURCE UCB
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