Navigation Links
More evidence for longevity pathway

New research reinforces the claim that resveratrola compound found in plants and food groups, notably red wineprolongs lifespan and health-span by boosting the activity of mitochondria, the cell's energy supplier.

"The results were surprisingly clear," said David Sinclair, a professor of genetics at Harvard Medical School and the study's senior author. "Without the mitochondria-boosting gene SIRT1, resveratrol does not work."

The findings are to be published May 1 in the journal Cell Metabolism.

Over the last decade, Sinclair and colleagues including Leonard Guarente at Massachusetts Institute of Technology have published a body of research describing how resveratrol improves energy production and overall health in cells by activating a class of genes called sirtuins that are integral to mitochondrial function. The cell's power supplier, mitochondria are essential not just for longevity but for overall health.

Sinclair and colleagues had studied sirtuins in a variety of model organisms: yeast, worms, flies and mice. For the first three organisms they were able to thoroughly knock out SIRT1 and show that cells lacking the gene don't respond to resveratrol. But no one had been able to demonstrate the effect in mice, which die at birth without the SIRT1 gene.

In order to solve this obstacle, Nathan Price and Ana Gomes, graduate students in the Sinclair lab, spent three years engineering a new mouse model. These mice, seemingly normal in every way, were designed so that SIRT1 would systemically switch off when the mice were given the drug Tamoxifen.

"This is a drug inducible, whole body deletion of a gene," said Sinclair. "This is something that's rarely been done so efficiently. Moving forward, this mouse model will be valuable to many different labs for other areas of research."

The results were plain: when mice were given low doses of resveratrol after SIRT1 was disabled, the researchers found no discernable improvement in mitochondrial function. In contrast, the mice with normal SIRT1 function given resveratrol showed dramatic increases in energy.

While the tantalizing prospect of increasing healthy lifespan has made resveratrol the subject of intense scientific interest, some researchers have questioned the link to SIRT1. A competing theory holds that resveratrol may work by activating a separate energy pathway called AMPK, which, while also related to mitochondria, does not involve sirtuin genes.

In their new paper, Sinclair and colleagues report that when mice lacking SIRT1 were given low doses of resveratrol, AMPK was unaffected. When doses were significantly increased in these mice, AMPK was activated, but still no benefit to mitochondrial function resulted.

"Resveratrol is a dirty molecule, so when you give very, very high doses, many things could be happening," said Sinclair. "It's standard when you study molecules that you use the lowest dose that gives you an effect because of the risk of hitting other things if you use too much. But for the downstream benefits on energy, you still need SIRT1. Our paper shows that SIRT1 is front and center for any dose of resveratrol."


Contact: Valerie Wencis
Harvard Medical School

Related biology technology :

1. More Evidence Published That Epidemics of Childhood Obesity, Type 2 Diabetes and Metabolic Syndrome are Linked to Immunization
2. The Lancets New Online Medical Journal Helps Clinicians and Medical Researchers Find Practice-Changing Evidence Quickly and Easily
3. Cancer Clinics of Excellence (CCE) Releases 62nd Evidence-Based Treatment Protocol
4. Evidence of Ancient Hot Springs on Mars Detailed in Astrobiology Journal
5. Agendia Publishes Direct Evidence That MammaPrint Predicts Benefit of Chemotherapy in Breast Cancer
6. ULURU to Present Clinical Evidence and Advanced Research on Altrazeal at the Society for Advance Wound Care Conference for 2009
7. MichBio Leader Cites New Senate Biosciences Task Force and House Subcommittee as Evidence of States Growing Awareness of Industrys Economic Importance
8. CPM Resource Center and The Shams Group Partner To Help Hospitals Integrate Evidence-Based Clinical Content Into Information Systems
9. Evidence of macroscopic quantum tunneling detected in nanowires
10. OncoGenex Pharmaceuticals Announces OGX-427 Treatment Demonstrates Safety, Evidence of Declines in Circulating Tumor Cells and Reductions in Tumor Markers in a Phase 1 Cancer Trial
11. Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimers Disease
Post Your Comments:
(Date:11/24/2015)... November 24, 2015 SHPG ) announced today ... the Piper Jaffray 27 th Annual Healthcare Conference in ... 2015, at 8:30 a.m. EST (1:30 p.m. GMT). --> ... Officer, will participate in the Piper Jaffray 27 th Annual ... on Tuesday, December 1, 2015, at 8:30 a.m. EST (1:30 p.m. ...
(Date:11/24/2015)... Israel , Nov. 24, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) ... on December 29, 2015 at 11:00 a.m. Israel ... Electra Tower, 98 Yigal Allon Street, 36 th Floor, ... of Eric Paneth and Izhak Tamir to the ... Rami Skaliter as external directors; , approval of an amendment to ...
(Date:11/24/2015)... SAN FRANCISCO , Nov. 24, 2015 /PRNewswire/ ... today announced that Emily Leproust, Ph.D., Twist Bioscience ... Piper Jaffray Healthcare Conference on December 1, 2015 ... Palace Hotel in New York City. ... . Twist Bioscience is on ...
(Date:11/24/2015)... ... November 24, 2015 , ... InSphero AG, the leading supplier of ... has promoted Melanie Aregger to serve as Chief Operating Officer. , Having ... management team and was promoted to Head of InSphero Diagnostics in 2014. ...
Breaking Biology Technology:
(Date:11/20/2015)... OXFORD, Connecticut , November 20, 2015 ... biometric authentication company focused on the growing mobile commerce ... its CEO, Gino Pereira , was recently interviewed ... The interview will air on this weekend on ... Bloomberg Latin America . --> NXTD ) ...
(Date:11/19/2015)... 19, 2015  Although some 350 companies are actively ... a few companies, according to Kalorama Information. These include Roche ... the market share of the 6.1 billion-dollar molecular testing ... Market for Molecular Diagnostic s .    ... still controlled by one company and only a handful ...
(Date:11/18/2015)... ALBANY, New York , November 18, 2015 /PRNewswire/ ... Transparency Market Research has published a new market report ... Share, Growth, Trends, and Forecast, 2015 - 2021. According to ... bn in 2014 and is anticipated to reach US$29.1 ... 2015 to 2021. North America ...
Breaking Biology News(10 mins):