Navigation Links
Microscopic 'clutch' puts flagellum in neutral
Date:6/19/2008

BLOOMINGTON, Ind. -- A tiny but powerful engine that propels the bacterium Bacillus subtilis through liquids is disengaged from the corkscrew-like flagellum by a protein clutch, Indiana University Bloomington and Harvard University scientists have learned. Their report appears in this week's Science.

Scientists have long known what drives the flagellum to spin, but what causes the flagellum to stop spinning -- temporarily or permanently -- was unknown.

"We think it's pretty cool that evolving bacteria and human engineers arrived at a similar solution to the same problem," said IU Bloomington biologist Daniel Kearns, who led the project. "How do you temporarily stop a motor once it gets going?"

The action of the protein they discovered, EpsE, is very similar to that of a car clutch. In cars, the clutch controls whether a car's engine is connected to the parts that spin its wheels. With the engine and gears disengaged from each other, the car may continue to move, but only because of its prior momentum; the wheels are no longer powered.

EpsE is thought to "sit down," as Kearns describes it, on the flagellum's rotor, a donut-shaped structure at the base of the flagellum. EpsE's interaction with a rotor protein called FliG causes a shape change in the rotor that disengages it from the flagellum's proton-powered engine.

The discovery of EpsE and its function was accidental. Kearns and colleagues were actually interested in learning more about the genes that cause individual cells of B. subtilis to cease wandering in solitude and take up residence in a massively communal, stationary assemblage called a biofilm. The stability of biofilms can be jeopardized by hyperactive bacterial cells whose flagella continue to spin.

"We were trying to get at how the bacterium's ability to move and biofilm formation are balanced," Kearns said. "We were looking for the genes that affected whether the cell
'/>"/>

Contact: David Bricker
brickerd@indiana.edu
812-856-9035
Indiana University
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Explosives at the microscopic scale produce shocking results
2. Arryx Launches HOTkit(TM) Complete for Dynamic, Scientific Manipulation of Microscopic Elements
3. BioNeutral Announces a BREAKTHROUGH in the Fight Against Bioterrorism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Microscopic 'clutch' puts flagellum in neutral
(Date:3/5/2015)... Southlake, Texas (PRWEB) March 05, 2015 ... treatment of acute and chronic orthopedic conditions such ... runner’s knee, tennis elbow, and joint pain due ... also be administered during orthopedic surgeries to promote ... patented scientific advances in nearly pain-free bone marrow ...
(Date:3/4/2015)... , March 4, 2015 The UPMC ... its 2015 Fellows in the Emerging Leaders in Biosecurity ... future leaders in the field of biosecurity, UPMC has ... from a wide array of backgrounds, including biological science, ... sector. "With the vision and support ...
(Date:3/4/2015)... 04, 2015 Research and Markets ... Jain PharmaBiotech,s new report "Biomarkers - Technologies, ... This report follows the broad definition ... be objectively measured and evaluated as an indicator ... as pharmacological responses to a therapeutic intervention. Tests ...
(Date:3/4/2015)... PRC Clinical, a full-service, ... Bay Area, will exhibit and present at the ... on March 25th and 26th in Tel Aviv, Israel. ... Israeli life science companies seeking to conduct U.S. Food ... span all phases of human trials, from Phase I ...
Breaking Biology Technology:Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 2Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 3Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 4Riordan-McKenna Institute of Regenerative Orthopedics and Stem Cell Therapy Announces Open House in Southlake, Texas on Friday, March 6th from 5:30 pm to 7:30 pm. 5UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 2UPMC Center for Health Security Announces 2015 Emerging Leaders in Biosecurity 3Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 2Global Biomarkers Report 2014-2024 - Technologies, Markets and Companies 3PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 2PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 3PRC Clinical to Present at Inaugural Outsourcing in Clinical Trials Israel Conference 2015 on March 25 and 26th in Tel Aviv 4
...  Bunker Hill Community College (BHCC) celebrated the graduation ... Program (CBCP) in a ceremony that also marked ... a collaborative effort between BHCC,s Workforce Development Center, ... It targets low-income Cambridge residents who complete – ...
... 2012 Rhythm announced today the results of a ... ghrelin agonist for the treatment of diabetic gastroparesis. The ... patients with diabetic gastroparesis. The findings were presented at ... The Phase 1b clinical trial was a ...
... 22, 2012   IntelliCell BioSciences, Inc. ("Company") (OTCQB: SVFC.PK)  announced ... agreement with the Institute for Cell Engineering and ... A portion of the collaborative work will be ... autologous vascular cells that are also referred to ...
Cached Biology Technology:Bunker Hill Community College Holds Biomedical Careers Graduation Ceremony 2Rhythm Announces Phase 1b Results for Ghrelin Prokinetic RM-131 for Diabetic Gastroparesis 2IntelliCell BioSciences Announces Collaborative Agreement with the University of Florida on Stem Cell and Tissue Repair Research 2IntelliCell BioSciences Announces Collaborative Agreement with the University of Florida on Stem Cell and Tissue Repair Research 3
(Date:2/19/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kx9zp8/military ) ... Electro-Optical / Infrared Systems Market by Type, by ... to 2020" report to their offering. ... expected to reach $16.35 billion by 2020, to ... report segments the military electro-optical/infrared systems market on ...
(Date:2/13/2015)... ACT Genomics Co., Ltd., a cancer ... cancer genomic information into precision diagnosis and personalized ... US$ 8 million in the its first private funding ... Taiwan , ACT Genomics has developed comprehensive ... to implement next generation sequencing (NGS) and multiplex ...
(Date:2/12/2015)... 12, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile commerce ... 62/113114 for DISTRIBUTED METHOD AND SYSTEM TO ... patent further establishes NXT-ID,s position in the emerging "Internet ... the ability for multiple devices to collaborate with one ...
Breaking Biology News(10 mins):Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3ACT Genomics Raises $8 Million in its First Private Funding Round 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 2NXT-ID Patents Collaborative Services to Enable the "Internet of Things" 3
... The Antarctic ozone hole, which yawns wide every Southern ... It stretched to 10.05 million square miles, the ninth ... the ozone hole reached its deepest point of the ... 10th lowest in this 26-year record. NASA and ...
... data sets for a group of birds and employing ... the evolutionary family tree for one of the most ... the Hawaiian honeycreepers. Not only have the ... family originally evolved from, but they have also linked ...
... 20, 2011) -- Junrong Zheng,s techniques to see the fine ... University scientist a highly prestigious Packard Fellowship. Zheng ... use the five-year grant that comes with the fellowship to ... -- the shape and orientation -- of any molecule, no ...
Cached Biology News:NASA, NOAA data show significant Antarctic ozone hole remains 2NASA, NOAA data show significant Antarctic ozone hole remains 3Scientists determine family tree for most-endangered bird family in the world 2Scientists determine family tree for most-endangered bird family in the world 3Rice's Zheng wins Packard Fellowship 2
... SearchLight® IR Mouse Cytokine Array is a ... the quantitative measurement of 12 cytokines in ... culture supernatants. Each well of the microplate ... specific cytokines in standards and samples added ...
... DNA transformation can be difficult to achieve ... presence of one or more restriction and ... that is recognized as "foreign". TypeOne™ Restriction ... transformation efficiencies in bacterial strains with type ...
... AMPure is a magnetic bead-based ... no sample transfer, centrifugation or ... small and large PCR extension ... microplates. Agencourt AMPure can easily ...
... This kit is designed for the ... large vector plasmids at any position (for ... included loxP-PGK-gb2-neo-loxP cassette is designed to allow ... eukaryotic cells. It combines a prokaryotic promoter ...
Biology Products: