Navigation Links
Millions of DNA switches that power human genome's operating system are discovered
Date:9/5/2012

er, current technologies only allow such proteins to be studied one at a time. They also lack the accuracy to resolve the DNA letters to which the proteins dock. As a result, most of the actual DNA words recognized by regulatory proteins in living cells were unknown. To find them, the researchers employed a simple, powerful trick that enabled them to study all the proteins at once.

Instead of trying to see proteins directly, they looked for their shadows or 'footprints' on the DNA. To accomplish this, they again turned to the DNaseI enzyme that snips the DNA backbone within regulatory DNA. Prior work had shown that DNaseI likes to snip DNA next to regulatory protein docking sites, but not within the docking site itself. By using next-generation DNA sequencing technology, the researchers analyzed hundreds of millions of DNA backbone breaks made when cells were treated with DNaseI. They then used a powerful computer to resolve millions of protein footprints. In total, they identified 8.4 million such footprints along the genome, some of which were detected in many cell types. Next, they compiled all of the short DNA sequences to which the proteins were docked. They analyzed them using a software algorithm that required hundreds of microprocessors working simultaneously. This revealed that more than 90 percent of the protein docking sites were actually slight variants of 683 different DNA words -- essentially a dictionary of the genome's programming language.

"These findings significantly advance the understanding of how the instructions for controlling genes are written and organized throughout the genome, and how combinations of different instruction sets function together to control genes, often at great distance along the genome," Stamatoyannopoulos said. "The broad spectrum of cell and tissue types included in these analyses provide an incredibly rich resource that can be mined immediately by researchers around the world to illuminate
'/>"/>

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3 4

Related biology technology :

1. Center will create self-powered health monitoring devices
2. Spinach power gets a big boost
3. Waste not, power up
4. The power to heal at the tips of your fingers
5. Wireless power for the price of a penny
6. BioPower Operations Corporation Announces that FTZ Exchange Signs Strategic Alliance with Capacity 360, LLC and Tom Settineri
7. Unique properties of graphene lead to a new paradigm for low-power telecommunications
8. UCLA-led research team develops worlds most powerful nanoscale microwave oscillators
9. Syracuse University researchers use nanotechnology to harness power of fireflies
10. U of S researchers create powerful new tool for research and drug development
11. MO BIO Laboratories, Inc. Launches the PowerMicrobiomeâ„¢ RNA Isolation Kit
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Millions of DNA switches that power human genome's operating system are discovered
(Date:8/26/2015)... 26, 2015 /PRNewswire/ - iCo Therapeutics ("iCo" or "the ... results for the quarter ended June 30, 2015. ... dollars and presented under International Financial Reporting Standards ... respect to our Oral Amp B program, rapidly ... said Andrew Rae , President & CEO ...
(Date:8/26/2015)... GERMANTOWN, Md. , Aug. 26, 2015 ... synthetic biology, announced today the closing of its previously ... in full by the underwriters of their option to ... the public offering price of $41.00 per share.  The ... of shares of common stock sold by Intrexon to ...
(Date:8/26/2015)... , ... August 26, 2015 , ... PRC Clinical, ... develop new business relationships with local sponsors in southern California. The Clinical Trial Management ... drug development processes and regulatory pathways., , Stem Cell ...
(Date:8/25/2015)... Human Longevity, Inc. (HLI), the genomics-based, technology-driven company, announced today ... as Chief Operating Officer. Winham, who brings more than 25 ... report directly to HLI,s CEO, J. Craig Venter , ... Winham will be responsible for managing all HLI sequencing, laboratory ... HLI currently has three locations in San Diego ...
Breaking Biology Technology:iCo Therapeutics Announces Second Quarter 2015 Financial Results 2iCo Therapeutics Announces Second Quarter 2015 Financial Results 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 2Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 3Intrexon Announces Closing of $230 Million Public Offering of Common Stock including Full Exercise of Underwriters' Option to Purchase Additional Shares 4PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 2PRC Clinical To Attend Major Industry Conferences And Meet Sponsor Companies In The San Diego Biotech Hub 3Human Longevity, Inc. Hires Life Sciences Leader, Mark Winham, as Chief Operating Officer 2
... of African American Celebs Join Obama in Knowing their Roots in ... of African descent spawn trend in African Americans to trace roots ... ... DC (PRWEB) November 27, 2008 -- One thing President-Elect Barack Obama ...
... sailing a spacecraft by the optical force of the sun,s light. ... the oversized sails that have been tried. Now a team led ... Science has shown that the force of light indeed can ... to nano-proportions. , Their work opens the door to a ...
... must-have gift , ... New York, NY(PRWEB) November 26, 2008 --DNA 11, ... launch DNA Mini Portraits™, a more affordable line of DNA Art that ... most personal and unique gifting solution for this holiday season that are ...
Cached Biology Technology:Growing Interest in DNA-Based Genetic Testing Among African American with Historic Election of President Elect Barack Obama 2Growing Interest in DNA-Based Genetic Testing Among African American with Historic Election of President Elect Barack Obama 3'The photon force is with us': Harnessing light to drive nanomachines 2DNA 11, Creators of DNA Art, Introduces a More Affordable Line of Custom Portraits for this Year's Gift Giving Season 2
(Date:8/20/2015)... PLEASANTON, Calif. , Aug. 20, 2015 /PRNewswire/ ... focused on consumers that are active and healthy. ... used in the hospital environment to help improve ... released a video from the Wearable Technologies ... MD discussed new applications for wearables in healthcare.    ...
(Date:8/19/2015)... 19, 2015  VOXX International Corporation (Nasdaq: ... into a Definitive Agreement to purchase the assets, ... market leader EyeLock through an acquiring entity.  Upon ... controlling interest in the acquiring entity. The closing ... due diligence.  Expanding on its existing supply chain ...
(Date:8/17/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market and creator of the ... Q4 2015. The new marketing campaign is being spearheaded ... Marketing Group ( http://amplitudemarketing.com/ ) and TPMG ( http://tmpg.com/ ... in retail driven marketing and brand awareness and has ...
Breaking Biology News(10 mins):Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 2Leaf Healthcare Releases Video from Wearable Technology Conference on New Applications for Wearables in the Hospital Environment 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3
... test to detect whether a person might develop Alzheimer,s ... in their quest toward reversing the disease,s onset in ... Building on a study that started 20 years ago ... or in various stages of developing Alzheimer,s disease, the ...
... paper by a team of researchers led by Shahriar ... University of Notre Dame, provides important new insights into ... The cell wall is a critically important entity ... a rigid entity encasing the bacterium, and antibiotics are ...
... Boulder team working at 16,400 feet in the Peruvian ... glacier ice can swiftly establish a thriving community of ... plants. The discovery is the first to reveal ... of the most extreme environments on Earth and has ...
Cached Biology News:Researchers seeking to identify Alzheimer's risk focus on specific blood biomarker 2As Andean glacier retreats, tiny life forms swiftly move in, CU-Boulder study shows 2As Andean glacier retreats, tiny life forms swiftly move in, CU-Boulder study shows 3
High-throughput DNA preparation and end sequencing of BAC libraries. 3730xl DNA sequencers. LIMS tracking utilizing Geospiza's Finch system. Full-length BAC sequencing also available. Our expertise h...
... DNA sequencing is the experimental process ... DNA region. The automated DNA Sequencing is ... thermostable DNA polymerase, which allows cycle sequencing ... and detected in a capillary instrument controlled ...
... The antibody is preadsorbed to remove any reactivity ... buffered aqueous glycerol solution A solution in ... and Ca 2+ ), pH 7.3 (+/- ... protease free) and 0.05% sodium azide A synthetic ...
... The Bio-Plex maintenance, calibration, ... a custom 96-well plate used ... and calibration procedures using the ... MCV plate is for use ...
Biology Products: