Navigation Links
Mount Sinai leads program of excellence in nanotechnology with $16.5 million grant

Mount Sinai School of Medicine received a contract for almost $16.5 million from The National Institutes of Health (NIH) and the National Heart and Lung Institute (NHLBI) through the Program of Excellence in Nanotechnology (PEN). The contract is one of four issued nationally to develop multidisciplinary research Centers with the goal of developing nanotechnology tools for diagnosing and treating heart, lung and blood diseases. As co-principal investigator, Zahi A. Fayad, PhD, Professor of Radiology and Medicine and the Director of the Translational and Molecular Imaging Institute at Mount Sinai School of Medicine leads a team of world-renowned experts in the fields of cardiology, imaging, and bioengineering. He is joined by the center's other co-principal investigator Robert S. Langer, ScD, Massachusetts Institute of Technology, for this highly collaborative program aimed at utilizing nanotechnology to better prevent and treat cardiovascular disease.

As a leading authority in cardiovascular medicine and imaging, Mount Sinai plans to organize a Center that will develop state-of-the-art translational nanoparticle technologies to help treat and prevent atherosclerosis, heart attack, and heart failure. During the term of the five-year contract, the investigators at Mount Sinai and the other participating institutions are pursuing a three-pronged approach to the problem of cardiac disease. Investigators will explore minimally invasive nanotechnology-based advances to regenerate tissue damaged after heart attack. They will develop nanotherapies to repair defective inflammation resulting from atherosclerosis with a focus on "theranostics," or the use of nanotechnology to allow diagnostic therapy in atherosclerosis.

"There is enormous potential in the use of nanotechnology to treat cardiovascular disease, but it has remained largely unexplored," said Dr. Fayad. "Through this research, we hope to show that nanotherapies may have unprecedented benefits in preventing the progression of heart disease and improve the safety and efficacy of existing treatments."

In addition to the pioneering research aims of the PEN Center at Mount Sinai, the Center will institute a unique training program focused on developing translational nanomedical tools for diagnostic imaging and minimally invasive treatment of cardiovascular disease. Furthering Mount Sinai's ongoing commitment to translational research, the program will stress the importance of bringing the discoveries made as a result of the contract to the patient care setting.

"We are honored to have been selected as one of the primary investigation sites for the PEN program," said Dennis S. Charney, MD, Anne and Joel Ehrenkranz Dean of Mount Sinai School of Medicine and Executive Vice President for Academic Affairs at The Mount Sinai Medical Center. "The goals for this program embody Mount Sinai's unwavering commitment to translational research, and will open doors for our world-renowned physician-scientists to make significant advances in preventing and treating cardiovascular disease."

In addition to Dr. Fayad, the Mount Sinai project leaders are Valentin Fuster, MD, PhD, Director of Mount Sinai Heart, the Zena and Michael A. Wiener Cardiovascular Institute and the Marie-Josee and Henry R. Kravis Center for Cardiovascular Health; Roger Hajjar, MD, Research Director of the Wiener Family Cardiovascular Research Laboratories and the Arthur & Janet Ross Professor of Cardiology, Medicine, and Gene and Cell Medicine; and Martin Schwartz, PhD, Assistant Professor of Cardiology and Medicine. Other Mount Sinai investigators participating in the program are Willem Mulder, PhD, David Cormode, PhD, Kevin Costa, PhD, and Hina Chaudhry, MD. The other institutions involved in this grant are New York University, Columbia University, Brigham and Women's Hospital, and the Massachusetts Institute of Technology.

"Cardiovascular disease impacts millions of people, and costs billions of dollars each year in the United States alone," said Dr. Fuster. "Mount Sinai Heart has made important discoveries over the years to help reduce this impact, but much more can be done. This program will allow us to pave the way for new therapeutic and diagnostic approaches using nanotechnology to help end the burden of cardiovascular disease."

"We are thrilled about this wonderful and important opportunity and the potential that it brings to improve the diagnosis and treatment of cardiovascular disease, and commend the NHLBI for supporting this translational program," said Dr. Fayad.


Contact: Mount Sinai Press Office
The Mount Sinai Hospital / Mount Sinai School of Medicine

Related biology technology :

1. In-Room Computers and Wall-Mounted Proximity Systems Computer WorkStations Deliver Increased Efficiency; Improved Patient Care
2. Simbionix Raises Largest Amount in Companys History in Venture Capital to Accelerate Growth
3. AlloSource Distributes Record Amount of Tissue in 2008
4. Proximity Systems LAN Based Electronic Lock Management System Offers Increased Security, Efficiency and Reporting Capability for Wall-Mounted WorkStations
5. ViroPharma Improves Financial Position Through Repurchase of $45 Million Principal Amount of Senior Convertible Notes
6. New Generation Biofuels Signs Sales Contract with Catoctin Mountain Growers to Supply up to 370,000 gallons of Renewable Biofuel
7. Biologist discovers pink-winged moth in Chiricahua Mountains
8. TransTech Services Partners, Inc. Shareholders Approve Plan of Liquidation; Company To Distribute Amounts in Trust
9. Onyx Pharmaceuticals Announces Pricing of Concurrent Offerings of Four Million Shares of Common Stock and $200 Million Principal Amount of Convertible Senior Notes
10. Surface Mount Solutions Launches New Website
11. Amount of gene surplus determines severity of mental retardation in males
Post Your Comments:
(Date:11/24/2015)... , Nov. 24, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) today announced ... 29, 2015 at 11:00 a.m. Israel time, at ... 98 Yigal Allon Street, 36 th Floor, Tel Aviv, ... Eric Paneth and Izhak Tamir to the Board of ... as external directors; , approval of an amendment to certain terms ...
(Date:11/24/2015)... Schlieren, Switzerland (PRWEB) , ... November 24, 2015 , ... ... more organotypic 3D cell culture models, has promoted Melanie Aregger to serve as Chief ... Manager, Ms. Aregger served on the management team and was promoted to ...
(Date:11/24/2015)... Va. , Nov. 24, 2015 ... focused on discovering drugs for metabolic disorders, announced ... to its Board of Directors (BOD). Mr. ... officer of Human Genome Sciences (HGS), and also ... Organization. Jim Powers , Chairman and ...
(Date:11/24/2015)... YORK , Nov. 24, 2015 According to ... than in 2005. This is something that many doctors, scientists, ... time. One questions remains: with fewer PSA tests being done, ... ? Dr. David Samadi, "Despite the ... the disease remains the second leading cancer cause of death ...
Breaking Biology Technology:
(Date:11/10/2015)... YORK , Nov. 10, 2015 ... to behavioral biometrics that helps to identify and ... fraud. Signature is considered as the secure and ... the identification of a particular individual because each ... more accurate results especially when dynamic signature of ...
(Date:10/29/2015)... 29, 2015   MedNet Solutions , an innovative ... of clinical research, is pleased to announce that it ... (MHTA) as one of only three finalists for a ... Small and Growing" category. The Tekne Awards honor ... superior technology innovation and leadership. iMedNet™ ...
(Date:10/29/2015)... OXFORD, Connecticut , October 29, 2015 /PRNewswire/ ... "Company"), a biometric authentication company focused on the ... Wocket® smart wallet announces that StackCommerce, a leading ... will be featuring the Wocket® smart wallet on ... NXTD ) ("NXT-ID" or the "Company"), a ...
Breaking Biology News(10 mins):