Navigation Links
Mother’s Workplace Exposures During Pregnancy Cause Risk of Cleft Lip in Children
Date:4/18/2013

Lawrence, KS (PRWEB) April 18, 2013

Cleft Palate-Craniofacial Journal – The first study in human subjects has shown what studies with mice had already found—a mother’s exposure to polycyclic aromatic hydrocarbons is associated with a greater risk of her child having a cleft lip. Workplace exposure, primarily through inhaling the smoke of burning substances, carries this significant risk.

The case-control study, presented in Cleft Palate-Craniofacial Journal, included 2,989 control subjects, 805 cases of cleft lip with or without cleft palate, and 439 cases of cleft palate alone. It used data over a five-year period from the National Birth Defects Prevention Study.

The burning of coal, tobacco, and other substances creates polycyclic aromatic hydrocarbons. Occupations involving coke ovens, coal tar use, iron and steel works, carbon electrode production, and asphalt manufacturing are likely sources of exposure. Restaurants are another, more commonplace, source of exposure. Cigarette smoke, even secondhand, has already been established as a major source of exposure, showing a moderate association with clefts in earlier studies.

Mothers in this study participated in a computer-assisted telephone interview. Questions included maternal illnesses, medication use, pregnancy history, diet, and alcohol and tobacco use.

Additionally, the subjects supplied information about the jobs they held during preconception and pregnancy. Industrial hygienists assessed the occupational exposure these women experienced. The workplace exposure considered was limited to a period between one month prior to conception and three months after conception.

Those determined to be occupationally exposed to polycyclic aromatic hydrocarbons represented 3.5 percent of the control cases, 5.8 percent of the cleft lip cases, and 4.6 percent of the cleft palate cases. This study established a significant connection between maternal exposure to polycyclic aromatic hydrocarbons and the development of cleft lip or cleft lip and palate in the child. The association was not statistically significant for cleft palate alone, however.

Full text of the article, “Maternal Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Risk of Oral Cleft-Affected Pregnancies,” Cleft Palate-Craniofacial Journal, Vol. 50, No. 3, May 2013, is available at http://www.cpcjournal.org/doi/full/10.1597/12-104.

###

About Cleft Palate-Craniofacial Journal
The official publication of the American Cleft Palate-Craniofacial Association (ACPA), the Cleft Palate-Craniofacial Journal is a bi-monthly international, interdisciplinary journal on craniofacial anomalies. The journal explores and reports on the study and treatment, including experimental and proven surgical procedures, of cleft lip/palate and craniofacial anomalies. It also keeps readers in touch with the latest research in related laboratory sciences. To learn more about the society, please visit http://www.acpa-cpf.org/.

Read the full story at http://www.prweb.com/releases/2013/4/prweb10638358.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. Flexible Sensors Offer Unprecedented View of Brain Activity During Epileptic Seizures
2. 2011 ErgoExpo Attendees Choice Award Winners Announced During Sold Out Expo; Exhibitor Renewal for 2012 Hits 96% and Counting
3. SuperNova Diagnostics® to Present at Biotech Showcase™ 2012 During JP Morgan Healthcare Conference January 9 - 12
4. Natural Solutions to Fight Depression and Anxiety During the Holiday Season
5. Opedix® Joint Support Compression Apparel Unveils New CORE-Tec™ Shorts, Tested to Improve Core Stability, and Offer Support for Low Back Pain during Athletic Activities
6. Lucintel Report Outlines Significant Growth Opportunities for Continuous Fiber Thermoplastic Industry Players During 2012-2017
7. Genuine Bio-Fuel Inc. Notes Sustainable Energy Gets A Much Needed Boost from the President Obama During 2013 Inaugural Address
8. Lucintel Estimates Moderate Growth for Global Pulp and Paper Chemical Industry during 2012-2017
9. Thomson Reuters to Host tranSMART Community Meeting During BIO-IT World Conference
10. Upsher-Smith Launches B-Nexa® Prescription Prenatal Vitamin With B Vitamins and Ginger for Nausea and Vomiting of Pregnancy
11. Morning Sickness or NVP: National Survey of Nurse Practitioners Points to Underreporting of Common Condition in Pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2016)... The global Pyrogen Testing Market ... dominant share in the overall market. The leading players, ... Merck KGaA, held a lion,s share of 51% in ... that these companies are expected to retain their leadership ... do not require rabbit pyrogen testing along with strategic ...
(Date:11/30/2016)... , Nov. 30, 2016  The Allen ... Cell Collection: the first publicly available collection of ... cells that target key cellular structures with unprecedented ... Research, these powerful tools are a crucial first ... to better understand what makes human cells healthy ...
(Date:11/30/2016)... SAN DIEGO and BEIJING ... Ltd., a leading commercial provider of genomic services and ... expertise, announced today that it has completed a USD ... China Merchants Bank Co., Ltd.,s CMB International Capital Management ... SDIC Innovation Investment Management Co., Ltd. ("SDIC Innovation") and ...
(Date:11/30/2016)... Mass. , Nov. 30, 2016   Merck ... that it has entered into a set of agreements ... services for Merck,s collection of genetic reagents such as ... with Evotec,s screening expertise offers an accelerated pathway to ... discovery starts with the identification of new targets, a ...
Breaking Biology Technology:
(Date:6/22/2016)... 22, 2016 On Monday, the Department of ... to share solutions for the Biometric Exit Program. The ... Border Protection (CBP), explains that CBP intends to add ... the United States , in order to ... imposters. Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... 20, 2016 Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring announced ... it has secured the final acceptance by all ... Managed Access Systems (MAS) installed. Furthermore, Securus will ... be installed by October, 2016. MAS distinguishes between ...
(Date:6/15/2016)... June 15, 2016 Transparency ... titled "Gesture Recognition Market by Application Market - Global Industry Analysis ... 2024". According to the report, the  global gesture recognition ... 2015 and is estimated to grow at a ... by 2024.  Increasing application of gesture ...
Breaking Biology News(10 mins):