Navigation Links
Modulation of inhibitory output is key function of antiobesity hormone
Date:7/13/2011

Scientists have known for some time that the hormone leptin acts in the brain to prevent obesity, but the specific underlying neurocircuitry has remained a mystery. Now, new research published by Cell Press in the July 14 issue of the journal Neuron reveals neurobiological mechanisms that may underlie the antiobesity effects of leptin.

"Leptin is a hormone that is secreted by fat cells and acts at its receptor in the brain to decrease food intake and promote energy expenditure," explains senior study author Dr. Bradford B. Lowell from Beth Israel Deaconess Medical Center and Harvard Medical School. "However, despite intensive investigation, the underlying mechanisms responsible for this are poorly understood, in part due to incomplete knowledge regarding leptin-responsive neurons."

Previous studies by Dr. Lowell's group and others pinpointed a region of the brain called the arcuate nucleus as the site of key components related to the control of obesity. In particular, pro-opiomelanocortin (POMC) neurons, which have been shown to play a key role in appetite suppression, reside in this region. Although many POMC neurons express receptors for leptin, direct action of leptin on POMC neurons has not been shown to play a large role in controlling body weight. This suggests that there are likely to be other leptin-responsive neurons that are critical for leptin's antiobesity actions.

In the current study, Dr. Lowell and colleagues took a new approach for identifying these "unidentified" body weight-regulating neurons and investigated whether leptin's effects are mediated primarily by excitatory (glutamate) or inhibitory (GABA) neurons. "Remarkably, we found that leptin's antiobesity effects are mediated predominantly by GABA neurons and that glutamate neurons play only a small role," says Dr. Linh Vong, a first author on the study. Importantly, the GABA neurons are "upstream" of the POMC neurons and, in response to leptin, the GABA ne
'/>"/>

Contact: Elisabeth (Lisa) Lyons
elyons@cell.com
617-386-2121
Cell Press
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Neurologix Presents One-Year Follow-Up Data From Phase 2 Study of NLX-P101 in Parkinsons Disease at International Neuromodulation Society 10th World Congress
2. Victhom Human Bionics Receives CE Mark for the Neurostep(TM) System, the Worlds First Fully Implantable Closed-Loop Neuromodulation Therapy for Treatment of Foot Drop
3. Chinas Research Output More Than Doubled Since 2004, Thomson Reuters Study Reveals
4. Despite Decline in Share of Global Output, U.S. Science Impact Still Strong, Says Thomson Reuters
5. Molecular Devices Enables Intuitive Functionality at Your Fingertips on the Apple iPad with the Latest SoftMax Pro Software
6. Rhythms RM-131 Restores GI Function as a Potent Ghrelin Prokinetic
7. Functional Nutriments Awarded Federal Grant to Apply Its Dog Nutraceutical Research to Human Cancer
8. Creating Functional Hepatic Tissue in a Bioengineered Human Liver
9. Tengion Presents New Large Animal Data Demonstrating Functional Kidney Regeneration at the American Society for Transplantation Annual Conference
10. NephRx Corp. Receives Orphan Drug Designation for NX001 for Prevention of Delayed Kidney Graft Function
11. Prostate cancer risk variant found to be in a functional DNA sequence linked with disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2014)... , Nov. 27, 2014 ... the "Global Palmitic Acid Industry Report 2014" ... The Global Palmitic Acid Industry ... the current state of the global palmitic acid industry. ... the industry including definitions, classifications, applications and industry chain ...
(Date:11/27/2014)... USA (PRWEB) November 26, 2014 Biomedical ... accuracy, additive systems to enable 3D manufacture at the ... road conditions are among finalists in nine categories for ... The awards are sponsored by SPIE, the international ... Media . , Winners will be announced by industry ...
(Date:11/26/2014)... The North America Thermal Protective Clothing Market ... analysis of the growth trends and revenue forecasts. ... by 2018, growing at a CAGR of 7.1% ... TOC of the North America Thermal Protective Clothing ... in-depth analysis and industry segmentation supported by various ...
(Date:11/26/2014)... , Nov. 26, 2014 The ... results from a survey of European physicians at ... on Innovation and Biological Therapies" at the Spanish ... event, hosted by EuropaBio and the Spanish Bioindustry ... of Health, physicians from Spanish oncology and rheumatology ...
Breaking Biology Technology:Global Palmitic Acid Industry Report 2014 2Finalists Named for 2015 Prism Awards for Photonics Innovation 2Finalists Named for 2015 Prism Awards for Photonics Innovation 3Finalists Named for 2015 Prism Awards for Photonics Innovation 4Finalists Named for 2015 Prism Awards for Photonics Innovation 5The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3ASBM Presents European Physicians Survey at Spanish Ministry of Health 2
... May 11, 2009 Arena Pharmaceuticals, Inc. (Nasdaq: ... ended March 31, 2009. Arena reported a net loss allocable ... $50.6 million, or $0.68 per share, compared to a net ... 2008 of $55.0 million, or $0.75 per share. "Receiving the ...
... Inc. (Nasdaq: IDIX ) announced today that Idenix ... Bank 2009 Health Care Conference on Monday, May 18, 2009 ... and archived webcast of the company presentation can be accessed ... www.idenix.com . Please log in approximately ...
... 18, 2009 SAN DIEGO, May 11 Neurocrine Biosciences, ... Kevin Gorman, President and Chief Executive Officer of Neurocrine ... Annual Health Care Conference in Boston. The live presentation ... Eastern Time (ET)/2:05 p.m. Pacific Time (PT). The ...
Cached Biology Technology:Arena Pharmaceuticals Announces First Quarter 2009 Financial Results 2Arena Pharmaceuticals Announces First Quarter 2009 Financial Results 3Arena Pharmaceuticals Announces First Quarter 2009 Financial Results 4Arena Pharmaceuticals Announces First Quarter 2009 Financial Results 5Arena Pharmaceuticals Announces First Quarter 2009 Financial Results 6Arena Pharmaceuticals Announces First Quarter 2009 Financial Results 7Arena Pharmaceuticals Announces First Quarter 2009 Financial Results 8Neurocrine Biosciences to Present at the Deutsche Bank 34th Annual Health Care Conference 2
(Date:11/18/2014)... The Parenteral Drug Association (PDA) today confirmed that ... and at least seven more will participate in the upcoming ... Hotel in Washington D.C. , Dec. 2-4. ... support from the regulatory agencies in the United ... our effort to help advance the use of metrics in ...
(Date:11/12/2014)... , Nov. 12, 2014 Crossmatch™, a leading ... its U.are.U ® fingerprint readers have been deployed ... Central Mexico . The bakery chain ... eliminate payroll issues caused by employees clocking in for ... U.are.U fingerprint readers, Montparnasse relied on paper timecards and ...
(Date:11/7/2014)... associate professor, biomedical engineering, in the Grove School ... York, have identified a molecule that could lead ... aggressive forms of breast cancer. , Triple negative ... owing to aggressive proliferation and metastasis and a ... team, discovered the overexpression of intercellular adhesion molecule-1 ...
Breaking Biology News(10 mins):FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2
... Hospital (MGH) Cancer Center have identified a subgroup of ... drug cisplatin, rarely used in the treatment of breast ... of this sensitivity, which may help identify patients most ... will be tested in a clinical trial anticipated to ...
... delivered into the tumors of stage 4 lung cancer ... phase I clinical trial at The University of Texas ... found to be active in the metastatic non-small cell ... first-in-human study and we've seen an exciting proof of ...
... cut back on the amount of salt in their diet could ... to a report on bmj.com today. , Researchers in ... risk of death from cardiovascular disease by up to a fifth. ... diseases linked to the heart or arteries, for example a stroke ...
Cached Biology News:Molecular signature may identify cisplatin-sensitive breast tumors 2Molecular signature may identify cisplatin-sensitive breast tumors 3Intravenous nanoparticle gene therapy shows activity in stage IV lung cancer 2Eating less salt could prevent cardiovascular disease 2
Detects activated caspases in living cells. Simple/sensitive/straight-forward procedure takes only 30 minutes. Results can be analyzed by flow cytometry/fluorescence microscopy/fluorescence plate rea...
Apoptosis Detection Systems and Reagents...
Apoptosis Detection Systems and Reagents...
... rodent oral gavage feature soft rubber tips ... trauma. Plus they are disposable, to eliminate ... of cross-contamination. Diameter: ... Length: ...
Biology Products: