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Multiple Types of Heart Attacks Reduced by Prasugrel in TRITON-TIMI 38 Trial
Date:5/21/2009

015).
  • The incidence of PCI-related heart attacks (Type 4) was 4.8 percent in prasugrel patients compared with 6.4 percent in clopidogrel patients (p=0.0002).
  • The majority of spontaneous heart attacks occurred after 30 days of treatment, and the risk of non-procedural heart attack during maintenance dosing through the entire 15 months of the study was 2.3 percent in patients taking prasugrel versus 3.1 percent in patients taking clopidogrel (p=0.0069).
  • Treatment with prasugrel reduced new and recurrent STEMI heart attacks, a high-risk form of heart attack (1.0 percent vs. 2.1 percent, p<0.0001), and NSTEMI heart attacks (6.5 percent vs. 7.9 percent, p=0.0024) compared with clopidogrel.
  • In the TRITON-TIMI 38 trial, there was an increased risk of major bleeding with prasugrel by 32 percent compared with clopidogrel (2.4 percent vs. 1.8 percent), which included life-threatening and fatal bleeding.(4)

  • About TRITON-TIMI 38

    The main TRITON-TIMI 38 clinical trial, previously published in the New England Journal of Medicine in November 2007 (Vol. 357 No.20), compared prasugrel with clopidogrel in patients with ACS undergoing PCI. In the primary analysis of the study, prasugrel reduced the risk of the combined endpoint of cardiovascular death, heart attack, or stroke by 19 percent (9.9 percent versus 12.1 percent), with an increased risk of major bleeding by 32 percent compared with clopidogrel (2.4 percent vs. 1.8 percent), which included life-threatening and fatal bleeding.(5)

    About Acute Coronary Syndromes

    Acute coronary syndromes (ACS), which includes heart attack and unstable angina (chest pain), affects more than 1.4 million people in the United States annually.(6) Coronary heart disease, which can result in ACS, is the single most common cause of death in the European Union, accounting for more than 74
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    SOURCE Eli Lilly and Company
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