Navigation Links
Millions of DNA switches that power human genome's operating system are discovered
Date:9/5/2012

The locations of millions of DNA 'switches' that dictate how, when, and where in the body different genes turn on and off have been identified by a research team led by the University of Washington in Seattle. Genes make up only 2 percent of the human genome and were easy to spot, but the on/off switches controlling those genes were encrypted within the remaining 98 percent of the genome.

Without these switches, called regulatory DNA, genes are inert. Researchers around the world have been focused on identifying regulatory DNA to understand how the genome works. Using a new technology developed with funding from the National Human Genome Research Institute's ENCODE (ENCyclopedia Of DNA Elements) project, UW researchers created the first detailed maps of where regulatory DNA is located within hundreds of different kinds of living cells. They also compiled a dictionary of the instructions written within regulatory DNA -- the genome's programming language.

The findings are reported in two papers appearing in the Sept. 5 online issue of Nature.

"These breakthrough studies provide the first extensive maps of the DNA switches that control human genes," said Dr. John A. Stamatoyannopoulos, associate professor of genome sciences and medicine at the University of Washington, and senior author on both papers. "This information is vital to understanding how the body makes different kinds of cells, and how normal gene circuitry gets rewired in disease. We are now able to read the living human genome at an unprecedented level of detail, and to begin to make sense of the complex instruction set that ultimately influences a wide range of human biology."

Here are the key results:

1) The first detailed maps of regulatory DNA switches that make up the genome's 'operating system'.

The instructions within regulatory DNA are inscribed in small DNA 'words' that function as the docking sites for special prot
'/>"/>

Contact: Leila Gray
leilag@uw.edu
206-685-0381
University of Washington
Source:Eurekalert  

Page: 1 2 3 4

Related biology technology :

1. Center will create self-powered health monitoring devices
2. Spinach power gets a big boost
3. Waste not, power up
4. The power to heal at the tips of your fingers
5. Wireless power for the price of a penny
6. BioPower Operations Corporation Announces that FTZ Exchange Signs Strategic Alliance with Capacity 360, LLC and Tom Settineri
7. Unique properties of graphene lead to a new paradigm for low-power telecommunications
8. UCLA-led research team develops worlds most powerful nanoscale microwave oscillators
9. Syracuse University researchers use nanotechnology to harness power of fireflies
10. U of S researchers create powerful new tool for research and drug development
11. MO BIO Laboratories, Inc. Launches the PowerMicrobiome™ RNA Isolation Kit
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Millions of DNA switches that power human genome's operating system are discovered
(Date:12/19/2014)... In contrast to traditional LED lights where the spectrum ... proprietary LED technology to incorporate their spectra in a ... critical in low proximity installations. The Valoya L-series offers ... which is up to four times longer than commonly ... was clearly higher when compared to traditional fluorescent or ...
(Date:12/19/2014)... San Diego, CA (PRWEB) December 18, 2014 ... announces a limited time special on Sartorius Biohit ... 1 Free on mLINE pipettes, Picus Electronic Pipette Trade-in ... recommended by Health and Safety officers around the world. ... repetitive manual pipetting. Other features include:, , ...
(Date:12/19/2014)... Egenix, Inc. is pleased to announce that Lionel Goldfrank ... succeed Donald Fresne ; Mr. Fresne has also resigned ... of the Board.  In recognition of the many contributions and ... twenty years, the Board designated Mr. Fresne as Chairman Emeritus. ... Search Committee to find a suitable replacement with Biotech industry ...
(Date:12/19/2014)... Relmada Therapeutics, Inc. (OTCQB: RLMD), a clinical-stage ... pain, announced the results of its annual general meeting ... transformational year in Relmada,s history and it set the ... Sergio Traversa , chief executive officer of Relmada. ... financial, human resource and clinical development objectives that position ...
Breaking Biology Technology:Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2
... Clear Health Communication at the National Patient Safety ... Pfizer Health Literacy in Advancing Patient Safety Award. ... the Health Literacy field were Dr. Michael Wolf, ... at Northwestern University,s Feinberg School of Medicine, and ...
... study, EPA analysis indicate vast potential for POET,s cellulosic process ... ... Corn cobs are both economical and environmentally friendly as a feedstock ... for commercializing its new technology., , , , ,Removing corn cobs ...
... Inc. ("Sinobiopharma ", or "the Company") (OTC Bulletin ... has applied for two Chinese patents for its ... relaxant. The Company has applied to China,s State ... for Atracurium,s freeze-drying compounds (Application Number 200710127756.2; "Atracurium,s ...
Cached Biology Technology:Leaders in Health Literacy Recognized by the Partnership for Clear Health Communication at the National Patient Safety Foundation 2Leaders in Health Literacy Recognized by the Partnership for Clear Health Communication at the National Patient Safety Foundation 3Research Reinforces Economic, Environmental Benefits of Corn Cobs as Source for Cellulosic Ethanol 2Research Reinforces Economic, Environmental Benefits of Corn Cobs as Source for Cellulosic Ethanol 3Sinobiopharma Applies For Two Chinese Patents For Cisatracurium Besylate 2
(Date:12/17/2014)... Va. , Dec. 15, 2014 ... to make it easier to detect and prevent ... Today the agency started performing an ... capability will validate the authenticity of purchased microcircuits ... The new quality control measures will be conducted ...
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 16, 2014 ... has licensed its PerformTek biometric technology to industry leaders ... their highly accurate, clinically validated, biometric wearable products. These ... January 6-9 in Las Vegas . ... the technology is accurate, flexible and robust – with ...
(Date:12/17/2014)...  Automation is fundamentally transforming the travel experience ... international borders. Over the past decade, ePassports, biometric ... travelers to self process through border control via ... an increasing number of airports, seaports, and land ... to Maxine Most , Principal at Acuity ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... Manchester have made a surprising finding after studying how ... for research into human healing and regeneration. It ... regenerative capacities, in contrast to mammals, including humans. For ... one will regenerate within a week. For several years ...
... scientists, working with colleagues from Aix-Marseille University, have created a ... optical system and can analyse its components within minutes. This ... different materials. The breakthrough could allow for rapid ... could detect the presence of even trace amounts of a ...
... is available in Spanish . ... Agriculture (USDA) scientists are learning more about the movement ... actively feed on crop pests. Agricultural Research ... Agricultural Research Laboratory in Brookings, S.D., and former ARS ...
Cached Biology News:The secrets of a tadpole's tail and the implications for human healing 2The secrets of a tadpole's tail and the implications for human healing 3Graphene plasmonics beats the drug cheats 2Lady beetle diet influences its effectiveness as biocontrol agent 2
... Cassettes facilitate the hybridization of DNA or ... 25mm x 75mm glass slides. The proprietary ... correct for poor flatness, as is often ... low volume chamber (67uL analytical cavity volume) ...
... This reagent is formulated specifically for Alkaline ... high levels of activity for both the ... at final dilution. This product has ... providing the customer a longer shelf life, ...
... Lambda Free Light Chain ... of human immunoglobulin. Specificity: ... epitope of lambda chain. Reacts with ... lambda chains but not with lambda ...
... The SDSaway reagent is a valuable tool ... The presence of SDS in biological ... tightly bound SDS-protein complex, inhibits enzymatic activity ... presents as a contaminant in mass spectrometry ...
Biology Products: