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Monogram HIV Antibody Assay Is Key Component of Innovative Vaccine Development Program
Date:3/31/2008

Molecular Evolution Created Genetic and Antigenic Diversity and Improved Overall Immunogenicity of HIV-1 gp12- Immunogen," which detailed Maxygen's program to recombine and manipulate viral envelope DNA in order to produce vaccines which can neutralize a broad number of HIV variants. Other abstracts, presented during poster sessions, included:
-- Comparison of Trimeric Motifs for Their Effects on Trimer Formation,

Antigenicity and Immunogenicity of a Non-cleavable JRCSF HIV-1 gp140

Immunogen;

-- ParallelaVax(TM) Technology for High-Throughput HIV-1 Vaccine

Screening; and

-- Broad Survey of the Immunogenicity of HIV-1 Envelope Proteins.

"Our approach to developing a successful HIV vaccine is grounded in our ability to thoroughly and rapidly examine how well our immunogenetic candidates produce virus-neutralizing antibodies in animal models," said Maxygen Director of Infectious Diseases, Robert Whalen, D.Sc. "Our partnership with Monogram has been critical to our program's speed, productivity and progress towards a viable HIV vaccine."

About Maxygen

Maxygen is a biopharmaceutical company focused on developing improved versions of protein drugs. The company's lead program, MAXY-G34, is designed to be an improved version of long-acting G-CSF for the treatment of neutropenia. MAXY-G34 is currently in Phase II clinical trials. Also in Maxygen's pipeline are a new Factor VIIa product candidate for the treatment of hemophilia and new CTLA4-Ig product candidates for the treatment of rheumatoid arthritis. Maxygen uses its proprietary DNA shuffling technology and extensive protein modification expertise to pursue the creation of biosuperior proteins. http://www.maxygen.com

About Monogram

Monogram is advancing individualized medicine by discovering, developing and marketing innovative products to guide and improve treatment of serious infectiou
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SOURCE Monogram Biosciences, Inc.
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Cell Proliferation Kit, For 100 slides. Immunocytochemistry.Sample types: suitable for in vivo and in vitro tissue labeling.Recommended cell number: 10 6-107 cells/ml.2-3 h post-labeling (labeling 1
Laminin beta-2 (C4)
Anti-MD-2 (IN) Host: rabbit polyclonal Species Reactivity: human, mouse, rat Applications: WB, IHC Storage: 4C
VMAT 2 (N-19)
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