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Monogram Announces Promotion of Gordon Parry, PhD, to Vice President, Research and Development, Oncology
Date:3/25/2008

HER2 homodimers. In several clinical cohorts of patients with metastatic breast cancer who were selected with conventional HER2 assays, quantitative levels of HER2 and HER2:HER2 homodimers, as measured by HERmark, correlate with clinical outcomes following treatment with the HER2-directed monoclonal antibody trastuzumab (Herceptin(R), Genentech), suggesting that the assay can stratify patients with breast cancer according to their degree of susceptibility to the drug. Additional studies of HERmark in the adjuvant setting are in progress.

The VeraTag technology platform provides accurate and quantitative measurements of proteins and activated proteins, including protein dimers. Initial assay development is directed at the measurement of activated epidermal growth factor receptor (EGFR) and other HER receptor family members that are directly targeted by approved cancer therapies. VeraTag assays will potentially enable healthcare providers to identify the appropriate course of treatment for cancers that have a particular molecular profile. VeraTag assays may also be developed to measure other proteins and signaling pathways that are key drivers of proliferation and survival in cancer cells.

About Monogram

Monogram is a biotechnology company advancing individualized medicine by discovering, developing and marketing innovative products to guide and improve treatment of serious infectious diseases and cancer. The Company's products are designed to help doctors optimize treatment regimens for their patients that lead to better outcomes and reduced costs. The Company's technology is also being used by numerous biopharmaceutical companies to develop new and improved antiviral therapeutics and vaccines as well as targeted cancer therapeutics. More information about the Company and its technology can be found on its web site at http://www.monogrambio.com.

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