Navigation Links
Multinational deCODE Study Identifies New Link Between Inflammation and Heart Attack
Date:2/9/2009

REYKJAVIK, Iceland, February 9 /PRNewswire-FirstCall/ -- In a paper published today, scientists at deCODE genetics (Nasdaq: DCGN) and academic colleagues from four continents present a novel insight into the connection between inflammation and heart disease. Through a genome-wide search in some 10,000 Icelanders, the deCODE team discovered several common single-letter variations in the sequence of the human genome (SNPs) that increase levels of eosinophils in the bloodstream. These are a type of white blood cell that fights parasite infection and mediates inflammation. One of these SNPs, located on chromsome 12q24, was then shown to confer increased risk of heart attack through analysis of the genomes of more than 46,000 patients and controls from Iceland, New Zealand, Italy, and the United States. Given the established role of eosinophils in asthma, the deCODE team also analyzed the eosinophil SNPs in more than 50,000 asthmatics and healthy control subjects from the countries above as well as from Germany, Sweden, Australia, and South Korea. A SNP on chromosome 2q12 was associated with increased risk of asthma, and three other SNPs were associated with risk of atopic asthma.

"This is a great example of how our population data and approach enable us to examine complex questions from multiple vantage points. There is broad interest in the connection between inflammation and cardiovascular disease, and our own discoveries on chromosome 9p21 and in the leukotriene pathway have helped to drive this interest. And in today's work, we started by identifying genetic variants involved in a known inflammatory process and then went on to demonstrate that some of those variants were also risk factors for both heart attack and asthma. These discoveries may be used both in drug discovery and to build out our tools for DNA-based risk assess
'/>"/>

SOURCE deCODE genetics Inc
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. YM BIOSCIENCES NIMOTUZUMAB SELECTED FOR MULTINATIONAL PHASE III TRIAL BY NATIONAL CANCER CENTRE OF SINGAPORE
2. Lorus Therapeutics Announces Exclusive Multinational License Agreement with Zoticon Bioventures for Virulizin(R)
3. The LANCET Published ENDORSE, the Largest Multinational Study Showing That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE Prophylaxis
4. deCODE Announces Transfer of the Listing of its Common Stock from Nasdaq Global Market to Nasdaq Capital Market
5. deCODE Discovers First Genetic Variant Conferring Increased Risk of Essential Tremor
6. deCODE Sells Auction Rate Securities
7. Introducing deCODEme Cardio(TM) and deCODEme Cancer(TM)
8. deCODE Discovers Common Genetic Variations Contributing to Low Bone Mineral Density and Risk of Osteoporosis
9. deCODE to Integrate New Genetic Risk Factor for Type 2 Diabetes Into Its deCODEme(TM) Personal Genome Scan Service
10. Major Independent Study Underscores Utility of deCODE MI(TM) for Better Predicting Risk of Heart Attack, Informing Statin Therapy
11. deCODE Study Expands Clinical Utility of deCODE AF(TM) for Improving the Diagnosis of Atrial Fibrillation and Preventing Stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/29/2015)... ... June 29, 2015 , ... ... Under the terms of the agreement, MediVet will acquire the rights to a ... MB-007 is currently in pre-clinical development as a potential next-generation treatment for various ...
(Date:6/29/2015)... ... June 29, 2015 , ... The global microfluidics market ... forecast period (2015 to 2020). The market is mainly driven by the rising ... for R&D. However, lack of adequate healthcare and research infrastructure in emerging markets, ...
(Date:6/29/2015)... DIEGO , June 29, 2015 BioNano ... group of top research institutes, announced today that a ... Mount Sinai resulted in the creation of the first ... complementary single DNA molecule methods for sequencing and genome ... , provided the comprehensive analysis of the contiguous diploid ...
(Date:6/29/2015)... 2015  AACC, a global scientific and medical ... medicine, is pleased to announce that the impact ... has increased to 7.9 in the 2014 Thomson ... Clinical Chemistry in the top 3% of ... of the research it publishes on laboratory medicine ...
Breaking Biology Technology:MediVet Biologics Acquires Exclusive Patent License from Kansas State University 2MediVet Biologics Acquires Exclusive Patent License from Kansas State University 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 4Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 5BioNano Mapping Technology Achieves Most Contiguous Clone-free Human Genome Assembly to Date 2BioNano Mapping Technology Achieves Most Contiguous Clone-free Human Genome Assembly to Date 3AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 2AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 3
... , , , Mark Churchill and Mark Harrison, Thermo Finnigan, ... , , , Bioanalytical Method ... can be acquired using , a Thermo Finnigan TSQ Quantum mass spectrometer, ... , , , , , , ...
... , , , , , , , ... , , , , Ion ... be acquired using , a Thermo Finnigan LCQ Advantage, LCQ Deca XP, and Deca XP ... , , Introduction , , , , ...
... , , , Anna M. ... Diseases, Brigham and Womens Hospital, Harvard , Medical School, Boston, ... , Genetic manipulations using neuronal cells are notoriously , ... to primary neuronal cultures is of critical importance for RNA interference , ...
Cached Biology Technology:Bioanalytical Method Intraday Validation for the Quantitation of Paroxetine , in Bovine Plasma using the TSQ Quantum Mass Spectrometer 2Bioanalytical Method Intraday Validation for the Quantitation of Paroxetine , in Bovine Plasma using the TSQ Quantum Mass Spectrometer 3Bioanalytical Method Intraday Validation for the Quantitation of Paroxetine , in Bovine Plasma using the TSQ Quantum Mass Spectrometer 4Bioanalytical Method Intraday Validation for the Quantitation of Paroxetine , in Bovine Plasma using the TSQ Quantum Mass Spectrometer 5Bioanalytical Method Intraday Validation for the Quantitation of Paroxetine , in Bovine Plasma using the TSQ Quantum Mass Spectrometer 6Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep , Technology 2Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep , Technology 3Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep , Technology 4Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep , Technology 5Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep , Technology 6Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep , Technology 7Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep , Technology 8Efficient RNAi-mediated gene silencing in neuronal cells using QIAGEN , siRNA and TransMessenger Transfection Reagent* 2Efficient RNAi-mediated gene silencing in neuronal cells using QIAGEN , siRNA and TransMessenger Transfection Reagent* 3Efficient RNAi-mediated gene silencing in neuronal cells using QIAGEN , siRNA and TransMessenger Transfection Reagent* 4Efficient RNAi-mediated gene silencing in neuronal cells using QIAGEN , siRNA and TransMessenger Transfection Reagent* 5
(Date:6/29/2015)... Research and Markets( http://www.researchandmarkets.com/research/zj7h4f/latin_america ) has ... Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Biomedical Sensors market is estimated at $0.65 billion by ... 2014-2020 The near future will bring Biomedical ... each individual. These sensors can be set to trigger ...
(Date:6/26/2015)... , June 26, 2015 ATL Technology, LLC, ... devices with specialties in single use solutions, headquartered in ... MedConx, Inc. (a California corporation with ... San Jose, Costa Rica ). ... Costa Rica with ATL Technology,s existing facility in ...
(Date:6/25/2015)... 25, 2015 According to ... (Swipe & Area), Technology, Material (Optical Prism, Piezoelectric, ... Security & Others) & Geography - Global Forecast ... said market is expected to reach $14,500.07 Million ... Browse 76 market Tables and 109 ...
Breaking Biology News(10 mins):Latin America Biomedical Sensors Market Report 2015-2020 2ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 2Fingerprint Sensors Market Worth $14,500.07 Million by 2020 3Fingerprint Sensors Market Worth $14,500.07 Million by 2020 4
... estimated 300,000 people in North America are afflicted with ... motor control. Patients with generalized dystonia grapple with involuntary ... in awkward, sometimes painful postures. Although cognition, intelligence and ... a devastating impact on quality of life, as its ...
... today the launch of a new brain atlas resource ... online to accelerate brain research around the globe. The ... the Allen Institute,s mapping efforts beyond its historical focus ... enhancements to the Allen Mouse Brain Atlas, the Allen ...
... Researchers can predict which children are most likely to become ... to a recent University of Montreal study published in the ... is extremely hard to change and is also influenced by ... hope these findings will help improve the social and medical ...
Cached Biology News:University Hospitals Case Medical Center unlocks mystery of dystonia with advanced imaging 2University Hospitals Case Medical Center unlocks mystery of dystonia with advanced imaging 3Allen Institute for Brain Science launches new atlas, adds new data and tools to others 2Allen Institute for Brain Science launches new atlas, adds new data and tools to others 3Future obesity may be predicted at 3.5 years of age 2
Polypropylene test tube racks, used in Thermo Forma's line of Test Tube Rack holders...
...
BD FastImmune EDTA Solution. Applications: Flow Cytometry Storage Temperature: Refrigerate(2 to 8C)...
Autoclavable, variable volumefitted w./ an anti-drip safety valve; borosilicate glass barrelprotected with transparentpolypropylene sleeve; spring-lock cursor design ensuresfine adjustment for exact ...
Biology Products: