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Mpex Pharmaceuticals Announces Positive Phase 2b Clinical Trial Results with Aeroquin(R) (MP-376) Treatment in Cystic Fibrosis Patients
Date:9/10/2009

e lungs allows for the rapid delivery of high concentrations of active drug directly to the site of infection, while minimizing systemic exposure. In addition to the trial described above in CF, Mpex is also conducting a large Phase 2 study in COPD that is now fully enrolled, with results expected to be available in the first half of 2010.

About Mpex Pharmaceuticals

Mpex Pharmaceuticals is a clinical stage biopharmaceutical company whose mission is to develop important new therapies to combat the growing issue of antibiotic resistance. The company's internal development pipeline focuses on combining proprietary formulations, PK/PD strategies and novel potentiating agents with proven antibiotics to overcome or directly inhibit the molecular mechanisms in bacteria responsible for antibiotic resistance. Mpex's most advanced product candidate, Aeroquin((R)) (MP-376), is a proprietary aerosol formulation of levofloxacin that is being developed clinically as a maintenance therapy for patients with CF or COPD. The company has also built a separate discovery and development platform and intellectual property estate around inhibitors of multi-drug resistant (MDR) efflux pumps (EPIs) found in many gram-negative bacterial pathogens. Bacterial efflux of antibiotics is a leading source of multi-drug resistance, particularly in gram-negative organisms. Mpex compounds have been shown in both in vitro and in vivo studies to overcome efflux-based resistance to multiple classes of antibiotics. Mpex has established a collaboration with GlaxoSmithKline focused on developing multiple drug candidates utilizing Mpex's EPI technology. Company website: www.mpexpharma.com.

About the Investigational eFlow Nebulizer System and PARI Pharma

Aeroquin (MP-376) is delivered via an Investigational eFlow Ne
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SOURCE Mpex Pharmaceuticals, Inc.
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