Navigation Links
Modeling Alzheimer's disease using iPSCs
Date:2/21/2013

Kyoto, Japan Working with a group from Nagasaki University, a research group at the Center for iPS Cell Research and Application (CiRA) at Japan's Kyoto University has announced in the Feb. 21 online publication of Cell Stem Cell has successfully modeled Alzheimer's disease (AD) using both familial and sporadic patient-derived induced pluripotent stem cells (iPSCs), and revealed stress phenotypes and differential drug responsiveness associated with intracellular amyloid beta oligomers in AD neurons and astrocytes.

In a study published online in Cell Stem Cell, Associate Professor Haruhisa Inoue and his team at CiRA and a research group led by Professor Nobuhisa Iwata of Nagasaki University generated cortical neurons and astrocytes from iPSCs derived from two familial AD patients with mutations in amyloid precursor protein (APP), and two sporadic AD patients. The neural cells from one of the familial and one of the sporadic patients showed endoplasmic reticulum (ER)-stress and oxidative-stress phenotypes associated with intracellular amyloid beta oligomers. The team also found that these stress phenotypes were attenuated with docosahexaenoic acid (DHA) treatment. These findings may help explain the variable clinical results obtained using DHA treatment, and suggest that DHA may in fact be effective only for a subset of patients.

Using both familial and sporadic AD iPSCs, the researchers discovered that pathogenesis differed between individual AD patients. For example, secreted amyloid beta 42 levels were depressed in familial AD with APP E693 delta mutation, elevated in familial AD with APP V717L mutation, but normal in sporadic AD.

``This shows that patient classification by iPSC technology may contribute to a preemptive therapeutic approach toward AD,'' said Inoue, a principal investigator at CiRA who is also a research director for the CREST research program funded by the Japan Science and Technology Agency. ``Further advances in iPSC technology will be required before large-scale analysis of AD patient-specific iPSCs is possible.''


'/>"/>

Contact: Akemi Nakamura
cira-pr@cira.kyoto-u.ac.jp
81-753-667-000
Center for iPS Cell Research and Application - Kyoto University
Source:Eurekalert  

Related biology technology :

1. NDIA, NTSA Will Be On Hand At Seventh Annual Capitol Hill Modeling and Simulation Expo, Set To Focus On Homeland Security, First Response
2. GUARDaHEART Foundation Hosts Love Your Heart Day Event in Celebration of Heart Disease Awareness Month
3. Anonymous survey launched for Parkinson’s patients to collect data for research to help determine the cause of Parkinson's disease.
4. Ingenuity Systems Announces Curation of All Human Disease Implicated Genetic Variation
5. Fighting disease deep inside the brain
6. The In View series hosted by Larry King Announces plans for a series on Autoimmune Diseases
7. Heptares to Moderate Panel on Rare Diseases at BBC New York CEO Meeting (13-14 February)
8. American Heart Month: Find New Heart Disease Treatments on cureLauncher
9. Amarantus BioScience Reports Statistical Significance Achieved for MANF Striatal Reinnervation in Neurorestoration Animal Model of Parkinsons Disease
10. Aviir Sponsors Eco Hideaway 2013 Music Artist Stage At The Chateaux In Park City, Utah To Benefit Heart Disease
11. Transition in cell type parallels treatment response, disease progression in breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Modeling Alzheimer's disease using iPSCs
(Date:1/19/2017)... ... January 19, 2017 , ... ... software solutions for pharmaceutical research and development (R&D), today announced the launch ... data analysis and interpretation for the rapidly evolving field of precision medicine. ...
(Date:1/19/2017)... ... January 18, 2017 , ... The ... (NIH) to update its Data Sharing Policy. Specifically, the nation’s leading informatics experts, ... subject to the existing policy. AMIA recommended that NIH earmark funding for researchers ...
(Date:1/19/2017)... Md. , Jan. 18, 2017  Northwest Biotherapeutics, ... developing DCVax® personalized immune therapies for operable and inoperable ... Bosch , Chief Technical Officer of NW Bio, will ... January 19, 2017, at the Hyatt Regency Hotel in ... Bosch will chair the session entitled "New Therapeutic Approaches ...
(Date:1/18/2017)... Jan. 18, 2017   Boston Biomedical , an ... to target cancer stemness pathways, will feature data from ... at the 2017 ASCO Gastrointestinal Cancers Symposium, held from ... Napabucasin is an orally-administered investigational agent ... i Cancer stem cells (CSCs) possess the property ...
Breaking Biology Technology:
(Date:1/6/2017)... 2017  Privately-held CalciMedica, Inc., announced that it ... of a novel calcium release-activated calcium (CRAC) channel ... Acute pancreatitis, sudden painful inflammation of ... can be very serious.  In severe cases it can ... hospital stays, time in the ICU and substantial ...
(Date:1/4/2017)... VEGAS , Jan. 4, 2017  CES ... performance biometric sensor technology, today announced the launch ... sensor systems, the highly-accurate biometric sensor modules ... biometric technology, experience and expertise. The two ... Benchmark designed specifically for hearables, and Benchmark BW2.0, ...
(Date:12/20/2016)... Dec. 20, 2016 The rising popularity ... and leasing is stoking significant interest in keyless ... technology, Bluetooth low energy (BLE), biometrics and near-field ... next wave of wireless technologies in the automotive ... to advanced access systems opens the market to ...
Breaking Biology News(10 mins):