Navigation Links
Model of viral lifecycle could help in finding a cure for hepatitis B
Date:8/4/2014

ble," she says. "It's a very finicky cell, and when you isolate it from the liver and try to culture it under conventional conditions, it rapidly loses its repertoire of liver functions."

So the team set out to develop a technique to keep the liver cells stable and functioning long enough to monitor their response to the virus and antiviral drugs.

They based their approach on a system they had previously developed for studying the hepatitis C virus, in which they were able to successfully infect human hepatocytes with the virus and use it to compare antiviral regimens.

The hepatocytes are first patterned onto surfaces dotted with tiny spots of collagen, and then surrounded by supportive tissue made up of stromal cells, which act as connective tissue and support the hepatocytes in carrying out their liver functions.

Two Complementary Systems

To apply the technique to infection with HBV, the researchers developed two complementary systems. One uses primary hepatocytes obtained from livers donated for transplant; the second uses stem cells derived from human skin samples and guided into hepatocyte-like cells, Bhatia says.

When they compared the relative merits of the two systems, they found that the primary liver cells had a stronger immune response when infected with the virus than the stem cell progeny. However, unlike the primary hepatocytes, the hepatocyte-like cells offer an unlimited supply of test cells, since the researchers can simply grow more as required, Bhatia says.

"But that being said, both systems were able to grow this persistent nuclear form [of HBV], so we think they offer complementary tools," she says.

