Mosquito genes linked to insecticide resistance may be new target in fight again...(ry Ranson of the Liverpool School of Tro...)

Date:2/4/2009

ry Ranson of the Liverpool School of Tropical Medicine, a co-author of the study, explained that what makes this finding remarkable is that this particular type of cytochrome P450s were also recently implicated in pyrethroid resistance in Anopheles gambiae, the other major malaria-carrying mosquito in Africa. "If the enzymes responsible for resistance are very similar in both species, there is a much greater incentive to invest efforts in identifying specific enzyme inhibitors with the knowledge that they will likely be effective at overcoming resistance in both major malaria vectors," said Ranson. Furthermore, Ranson noted it is critical that these mosquito P450 genes do not have close relatives in the human genome, meaning that targets developed against these mosquitoes should have low risk for toxicity in humans.

This report of genetic markers that can be used to predict insecticide resistance in laboratory populations of An. funestus may be a landmark finding in malaria prevention when applied to the evaluation of wild mosquito populations. "Routine use of these molecular markers for resistance will provide early warning of future control problems due to insecticide resistance and should greatly enhance our ability to mitigate the potentially devastating effects of resistance on malaria control," said Ranson.

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Contact: Peggy Calicchia calicchi@cshl.edu 516-422-4012 Cold Spring Harbor Laboratory Source:Eurekalert

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