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Mimedx Scientific Study Is Electronically Published in The International Wound Journal
Date:8/1/2013

d in our previous press release, this research concludes that when applied to a chronic wound, our proprietary PURION® processed EpiFix® allografts act as a 'stem cell magnet.'  Essential to the repair of these wounds is the attraction, proliferation and migration of these pivotal regenerative cells to the wound site.  The 'stem cell magnet' action of our allografts revitalizes the tissue regeneration," stated Parker H. "Pete" Petit, Chairman and Chief Executive Officer.

Bill Taylor, President and Chief Operating Officer, said, "The normal wound healing process has three major phases:  Inflammation, Proliferation and Remodeling.  In the inflammation phase, the T-cells (white blood cells) come into the site and clean up the cellular debris, essentially preparing the site for healing.  The second phase is cell proliferation, where resident dermal fibroblasts proliferate and start creating a collagen matrix.  At the same time, endothelial cells and stem cells are recruited to the area to help form the vasculature.  The third phase is the remodeling phase where the wound closes and remodeling of the newly formed tissue occurs and completes the process. In chronic wounds, this entire process is compromised. However, when EpiFix® is applied to the chronic wound, the inflammation is modulated, and then our tissue helps multiple cell types, like endothelial and dermal fibroblast cells, proliferate at the wound site, helping create new tissue and extracellular matrix proteins, like collagen. The unique 'stem cell magnet' action of our allografts also recruits stem cells to the site. As a result, all phases of the wound healing process are augmented, and chronic wounds that were previously unable to be healed are closed."

The study confirmed that the MiMedx dHACM allografts positively affect at least four distinct physiological processes that are critical in wound healing.  The
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SOURCE MiMedx Group, Inc.
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