Navigation Links
Model of viral lifecycle could help in finding a cure for hepatitis B
Date:8/4/2014

CAMBRIDGE, MA -- A new technique for studying the lifecycle of the hepatitis B virus could help researchers develop a cure for the disease.

In a paper published today in the journal Proceedings of the National Academy of Sciences, Sangeeta Bhatia of MIT and Charles Rice of Rockefeller University describe using microfabricated cell cultures to sustain hepatitis B virus in human liver cells, allowing them to study immune responses and drug treatments.

Around 400 million people worldwide are infected with the hepatitis B virus (HBV); of those, one-third will go on to develop life-threatening complications, such as cirrhosis and liver cancer.

Although there is an effective HBV vaccine, only around 50 percent of people in some countries where the disease is endemic are vaccinated. A complete cure for the disease is very rare, once someone has been chronically infected.

"Once a liver cell is infected, the viral genome persists inside the nucleus, and that can reactivate later," says Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and Electrical Engineering and Computer Science. "So although we have a vaccine, it's important to find a way to study this persistent form of the virus to try to identify treatments that could efficiently clear it."

'Finicky' Hepatocytes

To develop a treatment for HBV, researchers need to be able to study infected liver cells, known as hepatocytes, so they can understand how the virus interacts with them.

But while researchers have previously been able to infect cultures of human hepatocytes with HBV, the cells' limited lifespan has made it difficult to study the virus, says Bhatia, who is also a Howard Hughes Medical Institute investigator and a member of MIT's Koch Institute for Integrative Cancer Research and Institute for Medical Engineering and Science.

"That's because the hepatocyte the main cell in the liver is unsta
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-253-8923
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force
2. Improving Trial Design and Predictability in Rheumatoid Arthritis With Time Response Modeling, New Webinar July 23rd Hosted by Xtalks
3. AMA Recognized as the Focal Point for Aero-modeling
4. Mice Model Market worth $1,819.9 Million by 2018
5. Model Aviation Expo to Feature Radio Controlled Airplanes, Helicopters, Multirotors, UAVs, and FPVs
6. Arsenal Capital Partners übernimmt führendes Unternehmen für modellbasierte Arzneimittelentwicklung Certara
7. Arsenal Capital Partners verwerft Certara, leider in geneesmiddelontwikkeling op basis van modellen
8. Arsenal Capital Partners Acquires Leading Model-Based Drug Development Company Certara
9. ThoroughGen Creates First Genetic Breeding Model for Thoroughbreds
10. Model Aviation Clubs Raise $76,000 for the Wounded Warrior Project
11. A mouse model to evaluate potential age-promoting compounds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/25/2014)... The report “Service Quality Management and Telco ... Type - Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” ... and forecasting of revenues. , Browse 152 market ... in-depth TOC on “Service Quality Management (SQM) and Telco ...
(Date:12/24/2014)... , Dec. 24, 2014   BioLife Solutions , Inc. (NASDAQ: ... of proprietary clinical grade hypothermic storage and ... for cells and tissues  ("BioLife" or the "Company"), today ... Stockholders on May 4, 2015 (the "Annual Meeting"). ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... designed to introduce cutting edge communication technology, provide ... platform upgrades. This webinar series demonstrates online communication ... to leverage web conferencing’s most innovative and powerful ...
(Date:12/24/2014)... Nashville Fertility Center announced that Dr. ... Society for Reproductive Medicine (ASRM), a leading professional organization committed ... his new role as treasurer, Dr. Hill also fills a ... in furthering the mission of ASRM. , Dr. Hill ...
Breaking Biology Technology:Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3
... Doyle gathered over 100 executives and leaders of ... to preview his new economic growth package. These ... leadership, The Wisconsin Technology Council as well many ... capitalists. The message they heard from governor was ...
... Patients Compensation Fund could be illegal , ,While ... support yesterday for Gov. Jim Doyles Grow Wisconsin program, ... support, but takes issue with the provisions for the ... criticism for Doyles proposed use of funds from the ...
... Its Saturday night. Your 4 year old has stomach pains, and ... all sorts of personal medical information including her medical history and ... and you try to remember if you told the person at ... two as the triage nurse does not see bleeding or an ...
Cached Biology Technology:Governor Gathers Biotech Leaders at his Residence 2Republicans criticize Doyles growth package 2Republicans criticize Doyles growth package 3Republicans criticize Doyles growth package 4Childrens Medical Hospital of Wisconsin Goes Digital 2Childrens Medical Hospital of Wisconsin Goes Digital 3Childrens Medical Hospital of Wisconsin Goes Digital 4
(Date:1/22/2015)... , Europe,s ... European Patent Office to present a video retrospective of the most ... featured: Christofer Toumazou and Sophie Wilson   ... of the Award   Starting on 22 January 2015 ...
(Date:1/22/2015)... Infinisource has launched its new NXG series of time ... sets a higher standard for collecting attendance and labor data ... plug-and-play installation, touch screen interface and seamless connection to cloud-based ... collection solution for the small to mid-size employer. ...
(Date:12/22/2014)... , Dec. 22, 2014 Research and Markets ... of the "The Global Watermarking and Fingerprinting ... http://photos.prnewswire.com/prnh/20130307/600769 This ... media watermarking and fingerprinting markets. Watermarking aims to ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3Infinisource's NXG series sets new time clock standard 2The Global Watermarking and Fingerprinting Markets 2
... 2009, six leading ecosystem researchers will share with lawmakers key ... This science briefing is part of the annual Association ... Cities around the nation are bracing for the impacts ... states to drought in the west, water will be at ...
... relief and a good cleansing for millions of Americans, ... pathogenic bacteria, according to a surprising new University of ... high-tech instruments and lab methods to analyze roughly 50 ... New York City, Chicago and Denver. They concluded ...
... of The 2009 Lasker Awards, announced today, represent the ... to a revolutionary cancer treatment and the tremendous promise ... portend a potential $700 million global market for new ... Genetic Engineering & Biotechnology News (GEN, www.genengnews.com ...
Cached Biology News:Daily bathroom showers may deliver face full of pathogens, says CU-Boulder study 2Daily bathroom showers may deliver face full of pathogens, says CU-Boulder study 3Daily bathroom showers may deliver face full of pathogens, says CU-Boulder study 42009 Lasker Awards recognize promise of stem cells -- global market could top $700 million 2