To investigate whether the cell cultures could be used to test new treatments for the disease, the researchers monitored their response to two existing drugs. They found that the infected cultures responded to the drugs in the same way that liver cells inside the body are
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force
2. Improving Trial Design and Predictability in Rheumatoid Arthritis With Time Response Modeling, New Webinar July 23rd Hosted by Xtalks
3. AMA Recognized as the Focal Point for Aero-modeling
4. Mice Model Market worth $1,819.9 Million by 2018
5. Model Aviation Expo to Feature Radio Controlled Airplanes, Helicopters, Multirotors, UAVs, and FPVs
6. Arsenal Capital Partners übernimmt führendes Unternehmen für modellbasierte Arzneimittelentwicklung Certara
7. Arsenal Capital Partners verwerft Certara, leider in geneesmiddelontwikkeling op basis van modellen
8. Arsenal Capital Partners Acquires Leading Model-Based Drug Development Company Certara
9. ThoroughGen Creates First Genetic Breeding Model for Thoroughbreds
10. Model Aviation Clubs Raise $76,000 for the Wounded Warrior Project
11. A mouse model to evaluate potential age-promoting compounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... Grand Rapids, MI (PRWEB) November 22, 2014 ... the opportunity to simulate the proper management of ... training and test lung devices . Grand Rapids-based, ... Lung” plans to donate two of the respiratory ... $12,000 to $15,000 each. Grand Valley and Muskegon ...
(Date:11/21/2014)... Quebec , November 21, 2014 ... como responsable comercial   Mariano Rodríguez es ...   KLOX está en marcha para comenzar ... de cura de heridas de reciente aprobación en Europa   ... "la compañía") se complace al anunciar los siguientes nombramientos: ...
(Date:11/21/2014)... November 20, 2014 Offering a complete ... Sartorius Entris Balance promotion . The Sartorius Entris Balance ... durable, high accuracy, and easy-to-maintain balance entry level balance. ... It was designed to help customer’s bridge the gap ... balance that is very durable. Sartorius is the second ...
(Date:11/21/2014)... The report, "Synthetic Biology Market by ... Technology (Bioinformatics, Nanotechnology, Gene Synthesis, Cloning & ... Global Forecast to 2018", analyses and studies ... challenges. , Browse 99 market data tables ... and in-depth TOC of the global synthetic ...
Breaking Biology Technology:Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 2Michigan Instruments Donates Two Respiratory Simulation Training and Test Lung (TTL) Devices to Grand Valley State University 3KLOX Technologies anuncia sus nombramientos ejecutivos 2KLOX Technologies anuncia sus nombramientos ejecutivos 3KLOX Technologies anuncia sus nombramientos ejecutivos 4KLOX Technologies anuncia sus nombramientos ejecutivos 5Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 2Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 3Synthetic Biology Market Expected to Reach $5,630.4 Million in 2018 - New Report by MarketsandMarkets 4
... Reflects Full Scope of Integrated Global Services, ... Clinical,Trials today launches under a new name, Abt ... Associates Inc. The company will continue to,provide custom ... medical device and diagnostics industries,utilizing a team approach ...
... OF PRUSSIA, Pa., April 1, 2008 HighPoint Solutions,LLC, ... it,has been selected by a global biotechnology company to ... prepare for the company,s new,product launches and support its ... science companies continue to strive to create a holistic ...
... Increases 60% to $87.1 Million ... Increases 61% to $8.6 Million, XIAN, China, April ... Board: CBEH), (CBEH or the "Company"), an,energy company engaged ... finished oil products and the development, production and,distribution of ...
Cached Biology Technology:Abt Associates Clinical Trials Announces Name Change to Abt Bio-Pharma Solutions, Inc. 2HighPoint Solutions Selected by Global Biotechnology Company to Provide Master Data Management Solution 2China Bio Energy Reports Fiscal 2007 Financial Results 2China Bio Energy Reports Fiscal 2007 Financial Results 3China Bio Energy Reports Fiscal 2007 Financial Results 4China Bio Energy Reports Fiscal 2007 Financial Results 5China Bio Energy Reports Fiscal 2007 Financial Results 6China Bio Energy Reports Fiscal 2007 Financial Results 7China Bio Energy Reports Fiscal 2007 Financial Results 8China Bio Energy Reports Fiscal 2007 Financial Results 9China Bio Energy Reports Fiscal 2007 Financial Results 10China Bio Energy Reports Fiscal 2007 Financial Results 11
(Date:11/7/2014)... 6, 2014 Leading Biometric companies aim ... security revolutionizing online transactions.  Companies in focus today are: NXT-ID, ... BABA ), Google Inc. (NASDAQ: GOOG ... (NASDAQ: EBAY ) and MasterCard Inc. (NYSE: MA) ... NXTDW), a biometric authentication company focused on the growing mobile ...
(Date:11/5/2014)... in the UTSA College of Sciences, is one ... receive a two-year $300,00 National Science Foundation (NSF) ... funding supports President Obama,s BRAIN Initiative, a federal ... that will demystify complex brain processes. , ... broken into the interactions of multiple components, each ...
(Date:11/4/2014)... – Temple University School of Medicine announced today ... an initiative funded by the Bill & Melinda ... of Obstetrics, Gynecology and Reproductive Sciences; and Vice ... University School of Medicine will pursue an innovative ... Blood Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges ...
Breaking Biology News(10 mins):Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3Temple University School of Medicine receives Grand Challenges Explorations grant 2
... at the University of Leicester may identify reasons underlying ... men. In her doctoral study, Cardiovascular Sciences student ... male predominance of AAA, with a particular emphasis on ... study will be showcased at the University of Leicester,s ...
... KNOXVILLE -- By examining 800,000-year-old polar ice, scientists increasingly ... ice melt and that carbon dioxide has become more abundant ... scientist Jrme Chappellaz has been examining ice cores collected from ... His studies on the interconnecting air spaces of old snow ...
... climate change, carbon dioxide, pollution and other human-related phenomena on ... isolated sources of pollution and other influences. Now, a ... published a report in the latest issue of the journal ... factors on the ocean and considers what the future might ...
Cached Biology News:Increased likelihood of male death from disease 2Scientist links increase in greenhouse gases to changes in ocean currents 2 WHOI scientist takes comprehensive look at human impacts on ocean chemistry 2 WHOI scientist takes comprehensive look at human impacts on ocean chemistry 3
TACS Apoptotic DNA Laddering Kits are used to assay cells and tissues for apoptosis by...
RABBIT ANTI HUMAN APP (KP1 DOMAIN) Immunogen: Synthetic peptide composed of amino acids 292-312 from the KPI domain of human APP....
Anti-Goat HRP-AEC Cell & Tissue Staining Kit...
... culture systems provide an integrated ... for staining and imaging. Each ... preassembled with standard optical-quality coverslips ... entire system is provided sterile ...
Biology Products: