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Microsurgery on the brain of the fruit fly leads to new insights into irreparable nerve injuries
Date:6/3/2008

Leuven, Belgium − Every year, one million Europeans are confronted with potentially irreparable brain or spinal cord injuries resulting from traffic accidents. Because the nerves in a damaged spinal cord cannot, or cannot fully, be repaired, the patient remains (partially) paralyzed. Now, VIB scientists connected to the K.U.Leuven have become the first to successfully develop a simple model that enables the study of injured brain tissue. The researchers have perfected a technique for keeping the cultured brain of a fruit fly alive and healthy for a longer period of time. With the aid of microsurgery, this new technique enables scientists to inflict injury on certain nerve bundles for research purposes. By means of this new fruit fly model, the researchers have already succeeded in showing that the activation of a particular signaling pathway (JNK) induces the regeneration of axons. This research offers positive perspectives for patients with nerve injuries that have been irreversible up to now.

Drosophila as model organism

The Drosophila melanogaster fruit fly is an important, low-cost model organism with a 60% genetic similarity to humans. The fruit fly is playing a significant role in the elucidation of various neurological processes (such as the functioning of our memory and our sense of smell) as well as in the study of certain neurodegenerative diseases (such as Alzheimer's disease). Until recently, scientists could only use model organisms belonging to the vertebrates (e.g., the mouse) to study injuries to the nervous system and the possibility of regenerating damaged axons. However, the fruit fly model is more user-friendly and allows faster, large-scale genetic analyses.

The fruit fly brain in culture

Although the fruit fly model is used for numerous diseases, until now it has not been possible to study the repair of damaged axons with fruit flies. Indeed, the fruit fly's brain is difficult to access due to
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Contact: Evy Vierstraete
info@vib.be
329-244-6611
VIB (the Flanders Institute for Biotechnology)
Source:Eurekalert

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