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Modulation of inhibitory output is key function of antiobesity hormone
Date:7/13/2011

urons are less active. Conversely, a reduction in leptin levels, such as occurs with fasting, increases the activity of these GABA neurons.

Taken together, the findings suggest that modulation of GABA output is a key aspect of leptin action. "Leptin working directly on GABA neurons reduces inhibitory tone to POMC neurons," concludes Dr. Lowell. "As POMC neurons prevent obesity, their disinhibition by leptin action on upstream GABA neurons likely mediates, at least in part, leptin's antiobesity effects. Further, indirect regulation of POMC neurons by leptin reconciles the known important role of POMC neurons in regulating body weight with the relatively unimportant role played by direct action of leptin on POMC neurons."


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Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

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