Navigation Links
Monogram Biosciences Launches First Resistance Assay for HIV Integrase Inhibitors
Date:8/4/2008

PhenoSense(R) Integrase Now Enables Clinicians to Monitor Activity of New

Class of Potent Antiretroviral Drugs

SOUTH SAN FRANCISCO, Calif., Aug. 4 /PRNewswire-FirstCall/ -- Monogram Biosciences, Inc. (Nasdaq: MGRM) today announced the launch of its PhenoSense(R) Integrase assay, built on Monogram's proprietary technology platform, PhenoSense(R). The assay directly measures the susceptibility of HIV to a new and potent class of integrase inhibitor drugs that blocks viral replication by preventing viral genes from integrating into the DNA of newly infected cells. Together with PhenoSense GT(R), PhenoSense Integrase provides the most complete picture of resistance to antiretroviral therapies.

PhenoSense Integrase along with other Monogram assays were used to support the clinical trials of the first commercially-available integrase inhibitor, Merck's Isentress(TM) (raltegravir), which received U.S. Food and Drug Administration (FDA) approval in October 2007. In Merck's phase III BENCHMRK trials, Monogram's PhenoSenseGT was used to select optimized drug regimens in the placebo and Isentress-containing treatment arms while PhenoSense Integrase was used to identify and characterize Isentress resistant viruses in treatment failures. The company is also actively involved in the clinical evaluation of Gilead's integrase inhibitor candidate, elvitegravir, currently in Phase III studies. In addition to drug resistance, PhenoSense Integrase also measures reductions in viral replication capacity associated with integrase inhibitor resistance that may help characterize viral fitness.

"Using new antiretroviral drugs correctly today, including HIV integrase inhibitors, is critically important since the pipeline for
'/>"/>

SOURCE Monogram Biosciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

1

GOOD

Page: 1 2 3 4 5

Related biology technology :

1. Monogram Biosciences to Present at the Thomas Weisel Partners Healthcare Conference 2007
2. Monogram Biosciences to Present at the ThinkEquity Partners Fifth Annual Growth Conference
3. Monogram Biosciences to Present at the JMP Securities Healthcare Conference
4. Monogram Biosciences Announces Third Quarter 2007 Financial Results Conference Call
5. Monogram Announces Third Quarter 2007 Financial Results
6. Monogram Biosciences to Present at the Piper Jaffray 19th Annual Healthcare Conference
7. Monogram Biosciences Announces Fourth Quarter 2007 Financial Results Conference Call
8. Data Presented on Monogram HIV Tropism Tests at Retrovirus Conference sets New Standards of Assay Sensitivity
9. Monogram Biosciences and Avexa Announce Exclusive Collaboration to Support New HIV Drug Discovery and Development Efforts
10. Monogram Announces Promotion of Gordon Parry, PhD, to Vice President, Research and Development, Oncology
11. Monogram HIV Antibody Assay Is Key Component of Innovative Vaccine Development Program

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/25/2009)...o Speak at Economic Club of Canada , ...009 -- Ambassador to Speak at Economic Club of Can... for International Investment, and Chairman and CE...phy of David Appia go to www.investinfrance.org ....t with press to discuss recent pro-business initia...
(Date:11/25/2009)...wswire/ - Cytochroma today announced the appointme...Dr. Moldt will replace Mr. Ulrik Spork as the Novo...mber of Board members remains unchanged at six mem...Moldt to the board and look forward to benefiting ...tinues to make progress in becoming a leading CKD-...
(Date:11/25/2009)...RNewswire/ -- Reportlinker.com announces that a ne...ogue: ,, Brazil Bioethanol Market Analysis and....com/p0165503/Brazil-Bioethanol-Market-Analysis-an...Market Analysis and Forecasts to 2013 ,, Summa...d forecasts of the global bioethanol market and th...
(Date:11/24/2009)...n . , Whether it,s CD packaging, containers ...y Identification) are increasingly finding their w...bel objects or goods and identify them automatical... read and process the data contained in the label....tion conditions of up to 100 degrees Celsius. But ...
Breaking Biology Technology:French Ambassador for International Investment to Visit Toronto December 11 2Cytochroma Announces Appointment of Peter Moldt to Board of Directors 2Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 2Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 3Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 4Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 5Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 6Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 7Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 8Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 9Reportlinker Adds Brazil Bioethanol Market Analysis and Forecasts to 2013 10Intelligence inside metal components 2
...0 Wisconsin business executives, economic developm...on in an effort to recruit and attract the biotech...legation will be attending BIO 2003, the annual me...BIO), June 21-25 at the Washington, D.C. Conventio...nd promotional initiative advertised as the worlds...
...y years ago, but he hasn,t given up preaching. , ...or and speaker on all things Internet spotlights o...to forsake them. , ,"The first requirement is to ...... what are those things about our culture that p...ning innovative and creative thinking and then do...
...ystems, and other such technologies are coming fro...aunched from within the enterprise as well out. Th...er attacks are increasing at an alarming rate, a p...August meeting of eInnovate. , ,On the very day co... the world, the message to this group wasnt startl...
Other Biology Technology:Governor To Lead Tech Delegation to Washington 2Governor To Lead Tech Delegation to Washington 3Dream Thieme 2Are You Prepared To Lose Your Identity? 2Are You Prepared To Lose Your Identity? 3
(Date:11/24/2009)...bridge, Md. (November 24, 2009) New research on b...iver ecosystems reveals predictable temporal patte...mmunities as markers for monitoring climate change...eek in the Proceedings of the National Academy of...munities in the six rivers shifted synchronously o...
(Date:11/23/2009)... Cambridge, Mass. November 23, 2009 Applied math...n lily ( Hosta lancifolia ), a characteristic long...y packed ripples along the edges. The simple cause...sulting from bending during differential growthwas...retching foam ribbons. , Haiyi Liang, a postdoct...
(Date:11/23/2009)...mington, CT Current research suggests that a comm...e. The related report by Nichols et al, "Unique L...w Class of TLR2 Ligands Capable of Enhancing Autoi...e American Journal of Pathology . , Multiple sc...tacks the brain and spinal cord, affects nearly 1 ...
Breaking Biology News(10 mins):Researchers establish common seasonal pattern among bacterial communities in Arctic rivers 2The cause behind the characteristic shape of a long leaf revealed 2Factors from common human bacteria may trigger multiple sclerosis 2Garner to Lead Virginia Bioinformatics Institute 14513 1Garner to Lead Virginia Bioinformatics Institute 14513 2Garner to Lead Virginia Bioinformatics Institute 14513 3Health care is only part of the puzzle 3A Social scientists analyze societys health and success 59662 1Health care is only part of the puzzle 3A Social scientists analyze societys health and success 59662 2Health care is only part of the puzzle 3A Social scientists analyze societys health and success 59662 3Fish vision discovery makes waves in natural selection 10401 1Fish vision discovery makes waves in natural selection 10401 2Fish vision discovery makes waves in natural selection 10401 3
...with implications for pandemic influenza, a new st...t strain of avian influenza virus can spread from ...tober 1 issue of The Journal of Infectious Disease...rrier is an important step in the development of a...es have focused on the ability of highly pathogeni...
...ersity will lead a new $52.7 million research prog...play in life,s most fundamental processes and poin...rection of Rutgers Professor Gaetano Montelione, t... will conduct the five-year undertaking. , "This g... reinforce our dynamic position in the biomedical ...
...y released method to analyze functional magnetic r...esearchers have demonstrated that the interconnect...mic and not static. This and other findings answer...rate to solve different cognitive tasks. They are ...rnal of Neuroscience. , Equally important, the res...
Other Biology News:Eating, body weight regulated by specific neurons 2Rutgers to lead $52.7 million protein research program 2Rutgers to lead $52.7 million protein research program 3Rutgers to lead $52.7 million protein research program 4Brain networks change according to cognitive task 2Brain networks change according to cognitive task 3
GIBCO Keratinocyte-SFM (1X) liquid from Invitrogen
GIBCO Dulbecco's Phosphate-Buffered Saline (D-PBS) (1X) liquid from Invitrogen
GIBCO Penicillin-Streptomycin liquid from Invitrogen
GIBCO Streptomycin Sulfate from Invitrogen
Biology Products: