Navigation Links
Molecular machine could hold key to more efficient manufacturing
Date:1/10/2013

An industrial revolution on a minute scale is taking place in laboratories at The University of Manchester with the development of a highly complex machine that mimics how molecules are made in nature.

The artificial molecular machine developed by Professor David Leigh FRS and his team in the School of Chemistry is the most advanced molecular machine of its type in the world. Its development has been published in the journal Science.

Professor Leigh explains: "The development of this machine which uses molecules to make molecules in a synthetic process is similar to the robotic assembly line in car plants. Such machines could ultimately lead to the process of making molecules becoming much more efficient and cost effective. This will benefit all sorts of manufacturing areas as many manmade products begin at a molecular level. For example, we're currently modifying our machine to make drugs such as penicillin."

The machine is just a few nanometres long (a few millionths of a millimetre) and can only be seen using special instruments. Its creation was inspired by natural complex molecular factories where information from DNA is used to programme the linking of molecular building blocks in the correct order. The most extraordinary of these factories is the ribosome, a massive molecular machine found in all living cells.

Professor Leigh's machine is based on the ribosome. It features a functionalized nanometre-sized ring that moves along a molecular track, picking up building blocks located on the path and connecting them together in a specific order to synthesize the desired new molecule.

First the ring is threaded onto a molecular strand using copper ions to direct the assembly process. Then a "reactive arm" is attached to the rest of the machine and it starts to operate. The ring moves up and down the strand until its path is blocked by a bulky group. The reactive arm then detaches the obstruction from the
'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Scientists design, control movements of molecular motor
2. Study identifies targeted molecular therapy for untreatable NF1 tumors
3. Caris Sponsors CancerCare Connect Education Workshop on Molecular Profiling in the Treatment of Breast Cancer
4. Karmanos Cancer Center first in Midwest to offer latest Molecular Breast Imaging
5. Caris Life Sciences mejora la evaluaciĆ³n por perfil molecular con los biomarcadores ROS1 y MGMT-metilaciĆ³n
6. Caris Life Sciences Enhances Molecular Profiling Service with Addition of ROS1 and MGMT-Methylation Biomarkers
7. A firm molecular handshake needed for hearing and balance
8. USC Center For Applied Molecular Medicine To Honor Sumner Redstone And Murray Gell-Mann, Ph.D. At The Inaugural REBELS WITH A CAUSE Gala
9. Merrimack Pharmaceuticals To Present Preliminary Clinical Data For Novel Therapies Targeting Molecular Pathways In Advanced Cancers
10. Indian Pharma MNC Piramal Investing in German Molecular Imaging Technology
11. Spectrometry Market (Atomic, Molecular and Mass Spectrometry) - Global Scenario, Trends, Industry Analysis, Size, Share & Forecast 2011 - 2017
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... , Aug. 27, 2014 Rhythm, a biopharmaceutical ... genetic deficiencies that result in metabolic disorders, announced today ... S-1 with the U.S. Securities and Exchange Commission (SEC) ... of its common stock. The number of shares to ... have not yet been determined. Citigroup and ...
(Date:8/27/2014)... nature,s mysteries is how plants survive impact by ... sun,s rays, while using this energy for photosynthesis. ... the plant,s blades quickly dissipate the energy throughout ... Researchers at DTU Physics have now managed to ... and bacteria contain light-absorbing proteins which play a ...
(Date:8/27/2014)... ANGELES , Aug. 27, 2014  Lisa Kulik ... years this July 4 holiday, thanks to a groundbreaking ... Ph.D., an internationally renowned clinician-researcher at the University of ... a 55-year-old Peoria, Ariz. resident ... robs its victims of sight. On June 2, she ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportbuyer.com has ... The Graphene Opportunity - A Rational View ... The New Nanotech? A similar amount of ... applications ranging from microelectronics to water treatment, but ... the availability of the Graphene Opportunity Report, authored ...
Breaking Biology Technology:Rhythm Files Registration Statement for Proposed Initial Public Offering 2DTU researchers film protein quake for the first time 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 2USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 3USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 4USC Eye Institute ophthalmologists implant first FDA-approved Argus II retinal prosthesis in western United States 5The Graphene Opportunity - A Rational View 2The Graphene Opportunity - A Rational View 3The Graphene Opportunity - A Rational View 4
... Highlights: -- $1.2 million contract signed for Phase III schizophrenia study, ... ... million -- $3 ... CogState Ltd (ASX: CGS),today announced that it has signed a contract with an ...
... and GUANGZHOU, China, August 12, - Major ... in U.S. Animal Models, An internationally renowned ... from experiments conducted by his,research team. This study ... in the treatment and prevention of,H5N1, H1N1 and ...
... BioSpecifics,Technologies Corp. (OTC Bulletin Board: BSTC.OB), a biopharmaceutical,company ... results for the second quarter ended June 30, 2008., ... for the quarter ended June,30, 2008, or 14 cents ... of,$478,000, or 9 cents per diluted common share, for ...
Cached Biology Technology:Sales Contracts Worth $2.3 Million Signed Since 1 July 2008 2Canopus Biopharma and Leading Chinese Researcher Team Up to Treat Avian Influenza, to Prevent Possible Pandemic 2Canopus Biopharma and Leading Chinese Researcher Team Up to Treat Avian Influenza, to Prevent Possible Pandemic 3Canopus Biopharma and Leading Chinese Researcher Team Up to Treat Avian Influenza, to Prevent Possible Pandemic 4BioSpecifics Technologies Corp. Reports Second Quarter 2008 Financial Results 2BioSpecifics Technologies Corp. Reports Second Quarter 2008 Financial Results 3BioSpecifics Technologies Corp. Reports Second Quarter 2008 Financial Results 4BioSpecifics Technologies Corp. Reports Second Quarter 2008 Financial Results 5BioSpecifics Technologies Corp. Reports Second Quarter 2008 Financial Results 6
(Date:8/27/2014)... FREMONT, Calif. , Aug. 27, 2014  WaferGen ... completed its previously announced underwritten public offering of units ... $10,000 per unit for gross proceeds of $20 million, ... expenses payable by the Company.  The shares and warrants ... Each unit sold in the offering consists ...
(Date:8/27/2014)... 27, 2014 Reportlinker.com announces that a ... catalogue: Law Enforcement Biometrics Market in ... About Biometrics Biometrics is a ... basis of their physical or behavioral patterns. It ... traits such as fingerprints, face recognition, DNA, palm ...
(Date:8/27/2014)... cells to rearrange existing patterns of activity than when ... study of monkeys has found. The scientists explored the ... of brain cell networks. The study was partly funded ... into the brain and may have seen why it,s ... Batista, Ph.D., an assistant professor at the University of ...
Breaking Biology News(10 mins):WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 3Law Enforcement Biometrics Market in North America 2014-2018 2Law Enforcement Biometrics Market in North America 2014-2018 3Law Enforcement Biometrics Market in North America 2014-2018 4Law Enforcement Biometrics Market in North America 2014-2018 5Scientists plug into a learning brain 2Scientists plug into a learning brain 3
... say they have assembled more completely the string of ... to imitate their owners and other sounds. The ... genome using a new technology, single molecule sequencing, and ... The team also decoded hard-to-sequence genetic material from corn ...
... by chemists in the Baruch ,60 Center for Biochemical ... to detail the individual steps of highly efficient reactions ... bacteria. In a paper published in the recent ... Energy & Environmental Science , the scientists ...
... from invasive species and the risk of wildfire is ... research on the Island of Hawaii. It is commonly ... species will restore the land to its original state. ... Invasions , Dr. Susan Cordell, USDA Forest Service Pacific ...
Cached Biology News:DNA sequenced for parrot's ability to parrot 2DNA sequenced for parrot's ability to parrot 3Rensselaer scientists unlock some key secrets of photosynthesis 2Rensselaer scientists unlock some key secrets of photosynthesis 3Native plant restoration not enough to maintain tropical dry forests in Hawaii 2
... Second Mitochondria Derived Activator of ... 20 mM HEPES, pH 7.5 AVOID FREEZE/THAW CYCLES. ... Smac/DIABLO with a carboxy terminal His•Tag ® ... E. coli . Smac/DIABLO is released along with ...
...
... Fixed clamp trays and universal ... Magnetic drive Shaking ... 25 mm amplitude ... to 2000 ml, including Fernbach flasks ...
... the NEW VSOS-4P, all Programmable and Digital Orbital ... now been redesigned to make every day use ... Programmable memory for up to 4 different programs. ... of your program. Furthermore, the VSOS-4P has a ...
Biology Products: