Navigation Links
Microsurgery on the brain of the fruit fly leads to new insights into irreparable nerve injuries
Date:6/3/2008

the fly's external skeleton, which prevents reproducible, physical manipulations of the living brain. Under the direction of VIB researcher Bassem Hassan, and in collaboration with international experts, Derya Ayaz, Maarten Leyssen and their colleagues have now developed a new technique in which the fruit fly's entire brain is cultured, enabling long-term experimentation (i.e., manipulation and observation) on the living fruit fly brain.

Fruit fly brain as model for studying damaged nerve bundles

The researchers have used this new technique explicitly to develop a fruit fly model for the regeneration of axons after injury. With the aid of micro-dissection, the researchers inflicted injuries on the nerve fibers and then studied them for several days. As is the case for humans, the regeneration of damaged nerve bundles in fruit fly brains is as good as non-existent.

In a next step, the researchers are using this new model to study which molecular processes might be able to promote this regeneration. They have already demonstrated that activation of the JNK signaling pathway positively influences the repair of nerve bundles. JNK activation not only stimulates the growth of the severed nerves but the nerves also grow correctly in the direction of their original target region in the brain.

Perspectives for the future

In the future, this new model can be used to identify new molecules that are involved in the repair of damaged nerve bundles. These molecules will then be candidate molecules for further research with humans, and they can possibly form the basis of new treatments for patients with a nerve injury that has been irreparable up to now.


'/>"/>

Contact: Evy Vierstraete
info@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

Page: 1 2

Related biology technology :

1. ONCOSCIENCE AG, THE EUROPEAN PARTNER OF YM BIOSCIENCES, ANNOUNCES COMPLETION OF PATIENT ENROLLMENT IN PHASE III BRAIN CANCER TRIAL OF NIMOTUZUMAB
2. YM BioSciences USA cleared by US FDA to initiate Phase II clinical trial of nimotuzumab in children with inoperable, recurrent brain cancer
3. NIH grants $750,000 to develop device to determine temperature of neonates brain
4. InSightec Resumes Clinical Trials for Non-Invasive Treatment of Brain Tumors
5. Scientists create colorful brainbow images of the nervous system
6. Mouse Brain or Impressionist Painting?
7. GlaxoSmithKline Announces Data on TYKERB(R) (Lapatinib) Plus Capecitabine for the Treatment of HER2 Positive Breast Cancer Brain Metastases
8. Henry Ford Hospital and Rosetta Genomics to Develop MicroRNA-based Diagnostics for Brain Cancer
9. Elekta Chosen to Deliver Sophisticated Brain Mapping Technology to The Nebraska Medical Center
10. BrainCells Inc. Completes $30 Million Initial Closing of Series B Financing
11. Elekta Chosen to Deliver Sophisticated Brain Mapping Technology to Froedtert Hospital in Milwaukee
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... zFlo Motion , a US leader in biomechanics ... from a new partner. STT-Systems has developed an ... years, with offerings in the optical-motion capture, 3D scanning, and ... measurement unit), iSen, is opening eyes around the world. With ...
(Date:1/22/2015)... 2015 Selexis SA, a serial innovation ... Banks (RCBs) used for drug discovery to commercial manufacturing, ... include Next-Generation Sequencing (NGS) data packages. The ... manufacturing by ensuring the integrity of the gene, validation ...
(Date:1/22/2015)... DIEGO , Jan. 22, 2015   Cypher ... and Sequenom, Inc. (NASDAQ: SQNM ), ... development agreement for next generation noninvasive prenatal tests ... genome interpretation technology, called Mantis™, to advance analysis ...
(Date:1/22/2015)... , Jan. 22, 2015  Derma Sciences, Inc. ... company focused on advanced wound care, announces that ... tissues, have been added to the Premier, Inc. ... the opportunity for the AMNIOEXCEL® and AMNIOMATRIX® product ...
Breaking Biology Technology:3D Motion Capture Just Got Easy 2Selexis Generated Research Cell Banks Now Fully Sequenced Using Next-Generation Sequencing 2Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5
... Introduction , ... algorithms for monitoring GeneChip ® expression data. These ... designed to accommodate the typical distribution of data found ... statistical techniques and are optimized to accommodate advancements in ...
... Chromatography and Mass Spectrometry Application Report , ... serum Acepromazine , Gargi Choudhary, Thermo ... Wayne Skinner and Scott Stanley, University of California, Davis ... Acepromazine is widely used as a sedative in horses. ...
... Mass Spectrometry Application Note , Kevin ... Thermo Electron Corporation, Somerset, NJ, USA , ... Acrylamide has been identified as a potential ... industrial chemical, but acrylamide was recently discovered to be present at significant ...
Cached Biology Technology:New statistical algorithms for Monitoring Gene Expression on GeneChip® Probe Arrays 2New statistical algorithms for Monitoring Gene Expression on GeneChip® Probe Arrays 3New statistical algorithms for Monitoring Gene Expression on GeneChip® Probe Arrays 4New statistical algorithms for Monitoring Gene Expression on GeneChip® Probe Arrays 5New statistical algorithms for Monitoring Gene Expression on GeneChip® Probe Arrays 6Determination of Acepromazine and its Major Metabolite in Equine Serum by LC-MS/MS using the Finnigan LCQ Deca XP Plus Ion Trap Mass Spectrometer 2Determination of Acepromazine and its Major Metabolite in Equine Serum by LC-MS/MS using the Finnigan LCQ Deca XP Plus Ion Trap Mass Spectrometer 3Determination of Acepromazine and its Major Metabolite in Equine Serum by LC-MS/MS using the Finnigan LCQ Deca XP Plus Ion Trap Mass Spectrometer 4Quantitation of Acrylamide in Food Samples on the Finnigan TSQ Quantum Discovery by LC/APCI-MS/MS 2Quantitation of Acrylamide in Food Samples on the Finnigan TSQ Quantum Discovery by LC/APCI-MS/MS 3Quantitation of Acrylamide in Food Samples on the Finnigan TSQ Quantum Discovery by LC/APCI-MS/MS 4Quantitation of Acrylamide in Food Samples on the Finnigan TSQ Quantum Discovery by LC/APCI-MS/MS 5Quantitation of Acrylamide in Food Samples on the Finnigan TSQ Quantum Discovery by LC/APCI-MS/MS 6
(Date:1/22/2015)... Inc. , a market leader of iris-based identity authentication solutions, ... the new role of Senior Vice President of Mobile and ... platforms and wearable solutions for EyeLock,s technologies. Gerber brings more ... industry to his role at EyeLock, with expertise in human ...
(Date:12/24/2014)... YORK , Dec. 23, 2014  Since its launch in December ... people to eliminate the pain of trying to remember their ... own biometrics fused to their smartphones. To assist people who ... , the company that created 1U and focuses on redefining ...
(Date:12/22/2014)... 22, 2014 Research and Markets ( ... "The Global Watermarking and Fingerprinting Markets" ... http://photos.prnewswire.com/prnh/20130307/600769 This insight provides ... and fingerprinting markets. Watermarking aims to control and ...
Breaking Biology News(10 mins):EyeLock Names Steve Gerber as Senior Vice President of Mobile and Wearables 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3The Global Watermarking and Fingerprinting Markets 2
... American Society for Microbiology (ASM) sanofi-aventis U.S. Award ... WWAMI Regional Center of Excellence for Biodefense and ... an unrestricted grant from sanofi-aventis U.S., this award ... his professional life, Dr. Stamm has worked with ...
... of biosolids (treated municipal sewage sludge) is a common ... nutrients and organic matter. However, the presence of detectable ... farmland application may result in accumulation of dioxins in ... chain because several congeners of dioxins have extremely high ...
... Spanish . Cancer is a disease characterised ... give higher proliferative capacity to cancer cells, but they ... research group led by Dr. Jos Carlos Fernndez-Checa in ... (IIBB-CSIC), a centre linked to the Institut d,Investigacions Biomdiques ...
Cached Biology News:Dioxin risk in soil and plant tissues after long-term biosolids application 2Mitochondrial cholesterol makes response to chemotherapy difficult in hepatic cancer 2
Donor Horse Serum US Origin...
jub, ajuba homolog (Xenopus laevis)...
Size & Applications: 100 ul (2 mM). Recommend to use at 1000X dilutions for cell culture (e.g. Add 1 ul to 1 ml of culture medium.) Storage Temp.: -20C Shelf Life: 6-12 month...
NM522 contains an F episome, which is required for production of ssDNA and for blue/white color selection. To maintain the F, NM522 should be grown on minimal (M-9) medium....
Biology Products: