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'Move to AMITIZA' Advertising Campaign Underscores the Power of Not Letting Chronic Constipation Slow People Down
Date:11/6/2007

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Constipation, one of the most common digestive complaints in the U.S., affects up to 42 million adults, and is more prevalent in women than men. Based on a retrospective analysis, it is estimated that 12 million can be characterized as suffering from Chronic Idiopathic Constipation. Chronic Idiopathic Constipation is chronic constipation with no known cause. Older adults age 65 years and older are especially susceptible to constipation.

AMITIZA, developed by Sucampo Pharmaceuticals, is the first and only chloride channel activator for the treatment of Chronic Idiopathic Constipation in adults, regardless of age or gender. AMITIZA has a unique mechanism of action that may provide predictable relief to help people with Chronic Idiopathic Constipation.

For additional background about AMITIZA and Chronic Idiopathic Constipation, please log onto http://www.amitizapresskit.com.

About AMITIZA(R) (lubiprostone) 24 mcg BID for Chronic Idiopathic Constipation

AMITIZA(R) (lubiprostone) is indicated for the treatment of Chronic Idiopathic Constipation in adults.

AMITIZA is contraindicated in patients with known mechanical gastrointestinal obstruction. Patients with symptoms suggestive of mechanical gastrointestinal obstruction should be thoroughly evaluated by the treating physician to confirm the absence of such an obstruction prior to initiating AMITIZA treatment.

The safety of AMITIZA in pregnancy has not been evaluated in humans. In guinea pigs, lubiprostone has been shown to have the potential to cause fetal loss. AMITIZA should be used during pregnancy only if the benefit justifies the potential risk to the fetus. Women who could become pregnant should have a negative pregnancy test prior to beginning therapy with AMITIZA and should be capable of complying with effective contraceptive measures.

Patients taking AMITIZA may experience nausea. If this occurs, concomi
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SOURCE Takeda Pharmaceuticals North America, Inc. and Sucampo
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