More evidence for longevity pathway (found no discernable improvement in mito...)

More evidence for longevity pathway

Date:5/1/2012

found no discernable improvement in mitochondrial function. In contrast, the mice with normal SIRT1 function given resveratrol showed dramatic increases in energy.

While the tantalizing prospect of increasing healthy lifespan has made resveratrol the subject of intense scientific interest, some researchers have questioned the link to SIRT1. A competing theory holds that resveratrol may work by activating a separate energy pathway called AMPK, which, while also related to mitochondria, does not involve sirtuin genes.

In their new paper, Sinclair and colleagues report that when mice lacking SIRT1 were given low doses of resveratrol, AMPK was unaffected. When doses were significantly increased in these mice, AMPK was activated, but still no benefit to mitochondrial function resulted.

"Resveratrol is a dirty molecule, so when you give very, very high doses, many things could be happening," said Sinclair. "It's standard when you study molecules that you use the lowest dose that gives you an effect because of the risk of hitting other things if you use too much. But for the downstream benefits on energy, you still need SIRT1. Our paper shows that SIRT1 is front and center for any dose of resveratrol."

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Contact: Valerie Wencis
valerie_wencis@hms.harvard.edu
617-432-8024
Harvard Medical School
Source:Eurekalert

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GOOD

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