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Monogram and Dana-Farber Cancer Institute Initiate Evaluation of HERmark(TM) Breast Cancer Assay in Metastatic Breast Cancer
Date:9/23/2008

ents a novel approach to the study of HER2- positive breast cancer by virtue of its ability to make accurate measurements of HER2 and its homodimer in actual breast tumors," said Ian Krop, M.D., Ph.D., Assistant Professor of Medicine, Division of Medical Oncology at the Dana Farber Cancer Institute and principal investigator of the study. "We look forward to working with Monogram on this study to try to develop a better understanding of the biology of HER2 positive breast cancer and the biomarkers that influence its clinical outcome."

About HERmark

HERmark is a proprietary diagnostic that accurately quantifies HER2 total protein levels and HER2 homodimerization in patients with breast cancer. HERmark is a CLIA-validated assay that is performed exclusively in Monogram's CAP-certified clinical reference laboratory in South San Francisco. Robust, accurate, sensitive and reproducible measurements of HER2 status are reported to physicians with a turnaround time of 7 days.

With the accurate measurements provided by HERmark, it is expected that as many as 15-20% of patients determined by conventional technologies to be HER2- negative would be reclassified by HERmark.

About Monogram

Monogram is advancing individualized medicine by discovering, developing and marketing innovative products to guide and improve treatment of serious infectious diseases and cancer. The Company's products are designed to help doctors optimize treatment regimens for their patients that lead to better outcomes and reduced costs. The Company's technology is also being used by numerous biopharmaceutical companies to develop new and improved anti-viral therapeutics and vaccines as well as targeted cancer therapeutics. More information about the Company and its technology can be found on its web site at http://www.monogrambio.com.

About Dana-Farber Cancer Institute

Dana-Farber Cancer Institute is a p
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SOURCE Monogram Biosciences, Inc.
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